{"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"publication_status":"published","ddc":["570"],"doi":"10.1093/evolut/qpae106","OA_place":"publisher","article_type":"original","month":"10","related_material":{"record":[{"id":"14862","relation":"research_data","status":"public"}],"link":[{"url":"https://github.com/Simon-Re/complex-vaccination","relation":"software"}]},"issue":"10","page":"1722-1738","author":[{"id":"B4765ACA-AA38-11E9-AC9A-0930E6697425","first_name":"Simon","full_name":"Rella, Simon","last_name":"Rella"},{"full_name":"Kulikova, Yuliya A.","first_name":"Yuliya A.","last_name":"Kulikova"},{"last_name":"Minnegalieva","id":"87DF77F0-1D9A-11EA-B6AE-CE443DDC885E","first_name":"Aygul","full_name":"Minnegalieva, Aygul"},{"full_name":"Kondrashov, Fyodor","first_name":"Fyodor","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8243-4694","last_name":"Kondrashov"}],"volume":78,"publication_identifier":{"eissn":["1558-5646"]},"date_published":"2024-10-01T00:00:00Z","publisher":"Oxford Academic","title":"Complex vaccination strategies prevent the emergence of vaccine resistance","corr_author":"1","file_date_updated":"2024-10-21T09:34:50Z","day":"01","publication":"Evolution: International journal of organic evolution","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2024","department":[{"_id":"GaTk"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","citation":{"mla":"Rella, Simon, et al. “Complex Vaccination Strategies Prevent the Emergence of Vaccine Resistance.” <i>Evolution: International Journal of Organic Evolution</i>, vol. 78, no. 10, Oxford Academic, 2024, pp. 1722–38, doi:<a href=\"https://doi.org/10.1093/evolut/qpae106\">10.1093/evolut/qpae106</a>.","ieee":"S. Rella, Y. A. Kulikova, A. Minnegalieva, and F. Kondrashov, “Complex vaccination strategies prevent the emergence of vaccine resistance,” <i>Evolution: International journal of organic evolution</i>, vol. 78, no. 10. Oxford Academic, pp. 1722–1738, 2024.","ista":"Rella S, Kulikova YA, Minnegalieva A, Kondrashov F. 2024. Complex vaccination strategies prevent the emergence of vaccine resistance. Evolution: International journal of organic evolution. 78(10), 1722–1738.","short":"S. Rella, Y.A. Kulikova, A. Minnegalieva, F. Kondrashov, Evolution: International Journal of Organic Evolution 78 (2024) 1722–1738.","apa":"Rella, S., Kulikova, Y. A., Minnegalieva, A., &#38; Kondrashov, F. (2024). Complex vaccination strategies prevent the emergence of vaccine resistance. <i>Evolution: International Journal of Organic Evolution</i>. Oxford Academic. <a href=\"https://doi.org/10.1093/evolut/qpae106\">https://doi.org/10.1093/evolut/qpae106</a>","ama":"Rella S, Kulikova YA, Minnegalieva A, Kondrashov F. Complex vaccination strategies prevent the emergence of vaccine resistance. <i>Evolution: International journal of organic evolution</i>. 2024;78(10):1722-1738. doi:<a href=\"https://doi.org/10.1093/evolut/qpae106\">10.1093/evolut/qpae106</a>","chicago":"Rella, Simon, Yuliya A. Kulikova, Aygul Minnegalieva, and Fyodor Kondrashov. “Complex Vaccination Strategies Prevent the Emergence of Vaccine Resistance.” <i>Evolution: International Journal of Organic Evolution</i>. Oxford Academic, 2024. <a href=\"https://doi.org/10.1093/evolut/qpae106\">https://doi.org/10.1093/evolut/qpae106</a>."},"scopus_import":"1","oa":1,"language":[{"iso":"eng"}],"_id":"18307","date_updated":"2024-10-21T09:38:05Z","status":"public","intvolume":"        78","file":[{"content_type":"application/pdf","date_created":"2024-10-21T09:34:50Z","file_size":29360811,"file_name":"2024_Evolution_Rella.pdf","creator":"dernst","relation":"main_file","access_level":"open_access","file_id":"18453","success":1,"checksum":"5c6e8475bb88b07d424a5130d5e91e74","date_updated":"2024-10-21T09:34:50Z"}],"date_created":"2024-10-13T22:01:50Z","article_processing_charge":"Yes (via OA deal)","abstract":[{"text":"Vaccination is the most effective tool to control infectious diseases. However, the evolution of vaccine resistance, exemplified by vaccine resistance in SARS-CoV-2, remains a concern. Here, we model complex vaccination strategies against a pathogen with multiple epitopes—molecules targeted by the vaccine. We found that a vaccine targeting one epitope was ineffective in preventing vaccine escape. Vaccine resistance in highly infectious pathogens was prevented by the full-epitope vaccine, that is, one targeting all available epitopes, but only when the rate of pathogen evolution was low. Strikingly, a bet-hedging strategy of random administration of vaccines targeting different epitopes was the most effective in preventing vaccine resistance in pathogens with the low rate of infection and high rate of evolution. Thus, complex vaccination strategies, when biologically feasible, may be preferable to the currently used single-vaccine approaches for long-term control of disease outbreaks, especially when applied to livestock with near 100% vaccination rates.","lang":"eng"}],"quality_controlled":"1","OA_type":"hybrid","oa_version":"Published Version","type":"journal_article","acknowledgement":"We thank Raimundo Julian Saona Urmeneta, Maike Morrison, Sergey Kryazhimskiy, Hiroki Ishikawa, Simone Pigolotti, and Shingo Miyauchi for fruitful discussions. We also thank the participants of the FRISBI seminar at ISTA for useful comments."}