---
_id: '1852'
abstract:
- lang: eng
  text: To control morphogenesis, molecular regulatory networks have to interfere
    with the mechanical properties of the individual cells of developing organs and
    tissues, but how this is achieved is not well known. We study this issue here
    in the shoot meristem of higher plants, a group of undifferentiated cells where
    complex changes in growth rates and directions lead to the continuous formation
    of new organs [1, 2]. Here, we show that the plant hormone auxin plays an important
    role in this process via a dual, local effect on the extracellular matrix, the
    cell wall, which determines cell shape. Our study reveals that auxin not only
    causes a limited reduction in wall stiffness but also directly interferes with
    wall anisotropy via the regulation of cortical microtubule dynamics. We further
    show that to induce growth isotropy and organ outgrowth, auxin somehow interferes
    with the cortical microtubule-ordering activity of a network of proteins, including
    AUXIN BINDING PROTEIN 1 and KATANIN 1. Numerical simulations further indicate
    that the induced isotropy is sufficient to amplify the effects of the relatively
    minor changes in wall stiffness to promote organogenesis and the establishment
    of new growth axes in a robust manner.
acknowledgement: 'This work was funded by grants from EraSysBio+ (iSAM) and ERC (Morphodynamics). '
article_processing_charge: No
author:
- first_name: Massimiliano
  full_name: Sassi, Massimiliano
  last_name: Sassi
- first_name: Olivier
  full_name: Ali, Olivier
  last_name: Ali
- first_name: Frédéric
  full_name: Boudon, Frédéric
  last_name: Boudon
- first_name: Gladys
  full_name: Cloarec, Gladys
  last_name: Cloarec
- first_name: Ursula
  full_name: Abad, Ursula
  last_name: Abad
- first_name: Coralie
  full_name: Cellier, Coralie
  last_name: Cellier
- first_name: Xu
  full_name: Chen, Xu
  id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Benjamin
  full_name: Gilles, Benjamin
  last_name: Gilles
- first_name: Pascale
  full_name: Milani, Pascale
  last_name: Milani
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Teva
  full_name: Vernoux, Teva
  last_name: Vernoux
- first_name: Christophe
  full_name: Godin, Christophe
  last_name: Godin
- first_name: Olivier
  full_name: Hamant, Olivier
  last_name: Hamant
- first_name: Jan
  full_name: Traas, Jan
  last_name: Traas
citation:
  ama: Sassi M, Ali O, Boudon F, et al. An auxin-mediated shift toward growth isotropy
    promotes organ formation at the shoot meristem in Arabidopsis. <i>Current Biology</i>.
    2014;24(19):2335-2342. doi:<a href="https://doi.org/10.1016/j.cub.2014.08.036">10.1016/j.cub.2014.08.036</a>
  apa: Sassi, M., Ali, O., Boudon, F., Cloarec, G., Abad, U., Cellier, C., … Traas,
    J. (2014). An auxin-mediated shift toward growth isotropy promotes organ formation
    at the shoot meristem in Arabidopsis. <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.cub.2014.08.036">https://doi.org/10.1016/j.cub.2014.08.036</a>
  chicago: Sassi, Massimiliano, Olivier Ali, Frédéric Boudon, Gladys Cloarec, Ursula
    Abad, Coralie Cellier, Xu Chen, et al. “An Auxin-Mediated Shift toward Growth
    Isotropy Promotes Organ Formation at the Shoot Meristem in Arabidopsis.” <i>Current
    Biology</i>. Cell Press, 2014. <a href="https://doi.org/10.1016/j.cub.2014.08.036">https://doi.org/10.1016/j.cub.2014.08.036</a>.
  ieee: M. Sassi <i>et al.</i>, “An auxin-mediated shift toward growth isotropy promotes
    organ formation at the shoot meristem in Arabidopsis,” <i>Current Biology</i>,
    vol. 24, no. 19. Cell Press, pp. 2335–2342, 2014.
  ista: Sassi M, Ali O, Boudon F, Cloarec G, Abad U, Cellier C, Chen X, Gilles B,
    Milani P, Friml J, Vernoux T, Godin C, Hamant O, Traas J. 2014. An auxin-mediated
    shift toward growth isotropy promotes organ formation at the shoot meristem in
    Arabidopsis. Current Biology. 24(19), 2335–2342.
  mla: Sassi, Massimiliano, et al. “An Auxin-Mediated Shift toward Growth Isotropy
    Promotes Organ Formation at the Shoot Meristem in Arabidopsis.” <i>Current Biology</i>,
    vol. 24, no. 19, Cell Press, 2014, pp. 2335–42, doi:<a href="https://doi.org/10.1016/j.cub.2014.08.036">10.1016/j.cub.2014.08.036</a>.
  short: M. Sassi, O. Ali, F. Boudon, G. Cloarec, U. Abad, C. Cellier, X. Chen, B.
    Gilles, P. Milani, J. Friml, T. Vernoux, C. Godin, O. Hamant, J. Traas, Current
    Biology 24 (2014) 2335–2342.
date_created: 2018-12-11T11:54:22Z
date_published: 2014-10-06T00:00:00Z
date_updated: 2025-09-29T13:10:45Z
day: '06'
department:
- _id: JiFr
doi: 10.1016/j.cub.2014.08.036
external_id:
  isi:
  - '000342747600031'
intvolume: '        24'
isi: 1
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://hal.archives-ouvertes.fr/hal-01074821
month: '10'
oa: 1
oa_version: Submitted Version
page: 2335 - 2342
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '5248'
quality_controlled: '1'
scopus_import: '1'
status: public
title: An auxin-mediated shift toward growth isotropy promotes organ formation at
  the shoot meristem in Arabidopsis
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 24
year: '2014'
...