Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution

article Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution published yes Mark Tobias Bollenbach author 3E6DB97A-F248-11E8-B48F-1D18A9856A870000-0003-4398-476X ToBo department Revealing the mechanisms underlying drug interactions project Optimality principles in responses to antibiotics project Revealing the fundamental limits of cell growth project Combining antibiotics is a promising strategy for increasing treatment efficacy and for controlling resistance evolution. When drugs are combined, their effects on cells may be amplified or weakened, that is the drugs may show synergistic or antagonistic interactions. Recent work revealed the underlying mechanisms of such drug interactions by elucidating the drugs'; joint effects on cell physiology. Moreover, new treatment strategies that use drug combinations to exploit evolutionary tradeoffs were shown to affect the rate of resistance evolution in predictable ways. High throughput studies have further identified drug candidates based on their interactions with established antibiotics and general principles that enable the prediction of drug interactions were suggested. Overall, the conceptual and technical foundation for the rational design of potent drug combinations is rapidly developing. https://research-explorer.ista.ac.at/download/1810/5277/IST-2016-493-v1+1_1-s2.0-S1369527415000594-main.pdf application/pdfno https://creativecommons.org/licenses/by/4.0/ Elsevier2015 eng Current Opinion in Microbiology 00036506540000310.1016/j.mib.2015.05.008 271 - 9 Bollenbach, M. T. (2015). Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution. Current Opinion in Microbiology. Elsevier. <a href="https://doi.org/10.1016/j.mib.2015.05.008">https://doi.org/10.1016/j.mib.2015.05.008</a> Bollenbach, Mark Tobias. “Antimicrobial Interactions: Mechanisms and Implications for Drug Discovery and Resistance Evolution.” Current Opinion in Microbiology, vol. 27, Elsevier, 2015, pp. 1–9, doi:<a href="https://doi.org/10.1016/j.mib.2015.05.008">10.1016/j.mib.2015.05.008</a>. Bollenbach MT. 2015. Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution. Current Opinion in Microbiology. 27, 1–9. M.T. Bollenbach, Current Opinion in Microbiology 27 (2015) 1–9. M. T. Bollenbach, “Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution,” Current Opinion in Microbiology, vol. 27. Elsevier, pp. 1–9, 2015. Bollenbach, Mark Tobias. “Antimicrobial Interactions: Mechanisms and Implications for Drug Discovery and Resistance Evolution.” Current Opinion in Microbiology. Elsevier, 2015. <a href="https://doi.org/10.1016/j.mib.2015.05.008">https://doi.org/10.1016/j.mib.2015.05.008</a>. Bollenbach MT. Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution. Current Opinion in Microbiology. 2015;27:1-9. doi:<a href="https://doi.org/10.1016/j.mib.2015.05.008">10.1016/j.mib.2015.05.008</a> 18102018-12-11T11:54:08Z2025-09-23T07:55:38Z