{"citation":{"short":"A. Basu, A. Singh, S. Sehgal, T. Madaan, N.G. Prasad, Journal of Invertebrate Pathology 207 (2024).","chicago":"Basu, Aabeer, Aparajita Singh, Suhaas Sehgal, Tanvi Madaan, and Nagaraj Guru Prasad. “Starvation Increases Susceptibility to Bacterial Infection and Promotes Systemic Pathogen Proliferation in Drosophila Melanogaster Females.” <i>Journal of Invertebrate Pathology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.jip.2024.108209\">https://doi.org/10.1016/j.jip.2024.108209</a>.","ama":"Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females. <i>Journal of Invertebrate Pathology</i>. 2024;207. doi:<a href=\"https://doi.org/10.1016/j.jip.2024.108209\">10.1016/j.jip.2024.108209</a>","ista":"Basu A, Singh A, Sehgal S, Madaan T, Prasad NG. 2024. Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females. Journal of Invertebrate Pathology. 207, 108209.","ieee":"A. Basu, A. Singh, S. Sehgal, T. Madaan, and N. G. Prasad, “Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females,” <i>Journal of Invertebrate Pathology</i>, vol. 207. Elsevier, 2024.","mla":"Basu, Aabeer, et al. “Starvation Increases Susceptibility to Bacterial Infection and Promotes Systemic Pathogen Proliferation in Drosophila Melanogaster Females.” <i>Journal of Invertebrate Pathology</i>, vol. 207, 108209, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.jip.2024.108209\">10.1016/j.jip.2024.108209</a>.","apa":"Basu, A., Singh, A., Sehgal, S., Madaan, T., &#38; Prasad, N. G. (2024). Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females. <i>Journal of Invertebrate Pathology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jip.2024.108209\">https://doi.org/10.1016/j.jip.2024.108209</a>"},"publication_status":"published","article_type":"original","doi":"10.1016/j.jip.2024.108209","scopus_import":"1","status":"public","oa_version":"None","external_id":{"pmid":["39322010"]},"type":"journal_article","article_number":"108209","intvolume":"       207","language":[{"iso":"eng"}],"acknowledgement":"The authors thank Tejashwini Hegde for logistical support during execution of the experiments reported here. The authors thank Prof. P. Cornelis (Vrije Universiteit Brussel, Belgium) for providing the Pseudomonas entomophila isolate, Dr. Elio Sucena and Tania Paulo (Instituto Gulbenkian Ciencia, Portugal) for providing the Erwinia c. carotovora, and Prof. Brian Lazzaro (Cornell University, USA) for providing the Enterococcus faecalis and Providencia rettgeri isolates, and Dr. Karan Singh (IISER Mohali, India) for isolating the Staphylococcus succinus isolate used in the experiments. The authors also thank Dr. Manas Geeta Arun for maintenance of the LH fly populations used in this study.\r\nThe study was funded by intra-mural funding from IISER Mohali, India, to NGP. AB was supported by Senior Research Fellowship for PhD students from CSIR, Govt. of India. AS was supported by Senior Research Fellowship for PhD students from UGC, Govt. of India. SS and TM were supported by KVPY fellowships for undergraduate studies from DST, Govt. of India.","quality_controlled":"1","abstract":[{"text":"Defense against pathogens and parasites requires substantial investment of energy and resources on part of the host. This makes the host immune function dependent on availability and accessibility of resources. A resource deprived host is therefore expected to be more susceptible to infections, although empirical results do not always align with this prediction. Limiting host access to resources can additionally impact within-host pathogen numbers, either directly by altering the amount of resources available to the pathogens for proliferation or indirectly by altering the efficiency of the host immune system. We tested for the effects of host starvation (complete deprivation of resources) on susceptibility to bacterial pathogens, and within-host pathogen proliferation, in Drosophila melanogaster females. Our results show that starvation increases post-infection mortality of the host, but in a pathogen-specific manner. This increase in mortality is always accompanied by increased within-host pathogen proliferation. We therefore propose that starvation compromises host resistance to bacterial infections in Drosophila melanogaster females thereby increasing susceptibility to infections.","lang":"eng"}],"title":"Starvation increases susceptibility to bacterial infection and promotes systemic pathogen proliferation in Drosophila melanogaster females","corr_author":"1","pmid":1,"article_processing_charge":"No","date_published":"2024-09-27T00:00:00Z","year":"2024","publication_identifier":{"eissn":["1096-0805"],"issn":["0022-2011"]},"author":[{"full_name":"Basu, Aabeer","first_name":"Aabeer","last_name":"Basu"},{"last_name":"Singh","first_name":"Aparajita","full_name":"Singh, Aparajita"},{"full_name":"Sehgal, Suhaas","first_name":"Suhaas","last_name":"Sehgal"},{"last_name":"Madaan","id":"419917ac-5355-11ee-ae5a-c952babcaad9","full_name":"Madaan, Tanvi","first_name":"Tanvi"},{"full_name":"Prasad, Nagaraj Guru","first_name":"Nagaraj Guru","last_name":"Prasad"}],"date_updated":"2024-10-07T10:25:22Z","department":[{"_id":"SyCr"}],"day":"27","month":"09","publication":"Journal of Invertebrate Pathology","publisher":"Elsevier","date_created":"2024-10-06T22:01:11Z","_id":"18171","volume":207,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"}