---
res:
  bibo_abstract:
  - In the past decade carbon nanotubes (CNTs) have been widely studied as a potential
    drug-delivery system, especially with functionality for cellular targeting. Yet,
    little is known about the actual process of docking to cell receptors and transport
    dynamics after internalization. Here we performed single-particle studies of folic
    acid (FA) mediated CNT binding to human carcinoma cells and their transport inside
    the cytosol. In particular, we employed molecular recognition force spectroscopy,
    an atomic force microscopy based method, to visualize and quantify docking of
    FA functionalized CNTs to FA binding receptors in terms of binding probability
    and binding force. We then traced individual fluorescently labeled, FA functionalized
    CNTs after specific uptake, and created a dynamic 'roadmap' that clearly showed
    trajectories of directed diffusion and areas of nanotube confinement in the cytosol.
    Our results demonstrate the potential of a single-molecule approach for investigation
    of drug-delivery vehicles and their targeting capacity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Constanze
      foaf_name: Lamprecht, Constanze
      foaf_surname: Lamprecht
  - foaf_Person:
      foaf_givenName: Birgit
      foaf_name: Plochberger, Birgit
      foaf_surname: Plochberger
  - foaf_Person:
      foaf_givenName: Verena
      foaf_name: Ruprecht, Verena
      foaf_surname: Ruprecht
      foaf_workInfoHomepage: http://www.librecat.org/personId=4D71A03A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4088-8633
  - foaf_Person:
      foaf_givenName: Stefan
      foaf_name: Wieser, Stefan
      foaf_surname: Wieser
      foaf_workInfoHomepage: http://www.librecat.org/personId=355AA5A0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-2670-2217
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Rankl, Christian
      foaf_surname: Rankl
  - foaf_Person:
      foaf_givenName: Elena
      foaf_name: Heister, Elena
      foaf_surname: Heister
  - foaf_Person:
      foaf_givenName: Barbara
      foaf_name: Unterauer, Barbara
      foaf_surname: Unterauer
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: Brameshuber, Mario
      foaf_surname: Brameshuber
  - foaf_Person:
      foaf_givenName: Jürgen
      foaf_name: Danzberger, Jürgen
      foaf_surname: Danzberger
  - foaf_Person:
      foaf_givenName: Petar
      foaf_name: Lukanov, Petar
      foaf_surname: Lukanov
  - foaf_Person:
      foaf_givenName: Emmanuel
      foaf_name: Flahaut, Emmanuel
      foaf_surname: Flahaut
  - foaf_Person:
      foaf_givenName: Gerhard
      foaf_name: Schütz, Gerhard
      foaf_surname: Schütz
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Hinterdorfer, Peter
      foaf_surname: Hinterdorfer
  - foaf_Person:
      foaf_givenName: Andreas
      foaf_name: Ebner, Andreas
      foaf_surname: Ebner
  bibo_doi: 10.1088/0957-4484/25/12/125704
  bibo_issue: '12'
  bibo_volume: 25
  dct_date: 2014^xs_gYear
  dct_identifier:
  - UT:000332669300017
  dct_language: eng
  dct_publisher: IOP Publishing@
  dct_title: A single-molecule approach to explore binding uptake and transport of
    cancer cell targeting nanotubes@
...