---
res:
  bibo_abstract:
  - The human brain has remarkable computational power. It generates sophisticated
    behavioral sequences, stores engrams over an individual’s lifetime, and produces
    higher cognitive functions up to the level of consciousness. However, so little
    of our neuroscience knowledge covers the human brain, and it remains unknown whether
    this organ is truly unique, or is a scaled version of the extensively studied
    rodent brain. To address this fundamental question, we determined the cellular,
    synaptic, and connectivity rules of the hippocampal CA3 recurrent circuit using
    multicellular patch clamp-recording. This circuit is the largest autoassociative
    network in the brain, and plays a key role in memory and higher-order computations
    such as pattern separation and pattern completion. We demonstrate that human hippocampal
    CA3 employs sparse connectivity, in stark contrast to neocortical recurrent networks.
    Connectivity sparsifies from rodents to humans, providing a circuit architecture
    that maximizes associational power. Unitary synaptic events at human CA3–CA3 synapses
    showed both distinct species-specific and circuit-dependent properties, with high
    reliability, unique amplitude precision, and long integration times. We also identify
    differential scaling rules between hippocampal pathways from rodents to humans,
    with a moderate increase in the convergence of CA3 inputs per cell, but a marked
    increase in human mossy fiber innervation. Anatomically guided full-scale modeling
    suggests that the human brain’s sparse connectivity, expanded neuronal number,
    and reliable synaptic signaling combine to enhance the associative memory storage
    capacity of CA3. Together, our results reveal unique rules of connectivity and
    synaptic signaling in the human hippocampus, demonstrating the absolute necessity
    of human brain research and beginning to unravel the remarkable performance of
    our autoassociative memory circuits.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jake F.
      foaf_name: Watson, Jake F.
      foaf_surname: Watson
  - foaf_Person:
      foaf_givenName: Victor
      foaf_name: Vargas-Barroso, Victor
      foaf_surname: Vargas-Barroso
  - foaf_Person:
      foaf_givenName: Rebecca J.
      foaf_name: Morse-Mora, Rebecca J.
      foaf_surname: Morse-Mora
  - foaf_Person:
      foaf_givenName: Andrea
      foaf_name: Navas-Olive, Andrea
      foaf_surname: Navas-Olive
  - foaf_Person:
      foaf_givenName: Mojtaba
      foaf_name: Tavakoli, Mojtaba
      foaf_surname: Tavakoli
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A0A06F4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7667-6854
  - foaf_Person:
      foaf_givenName: Johann G
      foaf_name: Danzl, Johann G
      foaf_surname: Danzl
      foaf_workInfoHomepage: http://www.librecat.org/personId=42EFD3B6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8559-3973
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Tomschik, Matthias
      foaf_surname: Tomschik
  - foaf_Person:
      foaf_givenName: Karl
      foaf_name: Rössler, Karl
      foaf_surname: Rössler
  - foaf_Person:
      foaf_givenName: Peter M
      foaf_name: Jonas, Peter M
      foaf_surname: Jonas
      foaf_workInfoHomepage: http://www.librecat.org/personId=353C1B58-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5001-4804
  bibo_doi: 10.1101/2024.05.02.592169
  dct_date: 2024^xs_gYear
  dct_language: eng
  dct_title: Human hippocampal CA3 uses specific functional connectivity rules for
    efficient associative memory@
...