---
res:
  bibo_abstract:
  - Reproducible pattern and form generation during embryogenesis is poorly understood.
    Intestinal organoid morphogenesis involves a number of mechanochemical regulators
    such as cell-type-specific cytoskeletal forces and osmotically driven lumen volume
    changes. It is unclear how these forces are coordinated in time and space to ensure
    robust morphogenesis. Here we show how mechanosensitive feedback on cytoskeletal
    tension gives rise to morphological bistability in a minimal model of organoid
    morphogenesis. In the model, lumen volume changes can impact the epithelial shape
    via both direct mechanical and indirect mechanosensitive mechanisms. We find that
    both bulged and budded crypt states are possible and dependent on the history
    of volume changes. We test key modelling assumptions via biophysical and pharmacological
    experiments to demonstrate how bistability can explain experimental observations,
    such as the importance of the timing of lumen shrinkage and robustness of the
    final morphogenetic state to mechanical perturbations. This suggests that bistability
    arising from feedback between cellular tensions and fluid pressure could be a
    general mechanism that coordinates multicellular shape changes in developing systems.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Shi-lei
      foaf_name: Xue, Shi-lei
      foaf_surname: Xue
      foaf_workInfoHomepage: http://www.librecat.org/personId=31D2C804-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Qiutan
      foaf_name: Yang, Qiutan
      foaf_surname: Yang
  - foaf_Person:
      foaf_givenName: Prisca
      foaf_name: Liberali, Prisca
      foaf_surname: Liberali
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  bibo_doi: 10.1038/s41567-025-02792-1
  bibo_volume: 21
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001434072800001
  dct_isPartOf:
  - http://id.crossref.org/issn/1745-2473
  - http://id.crossref.org/issn/1745-2481
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Mechanochemical bistability of intestinal organoids enables robust morphogenesis@
  fabio_hasPubmedId: '40248571'
...