---
res:
  bibo_abstract:
  - angerhans cells (LCs) are a unique subset of dendritic cells (DCs) that express
    epithelial adhesion molecules, allowing them to form contacts with epithelial
    cells and reside in epidermal/epithelial tissues. The dynamic regulation of epithelial
    adhesion plays a decisive role in the life cycle of LCs. It controls whether LCs
    remain immature and sessile within the epidermis or mature and egress to initiate
    immune responses. So far, the molecular machinery regulating epithelial adhesion
    molecules during LC maturation remains elusive. Here, we generated pure populations
    of immature human LCs in vitro to systematically probe for gene-expression changes
    during LC maturation. LCs down-regulate a set of epithelial genes including E-cadherin,
    while they upregulate the mesenchymal marker N-cadherin known to facilitate cell
    migration. In addition, N-cadherin is constitutively expressed by monocyte-derived
    DCs known to exhibit characteristics of both inflammatory-type and interstitial/dermal
    DCs. Moreover, the transcription factors ZEB1 and ZEB2 (ZEB is zinc-finger E-box-binding
    homeobox) are upregulated in migratory LCs. ZEB1 and ZEB2 have been shown to induce
    epithelial-to-mesenchymal transition (EMT) and invasive behavior in cancer cells
    undergoing metastasis. Our results provide the first hint that the molecular EMT
    machinery might facilitate LC mobilization. Moreover, our study suggests that
    N-cadherin plays a role during DC migration.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Sabine
      foaf_name: Konradi, Sabine
      foaf_surname: Konradi
  - foaf_Person:
      foaf_givenName: Nighat
      foaf_name: Yasmin, Nighat
      foaf_surname: Yasmin
  - foaf_Person:
      foaf_givenName: Denise
      foaf_name: Haslwanter, Denise
      foaf_surname: Haslwanter
  - foaf_Person:
      foaf_givenName: Michele
      foaf_name: Weber, Michele
      foaf_surname: Weber
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A3FC708-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Bernd
      foaf_name: Gesslbauer, Bernd
      foaf_surname: Gesslbauer
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  - foaf_Person:
      foaf_givenName: Herbert
      foaf_name: Strobl, Herbert
      foaf_surname: Strobl
  bibo_doi: 10.1002/eji.201343681
  bibo_issue: '2'
  bibo_volume: 44
  dct_date: 2014^xs_gYear
  dct_identifier:
  - UT:000331901200025
  dct_language: eng
  dct_publisher: Wiley-Blackwell@
  dct_title: Langerhans cell maturation is accompanied by induction of N-cadherin
    and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2@
...