---
res:
  bibo_abstract:
  - The ability to escape apoptosis is a hallmark of cancer-initiating cells and a
    key factor of resistance to oncolytic therapy. Here, we identify FAM96A as a ubiquitous,
    evolutionarily conserved apoptosome-activating protein and investigate its potential
    pro-apoptotic tumor suppressor function in gastrointestinal stromal tumors (GISTs).
    Interaction between FAM96A and apoptotic peptidase activating factor 1 (APAF1)
    was identified in yeast two-hybrid screen and further studied by deletion mutants,
    glutathione-S-transferase pull-down, co-immunoprecipitation and immunofluorescence.
    Effects of FAM96A overexpression and knock-down on apoptosis sensitivity were
    examined in cancer cells and zebrafish embryos. Expression of FAM96A in GISTs
    and histogenetically related cells including interstitial cells of Cajal (ICCs),
    “fibroblast-like cells” (FLCs) and ICC stem cells (ICC-SCs) was investigated by
    Northern blotting, reverse transcription—polymerase chain reaction, immunohistochemistry
    and Western immunoblotting. Tumorigenicity of GIST cells and transformed murine
    ICC-SCs stably transduced to re-express FAM96A was studied by xeno- and allografting
    into immunocompromised mice. FAM96A was found to bind APAF1 and to enhance the
    induction of mitochondrial apoptosis. FAM96A protein or mRNA was dramatically
    reduced or lost in 106 of 108 GIST samples representing three independent patient
    cohorts. Whereas ICCs, ICC-SCs and FLCs, the presumed normal counterparts of GIST,
    were found to robustly express FAM96A protein and mRNA, FAM96A expression was
    much reduced in tumorigenic ICC-SCs. Re-expression of FAM96A in GIST cells and
    transformed ICC-SCs increased apoptosis sensitivity and diminished tumorigenicity.
    Our data suggest FAM96A is a novel pro-apoptotic tumor suppressor that is lost
    during GIST tumorigenesis.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Bettina
      foaf_name: Schwamb, Bettina
      foaf_surname: Schwamb
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Pick, Robert
      foaf_surname: Pick
  - foaf_Person:
      foaf_givenName: Sara
      foaf_name: Fernández, Sara
      foaf_surname: Fernández
  - foaf_Person:
      foaf_givenName: Kirsten
      foaf_name: Völp, Kirsten
      foaf_surname: Völp
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Heering, Jan
      foaf_surname: Heering
  - foaf_Person:
      foaf_givenName: Volker
      foaf_name: Dötsch, Volker
      foaf_surname: Dötsch
  - foaf_Person:
      foaf_givenName: Susanne
      foaf_name: Bösser, Susanne
      foaf_surname: Bösser
  - foaf_Person:
      foaf_givenName: Jennifer
      foaf_name: Jung, Jennifer
      foaf_surname: Jung
  - foaf_Person:
      foaf_givenName: Rasa
      foaf_name: Beinoravičiute Kellner, Rasa
      foaf_surname: Beinoravičiute Kellner
  - foaf_Person:
      foaf_givenName: Josephine
      foaf_name: Wesely, Josephine
      foaf_surname: Wesely
  - foaf_Person:
      foaf_givenName: Inka
      foaf_name: Zörnig, Inka
      foaf_surname: Zörnig
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Hammerschmidt, Matthias
      foaf_surname: Hammerschmidt
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Nowak, Matthias
      foaf_surname: Nowak
      foaf_workInfoHomepage: http://www.librecat.org/personId=30845DAA-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Roland
      foaf_name: Penzel, Roland
      foaf_surname: Penzel
  - foaf_Person:
      foaf_givenName: Kurt
      foaf_name: Zatloukal, Kurt
      foaf_surname: Zatloukal
  - foaf_Person:
      foaf_givenName: Stefan
      foaf_name: Joos, Stefan
      foaf_surname: Joos
  - foaf_Person:
      foaf_givenName: Ralf
      foaf_name: Rieker, Ralf
      foaf_surname: Rieker
  - foaf_Person:
      foaf_givenName: Abbas
      foaf_name: Agaimy, Abbas
      foaf_surname: Agaimy
  - foaf_Person:
      foaf_givenName: Stephan
      foaf_name: Söder, Stephan
      foaf_surname: Söder
  - foaf_Person:
      foaf_givenName: Kmarie
      foaf_name: Reid Lombardo, Kmarie
      foaf_surname: Reid Lombardo
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Kendrick, Michael
      foaf_surname: Kendrick
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Bardsley, Michael
      foaf_surname: Bardsley
  - foaf_Person:
      foaf_givenName: Yujiro
      foaf_name: Hayashi, Yujiro
      foaf_surname: Hayashi
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Asuzu, David
      foaf_surname: Asuzu
  - foaf_Person:
      foaf_givenName: Sabriya
      foaf_name: Syed, Sabriya
      foaf_surname: Syed
  - foaf_Person:
      foaf_givenName: Tamás
      foaf_name: Ördög, Tamás
      foaf_surname: Ördög
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Zörnig, Martin
      foaf_surname: Zörnig
  bibo_doi: 10.1002/ijc.29498
  bibo_issue: '6'
  bibo_volume: 137
  dct_date: 2015^xs_gYear
  dct_identifier:
  - UT:000357808900012
  dct_language: eng
  dct_publisher: Wiley@
  dct_title: FAM96A is a novel pro-apoptotic tumor suppressor in gastrointestinal
    stromal tumors@
  fabio_hasPubmedId: '25716227'
...