---
res:
  bibo_abstract:
  - A major obstacle to predictive understanding of evolution stems from the complexity
    of biological systems, which prevents detailed characterization of key evolutionary
    properties. Here, we highlight some of the major sources of complexity that arise
    when relating molecular mechanisms to their evolutionary consequences and ask
    whether accounting for every mechanistic detail is important to accurately predict
    evolutionary outcomes. To do this, we developed a mechanistic model of a bacterial
    promoter regulated by 2 proteins, allowing us to connect any promoter genotype
    to 6 phenotypes that capture the dynamics of gene expression following an environmental
    switch. Accounting for the mechanisms that govern how this system works enabled
    us to provide an in-depth picture of how regulated bacterial promoters might evolve.
    More importantly, we used the model to explore which factors that contribute to
    the complexity of this system are essential for understanding its evolution, and
    which can be simplified without information loss. We found that several key evolutionary
    properties—the distribution of phenotypic and fitness effects of mutations, the
    evolutionary trajectories during selection for regulation—can be accurately captured
    without accounting for all, or even most, parameters of the system. Our findings
    point to the need for a mechanistic approach to studying evolution, as it enables
    tackling biological complexity and in doing so improves the ability to predict
    evolutionary outcomes.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Rok
      foaf_name: Grah, Rok
      foaf_surname: Grah
      foaf_workInfoHomepage: http://www.librecat.org/personId=483E70DE-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2539-3560
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  - foaf_Person:
      foaf_givenName: Gašper
      foaf_name: Tkačik, Gašper
      foaf_surname: Tkačik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Mato
      foaf_name: Lagator, Mato
      foaf_surname: Lagator
      foaf_workInfoHomepage: http://www.librecat.org/personId=345D25EC-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.1093/genetics/iyae191
  bibo_issue: '2'
  bibo_volume: 229
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001379194200001
  dct_isPartOf:
  - http://id.crossref.org/issn/1943-2631
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: 'Linking molecular mechanisms to their evolutionary consequences: a primer@'
  fabio_hasPubmedId: '39601269'
...