---
_id: '1901'
abstract:
- lang: eng
  text: In plants, the patterning of stem cell-enriched meristems requires a graded
    auxin response maximum that emerges from the concerted action of polar auxin transport,
    auxin biosynthesis, auxin metabolism, and cellular auxin response machinery. However,
    mechanisms underlying this auxin response maximum-mediated root stem cell maintenance
    are not fully understood. Here, we present unexpected evidence that WUSCHEL-RELATED
    HOMEOBOX 5 (WOX5) transcription factor modulates expression of auxin biosynthetic
    genes in the quiescent center (QC) of the root and thus provides a robust mechanism
    for the maintenance of auxin response maximum in the root tip. This WOX5 action
    is balanced through the activity of indole-3-acetic acid 17 (IAA17) auxin response
    repressor. Our combined genetic, cell biology, and computational modeling studies
    revealed a previously uncharacterized feedback loop linking WOX5-mediated auxin
    production to IAA17-dependent repression of auxin responses. This WOX5-IAA17 feedback
    circuit further assures the maintenance of auxin response maximum in the root
    tip and thereby contributes to the maintenance of distal stem cell (DSC) populations.
    Our experimental studies and in silico computer simulations both demonstrate that
    the WOX5-IAA17 feedback circuit is essential for the maintenance of auxin gradient
    in the root tip and the auxin-mediated root DSC differentiation.
acknowledgement: "This work was supported by funding from the projects CZ.1.07/2.3.00/20.0043
  and CZ.1.05/1.1.00/02.0068 (to CEITEC, Central European Institute of Technology)
  and the Odysseus program of the Research Foundation-Flanders to J.F\r\n"
article_processing_charge: No
author:
- first_name: Huiyu
  full_name: Tian, Huiyu
  last_name: Tian
- first_name: Krzysztof T
  full_name: Wabnik, Krzysztof T
  last_name: Wabnik
- first_name: Tiantian
  full_name: Niu, Tiantian
  last_name: Niu
- first_name: Hongjiang
  full_name: Li, Hongjiang
  last_name: Li
- first_name: Qianqian
  full_name: Yu, Qianqian
  last_name: Yu
- first_name: Stephan
  full_name: Pollmann, Stephan
  last_name: Pollmann
- first_name: Steffen
  full_name: Vanneste, Steffen
  last_name: Vanneste
- first_name: Willy
  full_name: Govaerts, Willy
  last_name: Govaerts
- first_name: Jakub
  full_name: Rolčík, Jakub
  last_name: Rolčík
- first_name: Markus
  full_name: Geisler, Markus
  last_name: Geisler
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Zhaojun
  full_name: Ding, Zhaojun
  last_name: Ding
citation:
  ama: Tian H, Wabnik KT, Niu T, et al. WOX5-IAA17 feedback circuit-mediated cellular
    auxin response is crucial for the patterning of root stem cell niches in arabidopsis.
    <i>Molecular Plant</i>. 2014;7(2):277-289. doi:<a href="https://doi.org/10.1093/mp/sst118">10.1093/mp/sst118</a>
  apa: Tian, H., Wabnik, K. T., Niu, T., Li, H., Yu, Q., Pollmann, S., … Ding, Z.
    (2014). WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial
    for the patterning of root stem cell niches in arabidopsis. <i>Molecular Plant</i>.
    Oxford University Press. <a href="https://doi.org/10.1093/mp/sst118">https://doi.org/10.1093/mp/sst118</a>
  chicago: Tian, Huiyu, Krzysztof T Wabnik, Tiantian Niu, Hongjiang Li, Qianqian Yu,
    Stephan Pollmann, Steffen Vanneste, et al. “WOX5-IAA17 Feedback Circuit-Mediated
    Cellular Auxin Response Is Crucial for the Patterning of Root Stem Cell Niches
    in Arabidopsis.” <i>Molecular Plant</i>. Oxford University Press, 2014. <a href="https://doi.org/10.1093/mp/sst118">https://doi.org/10.1093/mp/sst118</a>.
  ieee: H. Tian <i>et al.</i>, “WOX5-IAA17 feedback circuit-mediated cellular auxin
    response is crucial for the patterning of root stem cell niches in arabidopsis,”
    <i>Molecular Plant</i>, vol. 7, no. 2. Oxford University Press, pp. 277–289, 2014.
  ista: Tian H, Wabnik KT, Niu T, Li H, Yu Q, Pollmann S, Vanneste S, Govaerts W,
    Rolčík J, Geisler M, Friml J, Ding Z. 2014. WOX5-IAA17 feedback circuit-mediated
    cellular auxin response is crucial for the patterning of root stem cell niches
    in arabidopsis. Molecular Plant. 7(2), 277–289.
  mla: Tian, Huiyu, et al. “WOX5-IAA17 Feedback Circuit-Mediated Cellular Auxin Response
    Is Crucial for the Patterning of Root Stem Cell Niches in Arabidopsis.” <i>Molecular
    Plant</i>, vol. 7, no. 2, Oxford University Press, 2014, pp. 277–89, doi:<a href="https://doi.org/10.1093/mp/sst118">10.1093/mp/sst118</a>.
  short: H. Tian, K.T. Wabnik, T. Niu, H. Li, Q. Yu, S. Pollmann, S. Vanneste, W.
    Govaerts, J. Rolčík, M. Geisler, J. Friml, Z. Ding, Molecular Plant 7 (2014) 277–289.
date_created: 2018-12-11T11:54:37Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2025-09-29T12:30:56Z
day: '01'
department:
- _id: JiFr
doi: 10.1093/mp/sst118
external_id:
  isi:
  - '000330841400003'
fulldoi: https://doi.org/10.1093/mp/sst118
intvolume: '         7'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 277 - 289
publication: Molecular Plant
publication_status: published
publisher: Oxford University Press
publist_id: '5194'
scopus_import: '1'
status: public
title: WOX5-IAA17 feedback circuit-mediated cellular auxin response is crucial for
  the patterning of root stem cell niches in arabidopsis
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 7
year: '2014'
...