{"publication_status":"published","doi":"10.1021/acs.jpclett.8b00176","article_type":"letter_note","main_file_link":[{"url":"https://europepmc.org/article/med/29376375#free-full-text","open_access":"1"}],"scopus_import":"1","intvolume":"         9","quality_controlled":"1","title":"Probing charge transport through peptide bonds","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1948-7185"]},"publisher":"American Chemical Society","volume":9,"article_processing_charge":"No","oa_version":"Submitted Version","issue":"4","OA_type":"green","author":[{"first_name":"Joseph M.","last_name":"Brisendine","full_name":"Brisendine, Joseph M."},{"last_name":"Refaely-Abramson","first_name":"Sivan","full_name":"Refaely-Abramson, Sivan"},{"full_name":"Liu, Zhen-Fei","first_name":"Zhen-Fei","last_name":"Liu"},{"full_name":"Cui, Jing","last_name":"Cui","first_name":"Jing"},{"last_name":"Ng","first_name":"Fay","full_name":"Ng, Fay"},{"full_name":"Neaton, Jeffrey B.","first_name":"Jeffrey B.","last_name":"Neaton"},{"full_name":"Koder, Ronald L.","first_name":"Ronald L.","last_name":"Koder"},{"full_name":"Venkataraman, Latha","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","orcid":"0000-0002-6957-6089","first_name":"Latha","last_name":"Venkataraman"}],"month":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","type":"journal_article","date_created":"2024-09-09T08:34:32Z","external_id":{"pmid":["29376375"]},"OA_place":"repository","day":"27","page":"763-767","pmid":1,"abstract":[{"text":"We measure the conductance of unmodified peptides at the single-molecule level using the scanning tunneling microscope-based break-junction method, utilizing the N-terminal amine group and the C-terminal carboxyl group as gold metal-binding linkers. Our conductance measurements of oligoglycine and oligoalanine backbones do not rely on peptide side-chain linkers. We compare our results with alkanes terminated asymmetrically with an amine group on one end and a carboxyl group on the other to show that peptide bonds decrease the conductance of an otherwise saturated carbon chain. Using a newly developed first-principles approach, we attribute the decrease in conductance to charge localization at the peptide bond, which reduces the energy of the frontier orbitals relative to the Fermi energy and the electronic coupling to the leads, lowering the tunneling probability. Crucially, this manifests as an increase in conductance decay of peptide backbones with increasing length when compared with alkanes.","lang":"eng"}],"citation":{"ista":"Brisendine JM, Refaely-Abramson S, Liu Z-F, Cui J, Ng F, Neaton JB, Koder RL, Venkataraman L. 2018. Probing charge transport through peptide bonds. The Journal of Physical Chemistry Letters. 9(4), 763–767.","apa":"Brisendine, J. M., Refaely-Abramson, S., Liu, Z.-F., Cui, J., Ng, F., Neaton, J. B., … Venkataraman, L. (2018). Probing charge transport through peptide bonds. <i>The Journal of Physical Chemistry Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.jpclett.8b00176\">https://doi.org/10.1021/acs.jpclett.8b00176</a>","ieee":"J. M. Brisendine <i>et al.</i>, “Probing charge transport through peptide bonds,” <i>The Journal of Physical Chemistry Letters</i>, vol. 9, no. 4. American Chemical Society, pp. 763–767, 2018.","mla":"Brisendine, Joseph M., et al. “Probing Charge Transport through Peptide Bonds.” <i>The Journal of Physical Chemistry Letters</i>, vol. 9, no. 4, American Chemical Society, 2018, pp. 763–67, doi:<a href=\"https://doi.org/10.1021/acs.jpclett.8b00176\">10.1021/acs.jpclett.8b00176</a>.","ama":"Brisendine JM, Refaely-Abramson S, Liu Z-F, et al. Probing charge transport through peptide bonds. <i>The Journal of Physical Chemistry Letters</i>. 2018;9(4):763-767. doi:<a href=\"https://doi.org/10.1021/acs.jpclett.8b00176\">10.1021/acs.jpclett.8b00176</a>","chicago":"Brisendine, Joseph M., Sivan Refaely-Abramson, Zhen-Fei Liu, Jing Cui, Fay Ng, Jeffrey B. Neaton, Ronald L. Koder, and Latha Venkataraman. “Probing Charge Transport through Peptide Bonds.” <i>The Journal of Physical Chemistry Letters</i>. American Chemical Society, 2018. <a href=\"https://doi.org/10.1021/acs.jpclett.8b00176\">https://doi.org/10.1021/acs.jpclett.8b00176</a>.","short":"J.M. Brisendine, S. Refaely-Abramson, Z.-F. Liu, J. Cui, F. Ng, J.B. Neaton, R.L. Koder, L. Venkataraman, The Journal of Physical Chemistry Letters 9 (2018) 763–767."},"_id":"17934","date_published":"2018-01-27T00:00:00Z","publication":"The Journal of Physical Chemistry Letters","date_updated":"2024-12-17T09:41:02Z","year":"2018","extern":"1","oa":1}