---
OA_place: publisher
_id: '19395'
abstract:
- lang: eng
text: "Plant growth and development rely significantly on phytohormones, with auxin
serving as a master regulator, orchestrating processes from embryogenesis to organogenesis,
vascular patterning, and environmental adaptation. Since its conceptual proposition
by Charles Darwin in 1880 as an endogenous chemical signal influencing phototropism
in grass, auxin has captivated scientists seeking to understand how such a small
molecule exerts a profound influence on plant development.\r\nOne particularly
fascinating aspect of auxin function is its ability to self-organize its transport.
Through a feedback mechanism between auxin perception and directional transport—primarily
mediated by PIN auxin transporters—auxin establishes narrow transport channels.
This phenomenon, known as auxin canalization, is fundamental to vascular formation,
regeneration, and other key developmental processes. Despite advances in our understanding,
driven by experimental studies and computational models, auxin canalization remains
an enigma, with many unanswered questions.\r\nLike other hormones, auxin functions
through intricate signaling pathways. It operates through at least two distinct
signaling mechanisms: the well-characterized canonical pathway and the less understood
non-canonical pathway. While significant progress has been made in elucidating
the canonical pathway, the non-canonical mechanisms remain less defined and require
further investigation.\r\nIn this study, we revisit the non-canonical auxin signaling
pathway mediated by the cell-surface complex Auxin Binding Protein 1-Transmembrane
Kinase 1 (ABP1-TMK1), with a particular focus on its downstream phosphorylation
events. We reveal that this auxin-mediated phosphorylation is conserved across
the green lineage, underscoring its fundamental role in plant development. We
explore key phosphorylation targets, particularly PIN2, which is essential for
root gravitropism. To further understand TMK1’s role in diverse developmental
processes, we identified and investigated its interactors as potential co-receptors
or regulatory components within its signaling network.\r\nGiven the previously
established role of ABP1-TMK1 in auxin canalization, we sought to further investigate
this process and identified several TMK1 interactors also involved in this intricate
mechanism.\r\nThese findings provide new insights into the complex regulation
of auxin canalization, highlighting a broader and more interconnected signaling
framework than previously understood."
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
acknowledgement: I would like to acknowledge the facilities at ISTA, particularly
LSF, IOF, and, of course, the plant facility, for providing the necessary resources
for my research.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Aline
full_name: Monzer, Aline
id: 2DB5D88C-D7B3-11E9-B8FD-7907E6697425
last_name: Monzer
citation:
ama: 'Monzer A. Cell-Surface Auxin Signaling: Linking molecular pathways to plant
development. 2025. doi:10.15479/AT-ISTA-19395'
apa: 'Monzer, A. (2025). Cell-Surface Auxin Signaling: Linking molecular pathways
to plant development. Institute of Science and Technology Austria. https://doi.org/10.15479/AT-ISTA-19395'
chicago: 'Monzer, Aline. “Cell-Surface Auxin Signaling: Linking Molecular Pathways
to Plant Development.” Institute of Science and Technology Austria, 2025. https://doi.org/10.15479/AT-ISTA-19395.'
ieee: 'A. Monzer, “Cell-Surface Auxin Signaling: Linking molecular pathways to plant
development,” Institute of Science and Technology Austria, 2025.'
ista: 'Monzer A. 2025. Cell-Surface Auxin Signaling: Linking molecular pathways
to plant development. Institute of Science and Technology Austria.'
mla: 'Monzer, Aline. Cell-Surface Auxin Signaling: Linking Molecular Pathways
to Plant Development. Institute of Science and Technology Austria, 2025, doi:10.15479/AT-ISTA-19395.'
short: 'A. Monzer, Cell-Surface Auxin Signaling: Linking Molecular Pathways to Plant
Development, Institute of Science and Technology Austria, 2025.'
corr_author: '1'
date_created: 2025-03-12T14:25:42Z
date_published: 2025-03-13T00:00:00Z
date_updated: 2026-07-06T12:52:09Z
day: '13'
ddc:
- '580'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JiFr
doi: 10.15479/AT-ISTA-19395
file:
- access_level: open_access
checksum: 9a3dd03bb4ec6b9907a325c3c4e8a1d7
content_type: application/pdf
creator: amonzer
date_created: 2025-03-12T14:14:49Z
date_updated: 2025-03-12T14:14:49Z
file_id: '19396'
file_name: Final Thesis Aline Monzer.pdf
file_size: 13119670
relation: main_file
success: 1
- access_level: closed
checksum: a353ce1ee2eabce37bca35499e76dbf1
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: amonzer
date_created: 2025-03-12T14:15:19Z
date_updated: 2025-04-01T07:55:27Z
file_id: '19397'
file_name: Thesis Aline.docx
file_size: 13774837
relation: source_file
file_date_updated: 2025-04-01T07:55:27Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '160'
publication_identifier:
eisbn:
- 978-3-99078-054-1
eissn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12291'
relation: part_of_dissertation
status: public
- id: '14826'
relation: part_of_dissertation
status: public
- id: '19399'
relation: part_of_dissertation
status: public
- id: '19398'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
title: 'Cell-Surface Auxin Signaling: Linking molecular pathways to plant development'
type: dissertation
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2025'
...