---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19037'
abstract:
- lang: eng
  text: We present a novel, portable sensor platform that enables concurrent monitoring
    of surface mass and charge density variations at thin biointerfaces. This platform
    combines a coplanar-gated field-effect transistor (FET) architecture with grating-coupled
    surface plasmon resonance (SPR), yielding an integrated disposable sensor chip
    prepared by nanoimprint and maskless photolithography techniques. The sensor chip
    design is suitable for scalable production and relies on reduced graphene oxide
    (rGO), serving as the FET’s semiconductor material for the electronic readout,
    and a metallic gate electrode surface that is corrugated with a multi-diffractive
    structure for optical probing with resonantly excited surface plasmons. Together
    with its integration in a compact instrumentation this results in a form factor
    optimized solution for dual-mode investigations without compromising the optical
    or electronic sensor performance. A poly-L-lysine (PLL) – based thin linker layer
    was deployed at the sensor surface to covalently attach azide-conjugated biomolecules
    by using incorporated “clickable” dibenzocyclooctyne (DBCO) moieties. Interestingly,
    the dual-mode measurements allow elucidating the role of the globular nature of
    the PLL chains when increasing the density of DBCO attached to their backbone,
    leading to PLL folding and internalization of DBCO moieties, and thus reducing
    the coupling yield for the used DNA oligomers. We envision that this platform
    can be employed to studying a range of other biointerface architectures and biomolecular
    interaction phenomena, which are inherently tied to mass and charge density variations.
acknowledged_ssus:
- _id: EM-Fac
acknowledgement: We thank the Electron Microscopy Facility at ISTA for their support
  with sputter coating the FO probes and NOSI GmbH for their support with 3D printing.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Roger
  full_name: Hasler, Roger
  last_name: Hasler
- first_name: Pietro A.
  full_name: Livio, Pietro A.
  last_name: Livio
- first_name: Anil
  full_name: Bozdogan, Anil
  last_name: Bozdogan
- first_name: Stefan
  full_name: Fossati, Stefan
  last_name: Fossati
- first_name: Simone
  full_name: Hageneder, Simone
  last_name: Hageneder
- first_name: Verónica
  full_name: Montes-García, Verónica
  last_name: Montes-García
- first_name: Jacopo
  full_name: Movilli, Jacopo
  last_name: Movilli
- first_name: Taghi
  full_name: Moazzenzade, Taghi
  last_name: Moazzenzade
- first_name: Luna
  full_name: Loohuis, Luna
  last_name: Loohuis
- first_name: Ciril
  full_name: Reiner-Rozman, Ciril
  last_name: Reiner-Rozman
- first_name: Adrián
  full_name: Tamayo, Adrián
  last_name: Tamayo
- first_name: Christine
  full_name: Fiedler, Christine
  id: bd3fceba-dc74-11ea-a0a7-c17f71817366
  last_name: Fiedler
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
- first_name: Christoph
  full_name: Kleber, Christoph
  last_name: Kleber
- first_name: Jurriaan
  full_name: Huskens, Jurriaan
  last_name: Huskens
- first_name: Jakub
  full_name: Dostalek, Jakub
  last_name: Dostalek
- first_name: Paolo
  full_name: Samorì, Paolo
  last_name: Samorì
- first_name: Wolfgang
  full_name: Knoll, Wolfgang
  last_name: Knoll
citation:
  ama: Hasler R, Livio PA, Bozdogan A, et al. Dual electronic and optical monitoring
    of biointerfaces by a grating-structured coplanar-gated field-effect transistor.
    <i>IEEE Sensors Journal</i>. 2025;25(7):10521-10529. doi:<a href="https://doi.org/10.1109/jsen.2025.3533113">10.1109/jsen.2025.3533113</a>
  apa: Hasler, R., Livio, P. A., Bozdogan, A., Fossati, S., Hageneder, S., Montes-García,
    V., … Knoll, W. (2025). Dual electronic and optical monitoring of biointerfaces
    by a grating-structured coplanar-gated field-effect transistor. <i>IEEE Sensors
    Journal</i>. IEEE. <a href="https://doi.org/10.1109/jsen.2025.3533113">https://doi.org/10.1109/jsen.2025.3533113</a>
  chicago: Hasler, Roger, Pietro A. Livio, Anil Bozdogan, Stefan Fossati, Simone Hageneder,
    Verónica Montes-García, Jacopo Movilli, et al. “Dual Electronic and Optical Monitoring
    of Biointerfaces by a Grating-Structured Coplanar-Gated Field-Effect Transistor.”
    <i>IEEE Sensors Journal</i>. IEEE, 2025. <a href="https://doi.org/10.1109/jsen.2025.3533113">https://doi.org/10.1109/jsen.2025.3533113</a>.
  ieee: R. Hasler <i>et al.</i>, “Dual electronic and optical monitoring of biointerfaces
    by a grating-structured coplanar-gated field-effect transistor,” <i>IEEE Sensors
    Journal</i>, vol. 25, no. 7. IEEE, pp. 10521–10529, 2025.
  ista: Hasler R, Livio PA, Bozdogan A, Fossati S, Hageneder S, Montes-García V, Movilli
    J, Moazzenzade T, Loohuis L, Reiner-Rozman C, Tamayo A, Fiedler C, Ibáñez M, Kleber
    C, Huskens J, Dostalek J, Samorì P, Knoll W. 2025. Dual electronic and optical
    monitoring of biointerfaces by a grating-structured coplanar-gated field-effect
    transistor. IEEE Sensors Journal. 25(7), 10521–10529.
  mla: Hasler, Roger, et al. “Dual Electronic and Optical Monitoring of Biointerfaces
    by a Grating-Structured Coplanar-Gated Field-Effect Transistor.” <i>IEEE Sensors
    Journal</i>, vol. 25, no. 7, IEEE, 2025, pp. 10521–29, doi:<a href="https://doi.org/10.1109/jsen.2025.3533113">10.1109/jsen.2025.3533113</a>.
  short: R. Hasler, P.A. Livio, A. Bozdogan, S. Fossati, S. Hageneder, V. Montes-García,
    J. Movilli, T. Moazzenzade, L. Loohuis, C. Reiner-Rozman, A. Tamayo, C. Fiedler,
    M. Ibáñez, C. Kleber, J. Huskens, J. Dostalek, P. Samorì, W. Knoll, IEEE Sensors
    Journal 25 (2025) 10521–10529.
date_created: 2025-02-17T09:22:26Z
date_published: 2025-04-01T00:00:00Z
date_updated: 2026-02-16T11:50:01Z
day: '01'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1109/jsen.2025.3533113
external_id:
  isi:
  - '001457747000001'
file:
- access_level: open_access
  checksum: 9cdd4017025a3add6198ed84798319e8
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  creator: dernst
  date_created: 2025-12-30T07:59:13Z
  date_updated: 2025-12-30T07:59:13Z
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file_date_updated: 2025-12-30T07:59:13Z
has_accepted_license: '1'
intvolume: '        25'
isi: 1
issue: '7'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 10521-10529
publication: IEEE Sensors Journal
publication_identifier:
  eissn:
  - 1558-1748
  issn:
  - 1530-437X
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dual electronic and optical monitoring of biointerfaces by a grating-structured
  coplanar-gated field-effect transistor
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 25
year: '2025'
...