{"acknowledgement":"Supported by the Deutsche Forschungsgemeinschaft (G.N.)","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157572/","open_access":"1"}],"year":"2014","oa_version":"Submitted Version","pmid":1,"month":"01","article_type":"original","title":"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders","intvolume":"       343","publisher":"American Association for the Advancement of Science","publication_status":"published","date_updated":"2021-01-12T06:54:03Z","quality_controlled":"1","abstract":[{"lang":"eng","text":"Hereditary spastic paraplegias (HSPs) are neurodegenerative motor neuron diseases characterized by progressive age-dependent loss of corticospinal motor tract function. Although the genetic basis is partly understood, only a fraction of cases can receive a genetic diagnosis, and a global view of HSP is lacking. By using whole-exome sequencing in combination with network analysis, we identified 18 previously unknown putative HSP genes and validated nearly all of these genes functionally or genetically. The pathways highlighted by these mutations link HSP to cellular transport, nucleotide metabolism, and synapse and axon development. Network analysis revealed a host of further candidate genes, of which three were mutated in our cohort. Our analysis links HSP to other neurodegenerative disorders and can facilitate gene discovery and mechanistic understanding of disease."}],"language":[{"iso":"eng"}],"date_published":"2014-01-31T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2018-12-11T11:54:42Z","issue":"6170","external_id":{"pmid":["24482476"]},"volume":343,"scopus_import":1,"publication":"Science","page":"506 - 511","citation":{"ista":"Novarino G, Fenstermaker A, Zaki M, Hofree M, Silhavy J, Heiberg A, Abdellateef M, Rosti B, Scott E, Mansour L, Masri A, Kayserili H, Al Aama J, Abdel Salam G, Karminejad A, Kara M, Kara B, Bozorgmehri B, Ben Omran T, Mojahedi F, Mahmoud I, Bouslam N, Bouhouche A, Benomar A, Hanein S, Raymond L, Forlani S, Mascaro M, Selim L, Shehata N, Al Allawi N, Bindu P, Azam M, Günel M, Caglayan A, Bilgüvar K, Tolun A, Issa M, Schroth J, Spencer E, Rosti R, Akizu N, Vaux K, Johansen A, Koh A, Megahed H, Dürr A, Brice A, Stévanin G, Gabriel S, Ideker T, Gleeson J. 2014. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science. 343(6170), 506–511.","ama":"Novarino G, Fenstermaker A, Zaki M, et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. <i>Science</i>. 2014;343(6170):506-511. doi:<a href=\"https://doi.org/10.1126/science.1247363\">10.1126/science.1247363</a>","ieee":"G. Novarino <i>et al.</i>, “Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders,” <i>Science</i>, vol. 343, no. 6170. American Association for the Advancement of Science, pp. 506–511, 2014.","mla":"Novarino, Gaia, et al. “Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders.” <i>Science</i>, vol. 343, no. 6170, American Association for the Advancement of Science, 2014, pp. 506–11, doi:<a href=\"https://doi.org/10.1126/science.1247363\">10.1126/science.1247363</a>.","chicago":"Novarino, Gaia, Ali Fenstermaker, Maha Zaki, Matan Hofree, Jennifer Silhavy, Andrew Heiberg, Mostafa Abdellateef, et al. “Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders.” <i>Science</i>. American Association for the Advancement of Science, 2014. <a href=\"https://doi.org/10.1126/science.1247363\">https://doi.org/10.1126/science.1247363</a>.","short":"G. Novarino, A. Fenstermaker, M. Zaki, M. Hofree, J. Silhavy, A. Heiberg, M. Abdellateef, B. Rosti, E. Scott, L. Mansour, A. Masri, H. Kayserili, J. Al Aama, G. Abdel Salam, A. Karminejad, M. Kara, B. Kara, B. Bozorgmehri, T. Ben Omran, F. Mojahedi, I. Mahmoud, N. Bouslam, A. Bouhouche, A. Benomar, S. Hanein, L. Raymond, S. Forlani, M. Mascaro, L. Selim, N. Shehata, N. Al Allawi, P. Bindu, M. Azam, M. Günel, A. Caglayan, K. Bilgüvar, A. Tolun, M. Issa, J. Schroth, E. Spencer, R. Rosti, N. Akizu, K. Vaux, A. Johansen, A. Koh, H. Megahed, A. Dürr, A. Brice, G. Stévanin, S. Gabriel, T. Ideker, J. Gleeson, Science 343 (2014) 506–511.","apa":"Novarino, G., Fenstermaker, A., Zaki, M., Hofree, M., Silhavy, J., Heiberg, A., … Gleeson, J. (2014). Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1247363\">https://doi.org/10.1126/science.1247363</a>"},"status":"public","type":"journal_article","publist_id":"5178","department":[{"_id":"GaNo"}],"doi":"10.1126/science.1247363","day":"31","author":[{"first_name":"Gaia","full_name":"Novarino, Gaia","last_name":"Novarino","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Ali","full_name":"Fenstermaker, Ali","last_name":"Fenstermaker"},{"full_name":"Zaki, Maha","first_name":"Maha","last_name":"Zaki"},{"first_name":"Matan","full_name":"Hofree, Matan","last_name":"Hofree"},{"last_name":"Silhavy","first_name":"Jennifer","full_name":"Silhavy, Jennifer"},{"last_name":"Heiberg","full_name":"Heiberg, Andrew","first_name":"Andrew"},{"last_name":"Abdellateef","first_name":"Mostafa","full_name":"Abdellateef, Mostafa"},{"first_name":"Başak","full_name":"Rosti, Başak","last_name":"Rosti"},{"last_name":"Scott","first_name":"Eric","full_name":"Scott, Eric"},{"last_name":"Mansour","full_name":"Mansour, Lobna","first_name":"Lobna"},{"last_name":"Masri","full_name":"Masri, Amira","first_name":"Amira"},{"last_name":"Kayserili","full_name":"Kayserili, Hülya","first_name":"Hülya"},{"last_name":"Al Aama","full_name":"Al Aama, Jumana","first_name":"Jumana"},{"last_name":"Abdel Salam","full_name":"Abdel Salam, Ghada","first_name":"Ghada"},{"last_name":"Karminejad","full_name":"Karminejad, Ariana","first_name":"Ariana"},{"last_name":"Kara","first_name":"Majdi","full_name":"Kara, Majdi"},{"first_name":"Bülent","full_name":"Kara, Bülent","last_name":"Kara"},{"last_name":"Bozorgmehri","full_name":"Bozorgmehri, Bita","first_name":"Bita"},{"full_name":"Ben Omran, Tawfeg","first_name":"Tawfeg","last_name":"Ben Omran"},{"last_name":"Mojahedi","full_name":"Mojahedi, Faezeh","first_name":"Faezeh"},{"full_name":"Mahmoud, Iman","first_name":"Iman","last_name":"Mahmoud"},{"last_name":"Bouslam","full_name":"Bouslam, Naïma","first_name":"Naïma"},{"full_name":"Bouhouche, Ahmed","first_name":"Ahmed","last_name":"Bouhouche"},{"first_name":"Ali","full_name":"Benomar, Ali","last_name":"Benomar"},{"last_name":"Hanein","full_name":"Hanein, Sylvain","first_name":"Sylvain"},{"last_name":"Raymond","full_name":"Raymond, Laure","first_name":"Laure"},{"last_name":"Forlani","full_name":"Forlani, Sylvie","first_name":"Sylvie"},{"last_name":"Mascaro","first_name":"Massimo","full_name":"Mascaro, Massimo"},{"first_name":"Laila","full_name":"Selim, Laila","last_name":"Selim"},{"first_name":"Nabil","full_name":"Shehata, Nabil","last_name":"Shehata"},{"last_name":"Al Allawi","full_name":"Al Allawi, Nasir","first_name":"Nasir"},{"last_name":"Bindu","first_name":"Parayil","full_name":"Bindu, Parayil"},{"last_name":"Azam","first_name":"Matloob","full_name":"Azam, Matloob"},{"last_name":"Günel","first_name":"Murat","full_name":"Günel, Murat"},{"full_name":"Caglayan, Ahmet","first_name":"Ahmet","last_name":"Caglayan"},{"first_name":"Kaya","full_name":"Bilgüvar, Kaya","last_name":"Bilgüvar"},{"last_name":"Tolun","full_name":"Tolun, Aslihan","first_name":"Aslihan"},{"last_name":"Issa","full_name":"Issa, Mahmoud","first_name":"Mahmoud"},{"first_name":"Jana","full_name":"Schroth, Jana","last_name":"Schroth"},{"full_name":"Spencer, Emily","first_name":"Emily","last_name":"Spencer"},{"full_name":"Rosti, Rasim","first_name":"Rasim","last_name":"Rosti"},{"full_name":"Akizu, Naiara","first_name":"Naiara","last_name":"Akizu"},{"last_name":"Vaux","full_name":"Vaux, Keith","first_name":"Keith"},{"last_name":"Johansen","first_name":"Anide","full_name":"Johansen, Anide"},{"last_name":"Koh","full_name":"Koh, Alice","first_name":"Alice"},{"last_name":"Megahed","first_name":"Hisham","full_name":"Megahed, Hisham"},{"last_name":"Dürr","full_name":"Dürr, Alexandra","first_name":"Alexandra"},{"first_name":"Alexis","full_name":"Brice, Alexis","last_name":"Brice"},{"last_name":"Stévanin","full_name":"Stévanin, Giovanni","first_name":"Giovanni"},{"last_name":"Gabriel","full_name":"Gabriel, Stacy","first_name":"Stacy"},{"full_name":"Ideker, Trey","first_name":"Trey","last_name":"Ideker"},{"last_name":"Gleeson","full_name":"Gleeson, Joseph","first_name":"Joseph"}],"article_processing_charge":"No","_id":"1916","oa":1}