{"abstract":[{"lang":"eng","text":"Light-driven molecular rotary motors perform chirality-controlled unidirectional rotations fueled by light and heat. This unique function renders them appealing for the construction of dynamic molecular systems, actuating materials, and molecular machines. Achieving a combination of high photoefficiency, visible-light responsiveness, synthetic accessibility, and easy tuning of dynamic properties within a single scaffold is critical for these applications but remains a longstanding challenge. Herein, a series of highly photoefficient visible-light–responsive molecular motors (MMs), featuring various rotary speeds, was obtained by a convenient one-step formylation of their parent motors. This strategy greatly improves all aspects of the performance of MMs—red-shifted wavelengths of excitation, high photoisomerization quantum yields, and high photostationary state distributions of isomers—beyond the state-of-the-art light-responsive MM systems. The development of this late-stage functionalization strategy of MMs opens avenues for the construction of high-performance molecular machines and devices for applications in materials science and biological systems, representing a major advance in the synthetic toolbox of molecular machines."}],"file_date_updated":"2025-03-04T10:57:39Z","day":"21","date_updated":"2025-03-04T10:59:53Z","article_number":"eadr9326","_id":"19277","volume":11,"type":"journal_article","file":[{"success":1,"date_updated":"2025-03-04T10:57:39Z","file_id":"19293","creator":"dernst","date_created":"2025-03-04T10:57:39Z","relation":"main_file","checksum":"34ad18a07cb87fdde7bdb626fdeef832","content_type":"application/pdf","access_level":"open_access","file_size":584613,"file_name":"2025_ScienceAdvance_Sheng.pdf"}],"DOAJ_listed":"1","publication":"Science Advances","title":"General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light","department":[{"_id":"RaKl"}],"external_id":{"pmid":["39970219"]},"pmid":1,"acknowledgement":"R. Sneep is acknowledged for mass spectral analysis and SFC training. We thank A. S. Lubbe from University of Groningen for help with this manuscript and for fruitful discussions. We thank P. Cieciórski from University of Warsaw for help with the figure preparation. This work was supported from the following sources: China Scholarship Council, CSC PhD Fellowship no. 201808330459 to J.S.; the Netherlands Organization for Scientific Research (NWO-CW) (B.L.F); the Dutch Ministry of Education, Culture, and Science (Gravitation program no. 024.001.035) (B.L.F.); Polish National Agency for Academic Exchange (reg. no.: BPN/PPO/2023/1/00014); and National Science Center Poland (reg. no.: 2024/03/1/ST5/00003) (W.D.).","month":"02","oa":1,"oa_version":"Published Version","date_published":"2025-02-21T00:00:00Z","has_accepted_license":"1","quality_controlled":"1","publication_status":"published","scopus_import":"1","OA_place":"publisher","article_processing_charge":"Yes","citation":{"chicago":"Sheng, Jinyu, Carlijn L.F. Van Beek, Charlotte N. Stindt, Wojciech Danowski, Joanna Jankowska, Stefano Crespi, Daisy R.S. Pooler, Michiel F. Hilbers, Wybren Jan Buma, and Ben L. Feringa. “General Strategy for Boosting the Performance of Speed-Tunable Rotary Molecular Motors with Visible Light.” <i>Science Advances</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/sciadv.adr9326\">https://doi.org/10.1126/sciadv.adr9326</a>.","ista":"Sheng J, Van Beek CLF, Stindt CN, Danowski W, Jankowska J, Crespi S, Pooler DRS, Hilbers MF, Buma WJ, Feringa BL. 2025. General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light. Science Advances. 11(8), eadr9326.","short":"J. Sheng, C.L.F. Van Beek, C.N. Stindt, W. Danowski, J. Jankowska, S. Crespi, D.R.S. Pooler, M.F. Hilbers, W.J. Buma, B.L. Feringa, Science Advances 11 (2025).","ama":"Sheng J, Van Beek CLF, Stindt CN, et al. General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light. <i>Science Advances</i>. 2025;11(8). doi:<a href=\"https://doi.org/10.1126/sciadv.adr9326\">10.1126/sciadv.adr9326</a>","apa":"Sheng, J., Van Beek, C. L. F., Stindt, C. N., Danowski, W., Jankowska, J., Crespi, S., … Feringa, B. L. (2025). General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.adr9326\">https://doi.org/10.1126/sciadv.adr9326</a>","ieee":"J. Sheng <i>et al.</i>, “General strategy for boosting the performance of speed-tunable rotary molecular motors with visible light,” <i>Science Advances</i>, vol. 11, no. 8. AAAS, 2025.","mla":"Sheng, Jinyu, et al. “General Strategy for Boosting the Performance of Speed-Tunable Rotary Molecular Motors with Visible Light.” <i>Science Advances</i>, vol. 11, no. 8, eadr9326, AAAS, 2025, doi:<a href=\"https://doi.org/10.1126/sciadv.adr9326\">10.1126/sciadv.adr9326</a>."},"author":[{"id":"639f0526-27c9-11ee-95a6-966cd7f102d8","full_name":"Sheng, Jinyu","last_name":"Sheng","first_name":"Jinyu"},{"first_name":"Carlijn L.F.","last_name":"Van Beek","full_name":"Van Beek, Carlijn L.F."},{"last_name":"Stindt","full_name":"Stindt, Charlotte N.","first_name":"Charlotte N."},{"first_name":"Wojciech","full_name":"Danowski, Wojciech","last_name":"Danowski"},{"first_name":"Joanna","full_name":"Jankowska, Joanna","last_name":"Jankowska"},{"last_name":"Crespi","full_name":"Crespi, Stefano","first_name":"Stefano"},{"first_name":"Daisy R.S.","full_name":"Pooler, Daisy R.S.","last_name":"Pooler"},{"full_name":"Hilbers, Michiel F.","last_name":"Hilbers","first_name":"Michiel F."},{"first_name":"Wybren Jan","full_name":"Buma, Wybren Jan","last_name":"Buma"},{"last_name":"Feringa","full_name":"Feringa, Ben L.","first_name":"Ben L."}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)"},"issue":"8","language":[{"iso":"eng"}],"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"gold","publisher":"AAAS","intvolume":"        11","ddc":["540"],"article_type":"original","year":"2025","publication_identifier":{"eissn":["2375-2548"]},"doi":"10.1126/sciadv.adr9326","date_created":"2025-03-02T23:01:51Z"}