---
res:
  bibo_abstract:
  - How living systems achieve precision in form and function despite their intrinsic
    stochasticity is a fundamental yet ongoing question in biology. We generated morphomaps
    of preimplantation embryogenesis in mouse, rabbit, and monkey embryos, and these
    morphomaps revealed that although blastomere divisions desynchronized passively,
    8-cell embryos converged toward robust three-dimensional shapes. Using topological
    analysis and genetic perturbations, we found that embryos progressively changed
    their cellular connectivity to a preferred topology, which could be predicted
    by a physical model in which actomyosin contractility and noise facilitate topological
    transitions, lowering surface energy. This mechanism favored regular embryo packing
    and promoted a higher number of inner cells in the 16-cell embryo. Synchronized
    division reduced embryo packing and generated substantially more misallocated
    cells and fewer inner-cell–mass cells. These findings suggest that stochasticity
    in division timing contributes to robust patterning.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Dimitri
      foaf_name: Fabrèges, Dimitri
      foaf_surname: Fabrèges
  - foaf_Person:
      foaf_givenName: Bernat
      foaf_name: Corominas-Murtra, Bernat
      foaf_surname: Corominas-Murtra
      foaf_workInfoHomepage: http://www.librecat.org/personId=43BE2298-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9806-5643
  - foaf_Person:
      foaf_givenName: Prachiti
      foaf_name: Moghe, Prachiti
      foaf_surname: Moghe
  - foaf_Person:
      foaf_givenName: Alison
      foaf_name: Kickuth, Alison
      foaf_surname: Kickuth
  - foaf_Person:
      foaf_givenName: Takafumi
      foaf_name: Ichikawa, Takafumi
      foaf_surname: Ichikawa
  - foaf_Person:
      foaf_givenName: Chizuru
      foaf_name: Iwatani, Chizuru
      foaf_surname: Iwatani
  - foaf_Person:
      foaf_givenName: Tomoyuki
      foaf_name: Tsukiyama, Tomoyuki
      foaf_surname: Tsukiyama
  - foaf_Person:
      foaf_givenName: Nathalie
      foaf_name: Daniel, Nathalie
      foaf_surname: Daniel
  - foaf_Person:
      foaf_givenName: Julie
      foaf_name: Gering, Julie
      foaf_surname: Gering
  - foaf_Person:
      foaf_givenName: Anniek
      foaf_name: Stokkermans, Anniek
      foaf_surname: Stokkermans
  - foaf_Person:
      foaf_givenName: Adrian
      foaf_name: Wolny, Adrian
      foaf_surname: Wolny
  - foaf_Person:
      foaf_givenName: Anna
      foaf_name: Kreshuk, Anna
      foaf_surname: Kreshuk
  - foaf_Person:
      foaf_givenName: Véronique
      foaf_name: Duranthon, Véronique
      foaf_surname: Duranthon
  - foaf_Person:
      foaf_givenName: Virginie
      foaf_name: Uhlman, Virginie
      foaf_surname: Uhlman
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Takashi
      foaf_name: Hiiragi, Takashi
      foaf_surname: Hiiragi
  bibo_doi: 10.1126/science.adh1145
  bibo_issue: '6718'
  bibo_volume: 386
  dct_date: 2024^xs_gYear
  dct_identifier:
  - UT:001422132300018
  dct_isPartOf:
  - http://id.crossref.org/issn/1095-9203
  dct_language: eng
  dct_publisher: AAAS@
  dct_title: Temporal variability and cell mechanics control robustness in mammalian
    embryogenesis@
  fabio_hasPubmedId: '39388574'
...