---
res:
  bibo_abstract:
  - Huge body of evidences demonstrated that volatile anesthetics affect the hippocampal
    neurogenesis and neurocognitive functions, and most of them showed impairment
    at anesthetic dose. Here, we investigated the effect of low dose (1.8%) sevoflurane
    on hippocampal neurogenesis and dentate gyrus-dependent learning. Neonatal rats
    at postnatal day 4 to 6 (P4-6) were treated with 1.8% sevoflurane for 6 hours.
    Neurogenesis was quantified by bromodeoxyuridine labeling and electrophysiology
    recording. Four and seven weeks after treatment, the Morris water maze and contextual-fear
    discrimination learning tests were performed to determine the influence on spatial
    learning and pattern separation. A 6-hour treatment with 1.8% sevoflurane promoted
    hippocampal neurogenesis and increased the survival of newborn cells and the proportion
    of immature granular cells in the dentate gyrus of neonatal rats. Sevoflurane-treated
    rats performed better during the training days of the Morris water maze test and
    in contextual-fear discrimination learning test. These results suggest that a
    subanesthetic dose of sevoflurane promotes hippocampal neurogenesis in neonatal
    rats and facilitates their performance in dentate gyrus-dependent learning tasks.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Chong
      foaf_name: Chen, Chong
      foaf_surname: Chen
      foaf_workInfoHomepage: http://www.librecat.org/personId=3DFD581A-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Chao
      foaf_name: Wang, Chao
      foaf_surname: Wang
  - foaf_Person:
      foaf_givenName: Xuan
      foaf_name: Zhao, Xuan
      foaf_surname: Zhao
  - foaf_Person:
      foaf_givenName: Tao
      foaf_name: Zhou, Tao
      foaf_surname: Zhou
  - foaf_Person:
      foaf_givenName: Dao
      foaf_name: Xu, Dao
      foaf_surname: Xu
  - foaf_Person:
      foaf_givenName: Zhi
      foaf_name: Wang, Zhi
      foaf_surname: Wang
  - foaf_Person:
      foaf_givenName: Ying
      foaf_name: Wang, Ying
      foaf_surname: Wang
  bibo_doi: 10.1177/1759091415575845
  bibo_issue: '2'
  bibo_volume: 7
  dct_date: 2015^xs_gYear
  dct_identifier:
  - UT:000353223200002
  dct_language: eng
  dct_publisher: SAGE Publications@
  dct_title: Low-dose sevoflurane promoteshippocampal neurogenesis and facilitates
    the development of dentate gyrus-dependent learning in neonatal rats@
...