---
res:
  bibo_abstract:
  - 'Exploring the molecular correlates of metabolic health measures may identify
    their shared and unique biological processes and pathways. Molecular proxies of
    these traits may also provide a more objective approach to their measurement.
    Here, DNA methylation (DNAm) data were used in epigenome-wide association studies
    (EWASs) and for training epigenetic scores (EpiScores) of six metabolic traits:
    body mass index (BMI), body fat percentage, waist-hip ratio, and blood-based measures
    of glucose, high-density lipoprotein cholesterol, and total cholesterol in >17,000
    volunteers from the Generation Scotland (GS) cohort. We observed a maximum of
    12,033 significant findings (p < 3.6 × 10−8) for BMI in a marginal linear regression
    EWAS. By contrast, a joint and conditional Bayesian penalized regression approach
    yielded 27 high-confidence associations with BMI. EpiScores trained in GS performed
    well in both Scottish and Singaporean test cohorts (Lothian Birth Cohort 1936
    [LBC1936] and Health for Life in Singapore [HELIOS]). The EpiScores for BMI and
    total cholesterol performed best in HELIOS, explaining 20.8% and 7.1% of the variance
    in the measured traits, respectively. The corresponding results in LBC1936 were
    14.4% and 3.2%, respectively. Differences were observed in HELIOS for body fat,
    where the EpiScore explained ∼9% of the variance in Chinese and Malay -subgroups
    but ∼3% in the Indian subgroup. The EpiScores also correlated with cognitive function
    in LBC1936 (standardized βrange: 0.08–0.12, false discovery rate p [pFDR] < 0.05).
    Accounting for the correlation structure across the methylome can vastly affect
    the number of lead findings in EWASs. The EpiScores of metabolic traits are broadly
    applicable across populations and can reflect differences in cognition.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Hannah M.
      foaf_name: Smith, Hannah M.
      foaf_surname: Smith
  - foaf_Person:
      foaf_givenName: Hong Kiat
      foaf_name: Ng, Hong Kiat
      foaf_surname: Ng
  - foaf_Person:
      foaf_givenName: Joanna E.
      foaf_name: Moodie, Joanna E.
      foaf_surname: Moodie
  - foaf_Person:
      foaf_givenName: Danni A.
      foaf_name: Gadd, Danni A.
      foaf_surname: Gadd
  - foaf_Person:
      foaf_givenName: Daniel L.
      foaf_name: Mccartney, Daniel L.
      foaf_surname: Mccartney
  - foaf_Person:
      foaf_givenName: Elena
      foaf_name: Bernabeu, Elena
      foaf_surname: Bernabeu
  - foaf_Person:
      foaf_givenName: Archie
      foaf_name: Campbell, Archie
      foaf_surname: Campbell
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Redmond, Paul
      foaf_surname: Redmond
  - foaf_Person:
      foaf_givenName: Adele
      foaf_name: Taylor, Adele
      foaf_surname: Taylor
  - foaf_Person:
      foaf_givenName: Danielle
      foaf_name: Page, Danielle
      foaf_surname: Page
  - foaf_Person:
      foaf_givenName: Janie
      foaf_name: Corley, Janie
      foaf_surname: Corley
  - foaf_Person:
      foaf_givenName: Sarah E.
      foaf_name: Harris, Sarah E.
      foaf_surname: Harris
  - foaf_Person:
      foaf_givenName: Darwin
      foaf_name: Tay, Darwin
      foaf_surname: Tay
  - foaf_Person:
      foaf_givenName: Ian J.
      foaf_name: Deary, Ian J.
      foaf_surname: Deary
  - foaf_Person:
      foaf_givenName: Kathryn L.
      foaf_name: Evans, Kathryn L.
      foaf_surname: Evans
  - foaf_Person:
      foaf_givenName: Matthew Richard
      foaf_name: Robinson, Matthew Richard
      foaf_surname: Robinson
      foaf_workInfoHomepage: http://www.librecat.org/personId=E5D42276-F5DA-11E9-8E24-6303E6697425
    orcid: 0000-0001-8982-8813
  - foaf_Person:
      foaf_givenName: John C.
      foaf_name: Chambers, John C.
      foaf_surname: Chambers
  - foaf_Person:
      foaf_givenName: Marie
      foaf_name: Loh, Marie
      foaf_surname: Loh
  - foaf_Person:
      foaf_givenName: Simon R.
      foaf_name: Cox, Simon R.
      foaf_surname: Cox
  - foaf_Person:
      foaf_givenName: Riccardo E.
      foaf_name: Marioni, Riccardo E.
      foaf_surname: Marioni
  - foaf_Person:
      foaf_givenName: Robert F.
      foaf_name: Hillary, Robert F.
      foaf_surname: Hillary
  bibo_doi: 10.1016/j.ajhg.2024.11.012
  bibo_issue: '1'
  bibo_volume: 112
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001412498600001
  dct_isPartOf:
  - http://id.crossref.org/issn/0002-9297
  - http://id.crossref.org/issn/1537-6605
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: DNA methylation-based predictors of metabolic traits in Scottish and
    Singaporean cohorts@
  fabio_hasPubmedId: '39706196'
...