---
res:
  bibo_abstract:
  - 'Biopolymer length regulation is a complex process that involves a large number
    of biological, chemical, and physical subprocesses acting simultaneously across
    multiple spatial and temporal scales. An illustrative example important for genomic
    stability is the length regulation of telomeres - nucleoprotein structures at
    the ends of linear chromosomes consisting of tandemly repeated DNA sequences and
    a specialized set of proteins. Maintenance of telomeres is often facilitated by
    the enzyme telomerase but, particularly in telomerase-free systems, the maintenance
    of chromosomal termini depends on alternative lengthening of telomeres (ALT) mechanisms
    mediated by recombination. Various linear and circular DNA structures were identified
    to participate in ALT, however, dynamics of the whole process is still poorly
    understood. We propose a chemical kinetics model of ALT with kinetic rates systematically
    derived from the biophysics of DNA diffusion and looping. The reaction system
    is reduced to a coagulation-fragmentation system by quasi-steady-state approximation.
    The detailed treatment of kinetic rates yields explicit formulas for expected
    size distributions of telomeres that demonstrate the key role played by the J
    factor, a quantitative measure of bending of polymers. The results are in agreement
    with experimental data and point out interesting phenomena: an appearance of very
    long telomeric circles if the total telomere density exceeds a critical value
    (excess mass) and a nonlinear response of the telomere size distributions to the
    amount of telomeric DNA in the system. The results can be of general importance
    for understanding dynamics of telomeres in telomerase-independent systems as this
    mode of telomere maintenance is similar to the situation in tumor cells lacking
    telomerase activity. Furthermore, due to its universality, the model may also
    serve as a prototype of an interaction between linear and circular DNA structures
    in various settings.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Richard
      foaf_name: Kollár, Richard
      foaf_surname: Kollár
  - foaf_Person:
      foaf_givenName: Katarína
      foaf_name: Bod'ová, Katarína
      foaf_surname: Bod'ová
      foaf_workInfoHomepage: http://www.librecat.org/personId=2BA24EA0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7214-0171
  - foaf_Person:
      foaf_givenName: Jozef
      foaf_name: Nosek, Jozef
      foaf_surname: Nosek
  - foaf_Person:
      foaf_givenName: Ľubomír
      foaf_name: Tomáška, Ľubomír
      foaf_surname: Tomáška
  bibo_doi: 10.1103/PhysRevE.89.032701
  bibo_issue: '3'
  bibo_volume: 89
  dct_date: 2014^xs_gYear
  dct_identifier:
  - UT:000332274100002
  dct_language: eng
  dct_publisher: American Institute of Physics@
  dct_title: Mathematical model of alternative mechanism of telomere length maintenance@
...