---
res:
  bibo_abstract:
  - Vaccination is the most effective tool to control infectious diseases. However,
    the evolution of vaccine resistance, exemplified by vaccine resistance in SARS-CoV-2,
    remains a concern. Here, we model complex vaccination strategies against a pathogen
    with multiple epitopes—molecules targeted by the vaccine. We found that a vaccine
    targeting one epitope was ineffective in preventing vaccine escape. Vaccine resistance
    in highly infectious pathogens was prevented by the full-epitope vaccine, that
    is, one targeting all available epitopes, but only when the rate of pathogen evolution
    was low. Strikingly, a bet-hedging strategy of random administration of vaccines
    targeting different epitopes was the most effective in preventing vaccine resistance
    in pathogens with the low rate of infection and high rate of evolution. Thus,
    complex vaccination strategies, when biologically feasible, may be preferable
    to the currently used single-vaccine approaches for long-term control of disease
    outbreaks, especially when applied to livestock with near 100% vaccination rates.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Rella, Simon
      foaf_surname: Rella
      foaf_workInfoHomepage: http://www.librecat.org/personId=B4765ACA-AA38-11E9-AC9A-0930E6697425
  - foaf_Person:
      foaf_givenName: Yuliya A.
      foaf_name: Kulikova, Yuliya A.
      foaf_surname: Kulikova
  - foaf_Person:
      foaf_givenName: Aygul
      foaf_name: Minnegalieva, Aygul
      foaf_surname: Minnegalieva
      foaf_workInfoHomepage: http://www.librecat.org/personId=87DF77F0-1D9A-11EA-B6AE-CE443DDC885E
  - foaf_Person:
      foaf_givenName: Fyodor
      foaf_name: Kondrashov, Fyodor
      foaf_surname: Kondrashov
      foaf_workInfoHomepage: http://www.librecat.org/personId=44FDEF62-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8243-4694
  bibo_doi: 10.1093/evolut/qpae106
  bibo_issue: '10'
  bibo_volume: 78
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001286581900001
  dct_isPartOf:
  - http://id.crossref.org/issn/1558-5646
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: Complex vaccination strategies prevent the emergence of vaccine resistance@
  fabio_hasPubmedId: '38990788'
...