A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics

article A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics published yes Tomas A Vega Zuniga author 2E7C4E78-F248-11E8-B48F-1D18A9856A87 Anton L Sumser author 3320A096-F248-11E8-B48F-1D18A9856A870000-0002-4792-1881 Olga Symonova author 3C0C7BC6-F248-11E8-B48F-1D18A9856A870000-0003-2012-9947 Peter Koppensteiner author 3B8B25A8-F248-11E8-B48F-1D18A9856A870000-0002-3509-1948 Florian Schmidt author A2EF226A-AF19-11E9-924C-0525E6697425 Maximilian A Jösch author 2BD278E6-F248-11E8-B48F-1D18A9856A870000-0002-3937-1330 MaJö department PreCl department Circuits of Visual Attention project Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses project Connecting sensory with motor processing in the superior colliculus project Neuronal networks of salience and spatial detection in the murine superior colliculus project For accurate perception and motor control, an animal must distinguish between sensory experiences elicited by external stimuli and those elicited by its own actions. The diversity of behaviors and their complex influences on the senses make this distinction challenging. Here, we uncover an action–cue hub that coordinates motor commands with visual processing in the brain’s first visual relay. We show that the ventral lateral geniculate nucleus (vLGN) acts as a corollary discharge center, integrating visual translational optic flow signals with motor copies from saccades, locomotion and pupil dynamics. The vLGN relays these signals to correct action-specific visual distortions and to refine perception, as shown for the superior colliculus and in a depth-estimation task. Simultaneously, brain-wide vLGN projections drive corrective actions necessary for accurate visuomotor control. Our results reveal an extended corollary discharge architecture that refines early visual transformations and coordinates actions via a distributed hub-and-spoke network to enable visual perception during action. Springer Nature2025 eng Nature Neuroscience 1097-6256 1546-1726 39930095 00141686680000110.1038/s41593-025-01874-w 28 https://research-explorer.ista.ac.at/record/18579 https://ista.ac.at/en/news/high-tech-video-optimization-in-our-brain/ Vega Zuniga, T. A., Sumser, A. L., Symonova, O., Koppensteiner, P., Schmidt, F., & Jösch, M. A. (2025). A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Nature Neuroscience. Springer Nature. <a href="https://doi.org/10.1038/s41593-025-01874-w">https://doi.org/10.1038/s41593-025-01874-w</a> T. A. Vega Zuniga, A. L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, and M. A. Jösch, “A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics,” Nature Neuroscience, vol. 28. Springer Nature, 2025. Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. 2025. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Nature Neuroscience. 28, 7278. Vega Zuniga, Tomas A., et al. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” Nature Neuroscience, vol. 28, 7278, Springer Nature, 2025, doi:<a href="https://doi.org/10.1038/s41593-025-01874-w">10.1038/s41593-025-01874-w</a>. Vega Zuniga, Tomas A, Anton L Sumser, Olga Symonova, Peter Koppensteiner, Florian Schmidt, and Maximilian A Jösch. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” Nature Neuroscience. Springer Nature, 2025. <a href="https://doi.org/10.1038/s41593-025-01874-w">https://doi.org/10.1038/s41593-025-01874-w</a>. Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Nature Neuroscience. 2025;28. doi:<a href="https://doi.org/10.1038/s41593-025-01874-w">10.1038/s41593-025-01874-w</a> T.A. Vega Zuniga, A.L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, M.A. Jösch, Nature Neuroscience 28 (2025). 190762025-02-23T23:01:58Z2026-06-18T18:12:08Z