---
OA_place: publisher
OA_type: hybrid
_id: '19076'
abstract:
- lang: eng
  text: For accurate perception and motor control, an animal must distinguish between
    sensory experiences elicited by external stimuli and those elicited by its own
    actions. The diversity of behaviors and their complex influences on the senses
    make this distinction challenging. Here, we uncover an action–cue hub that coordinates
    motor commands with visual processing in the brain’s first visual relay. We show
    that the ventral lateral geniculate nucleus (vLGN) acts as a corollary discharge
    center, integrating visual translational optic flow signals with motor copies
    from saccades, locomotion and pupil dynamics. The vLGN relays these signals to
    correct action-specific visual distortions and to refine perception, as shown
    for the superior colliculus and in a depth-estimation task. Simultaneously, brain-wide
    vLGN projections drive corrective actions necessary for accurate visuomotor control.
    Our results reveal an extended corollary discharge architecture that refines early
    visual transformations and coordinates actions via a distributed hub-and-spoke
    network to enable visual perception during action.
acknowledged_ssus:
- _id: ScienComp
- _id: PreCl
- _id: LifeSc
- _id: Bio
acknowledgement: We thank Y. Ben-Simon for generously making viral vectors for retrograde
  tracing available, as well as J. Watson and F. Marr for reagents. We also thank
  R. Shigemoto, W. Młynarski and members of the Neuroethology group for their comments
  on the manuscript and L. Burnett for her schematic drawings. This research was supported
  by the Scientific Service Units of ISTA through resources provided by Scientific
  Computing, the Preclinical Facility, the Lab Support Facility and the Imaging and
  Optics Facility, in particular F. Lange, M. Schunn and T. Asenov. This work was
  supported by European Research Council Starting Grant no. 756502 (M.J.) and European
  Research Council Consolidator Grant no. 101086580 (M.J.); and EMBO ALTF grant no.
  1098-2017 (A.S.) and Human Frontiers Science Program grant no. LT000256/2018-L (A.S.).
  Open access funding provided by Institute of Science and Technology (IST Austria).
article_number: '7278'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Tomas A
  full_name: Vega Zuniga, Tomas A
  id: 2E7C4E78-F248-11E8-B48F-1D18A9856A87
  last_name: Vega Zuniga
- first_name: Anton L
  full_name: Sumser, Anton L
  id: 3320A096-F248-11E8-B48F-1D18A9856A87
  last_name: Sumser
  orcid: 0000-0002-4792-1881
- first_name: Olga
  full_name: Symonova, Olga
  id: 3C0C7BC6-F248-11E8-B48F-1D18A9856A87
  last_name: Symonova
  orcid: 0000-0003-2012-9947
- first_name: Peter
  full_name: Koppensteiner, Peter
  id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87
  last_name: Koppensteiner
  orcid: 0000-0002-3509-1948
- first_name: Florian
  full_name: Schmidt, Florian
  id: A2EF226A-AF19-11E9-924C-0525E6697425
  last_name: Schmidt
- first_name: Maximilian A
  full_name: Jösch, Maximilian A
  id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
  last_name: Jösch
  orcid: 0000-0002-3937-1330
citation:
  ama: Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA.
    A thalamic hub-and-spoke network enables visual perception during action by coordinating
    visuomotor dynamics. <i>Nature Neuroscience</i>. 2025;28. doi:<a href="https://doi.org/10.1038/s41593-025-01874-w">10.1038/s41593-025-01874-w</a>
  apa: Vega Zuniga, T. A., Sumser, A. L., Symonova, O., Koppensteiner, P., Schmidt,
    F., &#38; Jösch, M. A. (2025). A thalamic hub-and-spoke network enables visual
    perception during action by coordinating visuomotor dynamics. <i>Nature Neuroscience</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41593-025-01874-w">https://doi.org/10.1038/s41593-025-01874-w</a>
  chicago: Vega Zuniga, Tomas A, Anton L Sumser, Olga Symonova, Peter Koppensteiner,
    Florian Schmidt, and Maximilian A Jösch. “A Thalamic Hub-and-Spoke Network Enables
    Visual Perception during Action by Coordinating Visuomotor Dynamics.” <i>Nature
    Neuroscience</i>. Springer Nature, 2025. <a href="https://doi.org/10.1038/s41593-025-01874-w">https://doi.org/10.1038/s41593-025-01874-w</a>.
  ieee: T. A. Vega Zuniga, A. L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt,
    and M. A. Jösch, “A thalamic hub-and-spoke network enables visual perception during
    action by coordinating visuomotor dynamics,” <i>Nature Neuroscience</i>, vol.
    28. Springer Nature, 2025.
  ista: Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA.
    2025. A thalamic hub-and-spoke network enables visual perception during action
    by coordinating visuomotor dynamics. Nature Neuroscience. 28, 7278.
  mla: Vega Zuniga, Tomas A., et al. “A Thalamic Hub-and-Spoke Network Enables Visual
    Perception during Action by Coordinating Visuomotor Dynamics.” <i>Nature Neuroscience</i>,
    vol. 28, 7278, Springer Nature, 2025, doi:<a href="https://doi.org/10.1038/s41593-025-01874-w">10.1038/s41593-025-01874-w</a>.
  short: T.A. Vega Zuniga, A.L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt,
    M.A. Jösch, Nature Neuroscience 28 (2025).
corr_author: '1'
date_created: 2025-02-23T23:01:58Z
date_published: 2025-03-01T00:00:00Z
date_updated: 2026-06-18T18:12:08Z
day: '01'
ddc:
- '570'
department:
- _id: MaJö
- _id: PreCl
doi: 10.1038/s41593-025-01874-w
ec_funded: 1
external_id:
  isi:
  - '001416866800001'
  pmid:
  - '39930095'
fulldoi: https://doi.org/10.1038/s41593-025-01874-w
has_accepted_license: '1'
intvolume: '        28'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41593-025-01874-w
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2634E9D2-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '756502'
  name: Circuits of Visual Attention
- _id: bdaf81a8-d553-11ed-ba76-c95961984540
  grant_number: '101086580'
  name: 'Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses'
- _id: 264FEA02-B435-11E9-9278-68D0E5697425
  grant_number: ALTF 1098-2017
  name: Connecting sensory with motor processing in the superior colliculus
- _id: 266D407A-B435-11E9-9278-68D0E5697425
  grant_number: LT000256
  name: Neuronal networks of salience and spatial detection in the murine superior
    colliculus
publication: Nature Neuroscience
publication_identifier:
  eissn:
  - 1546-1726
  issn:
  - 1097-6256
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA Website
    relation: press_release
    url: https://ista.ac.at/en/news/high-tech-video-optimization-in-our-brain/
  record:
  - id: '18579'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: A thalamic hub-and-spoke network enables visual perception during action by
  coordinating visuomotor dynamics
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2025'
...