---
OA_place: publisher
OA_type: hybrid
_id: '18307'
abstract:
- lang: eng
  text: Vaccination is the most effective tool to control infectious diseases. However,
    the evolution of vaccine resistance, exemplified by vaccine resistance in SARS-CoV-2,
    remains a concern. Here, we model complex vaccination strategies against a pathogen
    with multiple epitopes—molecules targeted by the vaccine. We found that a vaccine
    targeting one epitope was ineffective in preventing vaccine escape. Vaccine resistance
    in highly infectious pathogens was prevented by the full-epitope vaccine, that
    is, one targeting all available epitopes, but only when the rate of pathogen evolution
    was low. Strikingly, a bet-hedging strategy of random administration of vaccines
    targeting different epitopes was the most effective in preventing vaccine resistance
    in pathogens with the low rate of infection and high rate of evolution. Thus,
    complex vaccination strategies, when biologically feasible, may be preferable
    to the currently used single-vaccine approaches for long-term control of disease
    outbreaks, especially when applied to livestock with near 100% vaccination rates.
acknowledgement: We thank Raimundo Julian Saona Urmeneta, Maike Morrison, Sergey Kryazhimskiy,
  Hiroki Ishikawa, Simone Pigolotti, and Shingo Miyauchi for fruitful discussions.
  We also thank the participants of the FRISBI seminar at ISTA for useful comments.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Simon
  full_name: Rella, Simon
  id: B4765ACA-AA38-11E9-AC9A-0930E6697425
  last_name: Rella
- first_name: Yuliya A.
  full_name: Kulikova, Yuliya A.
  last_name: Kulikova
- first_name: Aygul
  full_name: Minnegalieva, Aygul
  id: 87DF77F0-1D9A-11EA-B6AE-CE443DDC885E
  last_name: Minnegalieva
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: 'Rella S, Kulikova YA, Minnegalieva A, Kondrashov F. Complex vaccination strategies
    prevent the emergence of vaccine resistance. <i>Evolution: International journal
    of organic evolution</i>. 2024;78(10):1722-1738. doi:<a href="https://doi.org/10.1093/evolut/qpae106">10.1093/evolut/qpae106</a>'
  apa: 'Rella, S., Kulikova, Y. A., Minnegalieva, A., &#38; Kondrashov, F. (2024).
    Complex vaccination strategies prevent the emergence of vaccine resistance. <i>Evolution:
    International Journal of Organic Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/evolut/qpae106">https://doi.org/10.1093/evolut/qpae106</a>'
  chicago: 'Rella, Simon, Yuliya A. Kulikova, Aygul Minnegalieva, and Fyodor Kondrashov.
    “Complex Vaccination Strategies Prevent the Emergence of Vaccine Resistance.”
    <i>Evolution: International Journal of Organic Evolution</i>. Oxford University
    Press, 2024. <a href="https://doi.org/10.1093/evolut/qpae106">https://doi.org/10.1093/evolut/qpae106</a>.'
  ieee: 'S. Rella, Y. A. Kulikova, A. Minnegalieva, and F. Kondrashov, “Complex vaccination
    strategies prevent the emergence of vaccine resistance,” <i>Evolution: International
    journal of organic evolution</i>, vol. 78, no. 10. Oxford University Press, pp.
    1722–1738, 2024.'
  ista: 'Rella S, Kulikova YA, Minnegalieva A, Kondrashov F. 2024. Complex vaccination
    strategies prevent the emergence of vaccine resistance. Evolution: International
    journal of organic evolution. 78(10), 1722–1738.'
  mla: 'Rella, Simon, et al. “Complex Vaccination Strategies Prevent the Emergence
    of Vaccine Resistance.” <i>Evolution: International Journal of Organic Evolution</i>,
    vol. 78, no. 10, Oxford University Press, 2024, pp. 1722–38, doi:<a href="https://doi.org/10.1093/evolut/qpae106">10.1093/evolut/qpae106</a>.'
  short: 'S. Rella, Y.A. Kulikova, A. Minnegalieva, F. Kondrashov, Evolution: International
    Journal of Organic Evolution 78 (2024) 1722–1738.'
corr_author: '1'
date_created: 2024-10-13T22:01:50Z
date_published: 2024-10-01T00:00:00Z
date_updated: 2026-04-07T12:34:57Z
day: '01'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.1093/evolut/qpae106
external_id:
  isi:
  - '001286581900001'
  pmid:
  - '38990788'
file:
- access_level: open_access
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  creator: dernst
  date_created: 2024-10-21T09:34:50Z
  date_updated: 2024-10-21T09:34:50Z
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  file_name: 2024_Evolution_Rella.pdf
  file_size: 29360811
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file_date_updated: 2024-10-21T09:34:50Z
has_accepted_license: '1'
intvolume: '        78'
isi: 1
issue: '10'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '10'
oa: 1
oa_version: Published Version
page: 1722-1738
pmid: 1
publication: 'Evolution: International journal of organic evolution'
publication_identifier:
  eissn:
  - 1558-5646
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/Simon-Re/complex-vaccination
  record:
  - id: '14862'
    relation: research_data
    status: public
  - id: '20811'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Complex vaccination strategies prevent the emergence of vaccine resistance
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 78
year: '2024'
...