---
res:
  bibo_abstract:
  - In plants, the patterning of stem cell-enriched meristems requires a graded auxin
    response maximum that emerges from the concerted action of polar auxin transport,
    auxin biosynthesis, auxin metabolism, and cellular auxin response machinery. However,
    mechanisms underlying this auxin response maximum-mediated root stem cell maintenance
    are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED
    HOMEOBOX 5 (WOX5) transcription factor modulates expression of auxin biosynthetic
    genes in the quiescent center (QC) of the root and thus provides a robust mechanism
    for the maintenance of auxin response maximum in the root tip. This WOX5 action
    is balanced through the activity of indole-3-acetic acid 17 (IAA17) auxin response
    repressor. Our combined genetic, cell biology, and computational modeling studies
    revealed a previously uncharacterized feedback loop linking WOX5-mediated auxin
    production to IAA17-dependent repression of auxin responses. This WOX5-IAA17 feedback
    circuit further assures the maintenance of auxin response maximum in the root
    tip and thereby contributes to the maintenance of distal stem cell (DSC) populations.
    Our experimental studies and in silico computer simulations both demonstrate that
    the WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient
    in the root tip and the auxin-mediated root DSC differentiation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Huiyu
      foaf_name: Tian, Huiyu
      foaf_surname: Tian
  - foaf_Person:
      foaf_givenName: Krzysztof T
      foaf_name: Wabnik, Krzysztof T
      foaf_surname: Wabnik
  - foaf_Person:
      foaf_givenName: Tiantian
      foaf_name: Niu, Tiantian
      foaf_surname: Niu
  - foaf_Person:
      foaf_givenName: Hongjiang
      foaf_name: Li, Hongjiang
      foaf_surname: Li
  - foaf_Person:
      foaf_givenName: Qianqian
      foaf_name: Yu, Qianqian
      foaf_surname: Yu
  - foaf_Person:
      foaf_givenName: Stephan
      foaf_name: Pollmann, Stephan
      foaf_surname: Pollmann
  - foaf_Person:
      foaf_givenName: Steffen
      foaf_name: Vanneste, Steffen
      foaf_surname: Vanneste
  - foaf_Person:
      foaf_givenName: Willy
      foaf_name: Govaerts, Willy
      foaf_surname: Govaerts
  - foaf_Person:
      foaf_givenName: Jakub
      foaf_name: Rolčík, Jakub
      foaf_surname: Rolčík
  - foaf_Person:
      foaf_givenName: Markus
      foaf_name: Geisler, Markus
      foaf_surname: Geisler
  - foaf_Person:
      foaf_givenName: Jirí
      foaf_name: Friml, Jirí
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  - foaf_Person:
      foaf_givenName: Zhaojun
      foaf_name: Ding, Zhaojun
      foaf_surname: Ding
  bibo_doi: 10.1093/mp/sst118
  bibo_issue: '2'
  bibo_volume: 7
  dct_date: 2014^xs_gYear
  dct_identifier:
  - UT:000330841400003
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial
    for the patterning of root stem cell niches in arabidopsis@
...