---
_id: '1810'
abstract:
- lang: eng
  text: Combining antibiotics is a promising strategy for increasing treatment efficacy
    and for controlling resistance evolution. When drugs are combined, their effects
    on cells may be amplified or weakened, that is the drugs may show synergistic
    or antagonistic interactions. Recent work revealed the underlying mechanisms of
    such drug interactions by elucidating the drugs'; joint effects on cell physiology.
    Moreover, new treatment strategies that use drug combinations to exploit evolutionary
    tradeoffs were shown to affect the rate of resistance evolution in predictable
    ways. High throughput studies have further identified drug candidates based on
    their interactions with established antibiotics and general principles that enable
    the prediction of drug interactions were suggested. Overall, the conceptual and
    technical foundation for the rational design of potent drug combinations is rapidly
    developing.
article_processing_charge: No
author:
- first_name: Mark Tobias
  full_name: Bollenbach, Mark Tobias
  id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
  last_name: Bollenbach
  orcid: 0000-0003-4398-476X
citation:
  ama: 'Bollenbach MT. Antimicrobial interactions: Mechanisms and implications for
    drug discovery and resistance evolution. <i>Current Opinion in Microbiology</i>.
    2015;27:1-9. doi:<a href="https://doi.org/10.1016/j.mib.2015.05.008">10.1016/j.mib.2015.05.008</a>'
  apa: 'Bollenbach, M. T. (2015). Antimicrobial interactions: Mechanisms and implications
    for drug discovery and resistance evolution. <i>Current Opinion in Microbiology</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.mib.2015.05.008">https://doi.org/10.1016/j.mib.2015.05.008</a>'
  chicago: 'Bollenbach, Mark Tobias. “Antimicrobial Interactions: Mechanisms and Implications
    for Drug Discovery and Resistance Evolution.” <i>Current Opinion in Microbiology</i>.
    Elsevier, 2015. <a href="https://doi.org/10.1016/j.mib.2015.05.008">https://doi.org/10.1016/j.mib.2015.05.008</a>.'
  ieee: 'M. T. Bollenbach, “Antimicrobial interactions: Mechanisms and implications
    for drug discovery and resistance evolution,” <i>Current Opinion in Microbiology</i>,
    vol. 27. Elsevier, pp. 1–9, 2015.'
  ista: 'Bollenbach MT. 2015. Antimicrobial interactions: Mechanisms and implications
    for drug discovery and resistance evolution. Current Opinion in Microbiology.
    27, 1–9.'
  mla: 'Bollenbach, Mark Tobias. “Antimicrobial Interactions: Mechanisms and Implications
    for Drug Discovery and Resistance Evolution.” <i>Current Opinion in Microbiology</i>,
    vol. 27, Elsevier, 2015, pp. 1–9, doi:<a href="https://doi.org/10.1016/j.mib.2015.05.008">10.1016/j.mib.2015.05.008</a>.'
  short: M.T. Bollenbach, Current Opinion in Microbiology 27 (2015) 1–9.
corr_author: '1'
date_created: 2018-12-11T11:54:08Z
date_published: 2015-06-01T00:00:00Z
date_updated: 2025-09-23T07:55:38Z
day: '01'
ddc:
- '570'
department:
- _id: ToBo
doi: 10.1016/j.mib.2015.05.008
ec_funded: 1
external_id:
  isi:
  - '000365065400003'
file:
- access_level: open_access
  checksum: 1683bb0f42ef892a5b3b71a050d65d25
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:17:23Z
  date_updated: 2020-07-14T12:45:17Z
  file_id: '5277'
  file_name: IST-2016-493-v1+1_1-s2.0-S1369527415000594-main.pdf
  file_size: 1047255
  relation: main_file
file_date_updated: 2020-07-14T12:45:17Z
fulldoi: https://doi.org/10.1016/j.mib.2015.05.008
has_accepted_license: '1'
intvolume: '        27'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1 - 9
project:
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P27201-B22
  name: Revealing the mechanisms underlying drug interactions
- _id: 25E83C2C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '303507'
  name: Optimality principles in responses to antibiotics
- _id: 25EB3A80-B435-11E9-9278-68D0E5697425
  grant_number: RGP0042/2013
  name: Revealing the fundamental limits of cell growth
publication: Current Opinion in Microbiology
publication_status: published
publisher: Elsevier
publist_id: '5298'
pubrep_id: '493'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Antimicrobial interactions: Mechanisms and implications for drug discovery
  and resistance evolution'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 27
year: '2015'
...