---
_id: '1910'
abstract:
- lang: eng
  text: angerhans cells (LCs) are a unique subset of dendritic cells (DCs) that express
    epithelial adhesion molecules, allowing them to form contacts with epithelial
    cells and reside in epidermal/epithelial tissues. The dynamic regulation of epithelial
    adhesion plays a decisive role in the life cycle of LCs. It controls whether LCs
    remain immature and sessile within the epidermis or mature and egress to initiate
    immune responses. So far, the molecular machinery regulating epithelial adhesion
    molecules during LC maturation remains elusive. Here, we generated pure populations
    of immature human LCs in vitro to systematically probe for gene-expression changes
    during LC maturation. LCs down-regulate a set of epithelial genes including E-cadherin,
    while they upregulate the mesenchymal marker N-cadherin known to facilitate cell
    migration. In addition, N-cadherin is constitutively expressed by monocyte-derived
    DCs known to exhibit characteristics of both inflammatory-type and interstitial/dermal
    DCs. Moreover, the transcription factors ZEB1 and ZEB2 (ZEB is zinc-finger E-box-binding
    homeobox) are upregulated in migratory LCs. ZEB1 and ZEB2 have been shown to induce
    epithelial-to-mesenchymal transition (EMT) and invasive behavior in cancer cells
    undergoing metastasis. Our results provide the first hint that the molecular EMT
    machinery might facilitate LC mobilization. Moreover, our study suggests that
    N-cadherin plays a role during DC migration.
acknowledgement: 'FWF. Grant Number: P22058-B20'
article_processing_charge: No
author:
- first_name: Sabine
  full_name: Konradi, Sabine
  last_name: Konradi
- first_name: Nighat
  full_name: Yasmin, Nighat
  last_name: Yasmin
- first_name: Denise
  full_name: Haslwanter, Denise
  last_name: Haslwanter
- first_name: Michele
  full_name: Weber, Michele
  id: 3A3FC708-F248-11E8-B48F-1D18A9856A87
  last_name: Weber
- first_name: Bernd
  full_name: Gesslbauer, Bernd
  last_name: Gesslbauer
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
- first_name: Herbert
  full_name: Strobl, Herbert
  last_name: Strobl
citation:
  ama: Konradi S, Yasmin N, Haslwanter D, et al. Langerhans cell maturation is accompanied
    by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal
    transition ZEB1/2. <i>European Journal of Immunology</i>. 2014;44(2):553-560.
    doi:<a href="https://doi.org/10.1002/eji.201343681">10.1002/eji.201343681</a>
  apa: Konradi, S., Yasmin, N., Haslwanter, D., Weber, M., Gesslbauer, B., Sixt, M.
    K., &#38; Strobl, H. (2014). Langerhans cell maturation is accompanied by induction
    of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition
    ZEB1/2. <i>European Journal of Immunology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1002/eji.201343681">https://doi.org/10.1002/eji.201343681</a>
  chicago: Konradi, Sabine, Nighat Yasmin, Denise Haslwanter, Michele Weber, Bernd
    Gesslbauer, Michael K Sixt, and Herbert Strobl. “Langerhans Cell Maturation Is
    Accompanied by Induction of N-Cadherin and the Transcriptional Regulators of Epithelial-Mesenchymal
    Transition ZEB1/2.” <i>European Journal of Immunology</i>. Wiley-Blackwell, 2014.
    <a href="https://doi.org/10.1002/eji.201343681">https://doi.org/10.1002/eji.201343681</a>.
  ieee: S. Konradi <i>et al.</i>, “Langerhans cell maturation is accompanied by induction
    of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition
    ZEB1/2,” <i>European Journal of Immunology</i>, vol. 44, no. 2. Wiley-Blackwell,
    pp. 553–560, 2014.
  ista: Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt MK, Strobl
    H. 2014. Langerhans cell maturation is accompanied by induction of N-cadherin
    and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.
    European Journal of Immunology. 44(2), 553–560.
  mla: Konradi, Sabine, et al. “Langerhans Cell Maturation Is Accompanied by Induction
    of N-Cadherin and the Transcriptional Regulators of Epithelial-Mesenchymal Transition
    ZEB1/2.” <i>European Journal of Immunology</i>, vol. 44, no. 2, Wiley-Blackwell,
    2014, pp. 553–60, doi:<a href="https://doi.org/10.1002/eji.201343681">10.1002/eji.201343681</a>.
  short: S. Konradi, N. Yasmin, D. Haslwanter, M. Weber, B. Gesslbauer, M.K. Sixt,
    H. Strobl, European Journal of Immunology 44 (2014) 553–560.
date_created: 2018-12-11T11:54:40Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2025-09-29T12:26:01Z
day: '01'
department:
- _id: MiSi
doi: 10.1002/eji.201343681
external_id:
  isi:
  - '000331901200025'
intvolume: '        44'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa_version: None
page: 553 - 560
publication: European Journal of Immunology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5185'
scopus_import: '1'
status: public
title: Langerhans cell maturation is accompanied by induction of N-cadherin and the
  transcriptional regulators of epithelial-mesenchymal transition ZEB1/2
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 44
year: '2014'
...