---
res:
  bibo_abstract:
  - The assembly of biomolecular condensate in eukaryotic cells and the accumulation
    of amyloid deposits in neurons are processes involving the nucleation and growth
    (NAG) of new protein phases. To therapeutically target protein phase separation,
    drug candidates are tested in in vitro assays that monitor the increase in the
    mass or size of the new phase. Limited mechanistic insight is, however, provided
    if empirical or untestable kinetic models are fitted to these progress curves.
    Here we present the web server NAGPKin that quantifies NAG rates using mass-based
    or size-based progress curves as the input data. A report is generated containing
    the fitted NAG parameters and elucidating the phase separation mechanisms at play.
    The NAG parameters can be used to predict particle size distributions of, for
    example, protein droplets formed by liquid-liquid phase separation (LLPS) or amyloid
    fibrils formed by protein aggregation. Because minimal intervention is required
    from the user, NAGPKin is a good platform for standardized reporting of LLPS and
    protein self-assembly data. NAGPKin is useful for drug discovery as well as for
    fundamental studies on protein phase separation. NAGPKin is freely available (no
    login required) at https://nagpkin.i3s.up.pt .@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Zsuzsa
      foaf_name: Sárkány, Zsuzsa
      foaf_surname: Sárkány
  - foaf_Person:
      foaf_givenName: Francisco
      foaf_name: Figueiredo, Francisco
      foaf_surname: Figueiredo
      foaf_workInfoHomepage: http://www.librecat.org/personId=8125cbe2-9661-11ed-a754-afe96018f37d
  - foaf_Person:
      foaf_givenName: Sandra
      foaf_name: Macedo-Ribeiro, Sandra
      foaf_surname: Macedo-Ribeiro
  - foaf_Person:
      foaf_givenName: Pedro M.
      foaf_name: Martins, Pedro M.
      foaf_surname: Martins
  bibo_doi: 10.1091/mbc.e23-07-0289
  bibo_issue: '3'
  bibo_volume: 35
  dct_date: 2024^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1059-1524
  - http://id.crossref.org/issn/1939-4586
  dct_language: eng
  dct_publisher: American Society for Cell Biology@
  dct_title: 'NAGPKin: Nucleation-and-growth parameters from the kinetics of protein
    phase separation@'
  fabio_hasPubmedId: '38117593'
...