---
_id: '1862'
abstract:
- lang: eng
  text: The prominent and evolutionarily ancient role of the plant hormone auxin is
    the regulation of cell expansion. Cell expansion requires ordered arrangement
    of the cytoskeleton but molecular mechanisms underlying its regulation by signalling
    molecules including auxin are unknown. Here we show in the model plant Arabidopsis
    thaliana that in elongating cells exogenous application of auxin or redistribution
    of endogenous auxin induces very rapid microtubule re-orientation from transverse
    to longitudinal, coherent with the inhibition of cell expansion. This fast auxin
    effect requires auxin binding protein 1 (ABP1) and involves a contribution of
    downstream signalling components such as ROP6 GTPase, ROP-interactive protein
    RIC1 and the microtubule-severing protein katanin. These components are required
    for rapid auxin-and ABP1-mediated re-orientation of microtubules to regulate cell
    elongation in roots and dark-grown hypocotyls as well as asymmetric growth during
    gravitropic responses.
acknowledgement: We thank R. Dixit for performing complementary experiments, D. W.
  Ehrhardt and T. Hashimoto for providing the seeds of TUB6–RFP and EB1b–GFP respectively,
  E. Zazimalova, J. Petrasek and M. Fendrych for discussing the manuscript and J.
  Leung for text optimization. This work was supported by the European Research Council
  (project ERC-2011-StG-20101109-PSDP, to J.F.), ANR blanc AuxiWall project (ANR-11-BSV5-0007,
  to C.P.-R. and L.G.) and the Agency for Innovation by Science and Technology (IWT)
  (to H.R.). This work benefited from the facilities and expertise of the Imagif Cell
  Biology platform (http://www.imagif.cnrs.fr), which is supported by the Conseil
  Général de l’Essonne.
article_processing_charge: No
article_type: original
author:
- first_name: Xu
  full_name: Chen, Xu
  id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Laurie
  full_name: Grandont, Laurie
  last_name: Grandont
- first_name: Hongjiang
  full_name: Li, Hongjiang
  id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
  last_name: Li
  orcid: 0000-0001-5039-9660
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Sébastien
  full_name: Paque, Sébastien
  last_name: Paque
- first_name: Anas
  full_name: Abuzeineh, Anas
  last_name: Abuzeineh
- first_name: Hana
  full_name: Rakusova, Hana
  id: 4CAAA450-78D2-11EA-8E57-B40A396E08BA
  last_name: Rakusova
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Catherine
  full_name: Perrot Rechenmann, Catherine
  last_name: Perrot Rechenmann
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Chen X, Grandont L, Li H, et al. Inhibition of cell expansion by rapid ABP1-mediated
    auxin effect on microtubules. <i>Nature</i>. 2014;516(729):90-93. doi:<a href="https://doi.org/10.1038/nature13889">10.1038/nature13889</a>
  apa: Chen, X., Grandont, L., Li, H., Hauschild, R., Paque, S., Abuzeineh, A., …
    Friml, J. (2014). Inhibition of cell expansion by rapid ABP1-mediated auxin effect
    on microtubules. <i>Nature</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/nature13889">https://doi.org/10.1038/nature13889</a>
  chicago: Chen, Xu, Laurie Grandont, Hongjiang Li, Robert Hauschild, Sébastien Paque,
    Anas Abuzeineh, Hana Rakusova, Eva Benková, Catherine Perrot Rechenmann, and Jiří
    Friml. “Inhibition of Cell Expansion by Rapid ABP1-Mediated Auxin Effect on Microtubules.”
    <i>Nature</i>. Nature Publishing Group, 2014. <a href="https://doi.org/10.1038/nature13889">https://doi.org/10.1038/nature13889</a>.
  ieee: X. Chen <i>et al.</i>, “Inhibition of cell expansion by rapid ABP1-mediated
    auxin effect on microtubules,” <i>Nature</i>, vol. 516, no. 729. Nature Publishing
    Group, pp. 90–93, 2014.
  ista: Chen X, Grandont L, Li H, Hauschild R, Paque S, Abuzeineh A, Rakusova H, Benková
    E, Perrot Rechenmann C, Friml J. 2014. Inhibition of cell expansion by rapid ABP1-mediated
    auxin effect on microtubules. Nature. 516(729), 90–93.
  mla: Chen, Xu, et al. “Inhibition of Cell Expansion by Rapid ABP1-Mediated Auxin
    Effect on Microtubules.” <i>Nature</i>, vol. 516, no. 729, Nature Publishing Group,
    2014, pp. 90–93, doi:<a href="https://doi.org/10.1038/nature13889">10.1038/nature13889</a>.
  short: X. Chen, L. Grandont, H. Li, R. Hauschild, S. Paque, A. Abuzeineh, H. Rakusova,
    E. Benková, C. Perrot Rechenmann, J. Friml, Nature 516 (2014) 90–93.
corr_author: '1'
date_created: 2018-12-11T11:54:25Z
date_published: 2014-12-04T00:00:00Z
date_updated: 2025-09-29T13:10:05Z
day: '04'
department:
- _id: JiFr
- _id: Bio
- _id: EvBe
doi: 10.1038/nature13889
ec_funded: 1
external_id:
  isi:
  - '000346310800045'
  pmid:
  - '25409144'
fulldoi: https://doi.org/10.1038/nature13889
intvolume: '       516'
isi: 1
issue: '729'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4257754/
month: '12'
oa: 1
oa_version: Submitted Version
page: 90 - 93
pmid: 1
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '282300'
  name: Polarity and subcellular dynamics in plants
publication: Nature
publication_identifier:
  eissn:
  - 1476-4687
  issn:
  - 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '5237'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inhibition of cell expansion by rapid ABP1-mediated auxin effect on microtubules
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 516
year: '2014'
...