---
res:
  bibo_abstract:
  - Asymmetric cell divisions allow stem cells to balance proliferation and differentiation.
    During embryogenesis, murine epidermis expands rapidly from a single layer of
    unspecified basal layer progenitors to a stratified, differentiated epithelium.
    Morphogenesis involves perpendicular (asymmetric) divisions and the spindle orientation
    protein LGN, but little is known about how the apical localization of LGN is regulated.
    Here, we combine conventional genetics and lentiviral-mediated in vivo RNAi to
    explore the functions of the LGN-interacting proteins Par3, mInsc and Gα i3. Whereas
    loss of each gene alone leads to randomized division angles, combined loss of
    Gnai3 and mInsc causes a phenotype of mostly planar divisions, akin to loss of
    LGN. These findings lend experimental support for the hitherto untested model
    that Par3-mInsc and Gα i3 act cooperatively to polarize LGN and promote perpendicular
    divisions. Finally, we uncover a developmental switch between delamination-driven
    early stratification and spindle-orientation-dependent differentiation that occurs
    around E15, revealing a two-step mechanism underlying epidermal maturation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Scott
      foaf_name: Williams, Scott
      foaf_surname: Williams
  - foaf_Person:
      foaf_givenName: Lyndsay
      foaf_name: Ratliff, Lyndsay
      foaf_surname: Ratliff
  - foaf_Person:
      foaf_givenName: Maria P
      foaf_name: Postiglione, Maria P
      foaf_surname: Postiglione
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C67902A-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Juergen
      foaf_name: Knoblich, Juergen
      foaf_surname: Knoblich
  - foaf_Person:
      foaf_givenName: Elaine
      foaf_name: Fuchs, Elaine
      foaf_surname: Fuchs
  bibo_doi: 10.1038/ncb3001
  bibo_issue: '8'
  bibo_volume: 16
  dct_date: 2014^xs_gYear
  dct_identifier:
  - UT:000339904900008
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: Par3-mInsc and Gα i3 cooperate to promote oriented epidermal cell divisions
    through LGN@
  fabio_hasPubmedId: '25016959'
...