---
_id: '1801'
abstract:
- lang: eng
text: Brain circuits are assembled from a large variety of morphologically and functionally
diverse cell types. It is not known how the intermingled cell types of an individual
adult brain region differ in their expressed genomes. Here we describe an atlas
of cell type transcriptomes in one brain region, the mouse retina. We found that
each adult cell type expressed a specific set of genes, including a unique set
of transcription factors, forming a 'barcode' for cell identity. Cell type transcriptomes
carried enough information to categorize cells into morphological classes and
types. Several genes that were specifically expressed in particular retinal circuit
elements, such as inhibitory neuron types, are associated with eye diseases. The
resource described here allows gene expression to be compared across adult retinal
cell types, experimenting with specific transcription factors to differentiate
stem or somatic cells to retinal cell types, and predicting cellular targets of
newly discovered disease-associated genes.
acknowledgement: The study was supported by Friedrich Miescher Institute funds, Alcon
award, a National Center of Competence in Research Genetics grant, a European Research
Council grant, a Swiss-Hungarian grant, and RETICIRC, TREATRUSH, SEEBETTER and OPTONEURO
grants from the European Union to B.R.
author:
- first_name: Sandra
full_name: Sandra Siegert
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
- first_name: Erik
full_name: Cabuy, Erik
last_name: Cabuy
- first_name: Brigitte
full_name: Scherf, Brigitte G
last_name: Scherf
- first_name: Hubertus
full_name: Kohler, Hubertus
last_name: Kohler
- first_name: Satchidananda
full_name: Panda, Satchidananda
last_name: Panda
- first_name: Yunzheng
full_name: Le, Yunzheng
last_name: Le
- first_name: Hans
full_name: Fehling, Hans J
last_name: Fehling
- first_name: Dimos
full_name: Gaidatzis, Dimos
last_name: Gaidatzis
- first_name: Michael
full_name: Stadler, Michael B
last_name: Stadler
- first_name: Botond
full_name: Roska, Botond M
last_name: Roska
citation:
ama: Siegert S, Cabuy E, Scherf B, et al. Transcriptional code and disease map for
adult retinal cell types. Nature Neuroscience. 2012;15(3):487-495. doi:10.1038/nn.3032
apa: Siegert, S., Cabuy, E., Scherf, B., Kohler, H., Panda, S., Le, Y., … Roska,
B. (2012). Transcriptional code and disease map for adult retinal cell types.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3032
chicago: Siegert, Sandra, Erik Cabuy, Brigitte Scherf, Hubertus Kohler, Satchidananda
Panda, Yunzheng Le, Hans Fehling, Dimos Gaidatzis, Michael Stadler, and Botond
Roska. “Transcriptional Code and Disease Map for Adult Retinal Cell Types.” Nature
Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3032.
ieee: S. Siegert et al., “Transcriptional code and disease map for adult
retinal cell types,” Nature Neuroscience, vol. 15, no. 3. Nature Publishing
Group, pp. 487–495, 2012.
ista: Siegert S, Cabuy E, Scherf B, Kohler H, Panda S, Le Y, Fehling H, Gaidatzis
D, Stadler M, Roska B. 2012. Transcriptional code and disease map for adult retinal
cell types. Nature Neuroscience. 15(3), 487–495.
mla: Siegert, Sandra, et al. “Transcriptional Code and Disease Map for Adult Retinal
Cell Types.” Nature Neuroscience, vol. 15, no. 3, Nature Publishing Group,
2012, pp. 487–95, doi:10.1038/nn.3032.
short: S. Siegert, E. Cabuy, B. Scherf, H. Kohler, S. Panda, Y. Le, H. Fehling,
D. Gaidatzis, M. Stadler, B. Roska, Nature Neuroscience 15 (2012) 487–495.
date_created: 2018-12-11T11:54:05Z
date_published: 2012-03-01T00:00:00Z
date_updated: 2021-01-12T06:53:17Z
day: '01'
doi: 10.1038/nn.3032
extern: 1
intvolume: ' 15'
issue: '3'
month: '03'
page: 487 - 495
publication: Nature Neuroscience
publication_status: published
publisher: Nature Publishing Group
publist_id: '5309'
quality_controlled: 0
status: public
title: Transcriptional code and disease map for adult retinal cell types
type: journal_article
volume: 15
year: '2012'
...