---
res:
  bibo_abstract:
  - Developing tissues interpret dynamic changes in morphogen activity to generate
    cell type diversity. To quantitatively study bone morphogenetic protein (BMP)
    signaling dynamics in the mouse neural tube, we developed an embryonic stem cell
    differentiation system tailored for growing tissues. Differentiating cells form
    striking self-organized patterns of dorsal neural tube cell types driven by sequential
    phases of BMP signaling that are observed both in vitro and in vivo. Data-driven
    biophysical modeling showed that these dynamics result from coupling fast negative
    feedback with slow positive regulation of signaling by the specification of an
    endogenous BMP source. Thus, in contrast to relays that propagate morphogen signaling
    in space, we identify a BMP signaling relay that operates in time. This mechanism
    allows for a rapid initial concentration-sensitive response that is robustly terminated,
    thereby regulating balanced sequential cell type generation. Our study provides
    an experimental and theoretical framework to understand how signaling dynamics
    are exploited in developing tissues.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Stefanie
      foaf_name: Rus, Stefanie
      foaf_surname: Rus
      foaf_workInfoHomepage: http://www.librecat.org/personId=4D9EC9B6-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8703-1093
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Brückner, David
      foaf_surname: Brückner
      foaf_workInfoHomepage: http://www.librecat.org/personId=e1e86031-6537-11eb-953a-f7ab92be508d
    orcid: 0000-0001-7205-2975
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Minchington, Thomas
      foaf_surname: Minchington
      foaf_workInfoHomepage: http://www.librecat.org/personId=7d1648cb-19e9-11eb-8e7a-f8c037fb3e3f
  - foaf_Person:
      foaf_givenName: Martina
      foaf_name: Greunz, Martina
      foaf_surname: Greunz
      foaf_workInfoHomepage: http://www.librecat.org/personId=48A59534-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Jack
      foaf_name: Merrin, Jack
      foaf_surname: Merrin
      foaf_workInfoHomepage: http://www.librecat.org/personId=4515C308-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5145-4609
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Anna
      foaf_name: Kicheva, Anna
      foaf_surname: Kicheva
      foaf_workInfoHomepage: http://www.librecat.org/personId=3959A2A0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4509-4998
  bibo_doi: 10.1016/j.devcel.2024.10.024
  bibo_issue: '4'
  bibo_volume: 60
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001434279000001
  dct_isPartOf:
  - http://id.crossref.org/issn/1534-5807
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: Self-organized pattern formation in the developing mouse neural tube
    by a temporal relay of BMP signaling@
  fabio_hasPubmedId: '39603235'
...