{"_id":"194","publication":"The FASEB Journal","external_id":{"pmid":["29939785"],"isi":["000449359700035"]},"volume":32,"status":"public","article_type":"original","scopus_import":"1","day":"29","isi":1,"type":"journal_article","issue":"12","intvolume":"        32","oa":1,"article_processing_charge":"No","author":[{"last_name":"Liutkeviciute","first_name":"Zita","full_name":"Liutkeviciute, Zita"},{"last_name":"Gil Mansilla","full_name":"Gil Mansilla, Esther","first_name":"Esther"},{"full_name":"Eder, Thomas","first_name":"Thomas","last_name":"Eder"},{"id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","last_name":"Casillas Perez","first_name":"Barbara E","full_name":"Casillas Perez, Barbara E"},{"last_name":"Giulia Di Giglio","full_name":"Giulia Di Giglio, Maria","first_name":"Maria"},{"last_name":"Muratspahić","full_name":"Muratspahić, Edin","first_name":"Edin"},{"last_name":"Grebien","first_name":"Florian","full_name":"Grebien, Florian"},{"full_name":"Rattei, Thomas","first_name":"Thomas","last_name":"Rattei"},{"full_name":"Muttenthaler, Markus","first_name":"Markus","last_name":"Muttenthaler"},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868","first_name":"Sylvia","full_name":"Cremer, Sylvia","last_name":"Cremer"},{"last_name":"Gruber","first_name":"Christian","full_name":"Gruber, Christian"}],"oa_version":"Published Version","doi":"10.1096/fj.201800443","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"SyCr"}],"publication_identifier":{"issn":["08926638"]},"abstract":[{"text":"Ants are emerging model systems to study cellular signaling because distinct castes possess different physiologic phenotypes within the same colony. Here we studied the functionality of inotocin signaling, an insect ortholog of mammalian oxytocin (OT), which was recently discovered in ants. In Lasius ants, we determined that specialization within the colony, seasonal factors, and physiologic conditions down-regulated the expression of the OT-like signaling system. Given this natural variation, we interrogated its function using RNAi knockdowns. Next-generation RNA sequencing of OT-like precursor knock-down ants highlighted its role in the regulation of genes involved in metabolism. Knock-down ants exhibited higher walking activity and increased self-grooming in the brood chamber. We propose that OT-like signaling in ants is important for regulating metabolic processes and locomotion.","lang":"eng"}],"date_published":"2018-11-29T00:00:00Z","date_updated":"2023-09-13T09:37:32Z","year":"2018","pmid":1,"citation":{"ieee":"Z. Liutkeviciute <i>et al.</i>, “Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity,” <i>The FASEB Journal</i>, vol. 32, no. 12. FASEB, pp. 6808–6821, 2018.","ista":"Liutkeviciute Z, Gil Mansilla E, Eder T, Casillas Perez BE, Giulia Di Giglio M, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber C. 2018. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. 32(12), 6808–6821.","chicago":"Liutkeviciute, Zita, Esther Gil Mansilla, Thomas Eder, Barbara E Casillas Perez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, et al. “Oxytocin-like Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.” <i>The FASEB Journal</i>. FASEB, 2018. <a href=\"https://doi.org/10.1096/fj.201800443\">https://doi.org/10.1096/fj.201800443</a>.","apa":"Liutkeviciute, Z., Gil Mansilla, E., Eder, T., Casillas Perez, B. E., Giulia Di Giglio, M., Muratspahić, E., … Gruber, C. (2018). Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. <i>The FASEB Journal</i>. FASEB. <a href=\"https://doi.org/10.1096/fj.201800443\">https://doi.org/10.1096/fj.201800443</a>","ama":"Liutkeviciute Z, Gil Mansilla E, Eder T, et al. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. <i>The FASEB Journal</i>. 2018;32(12):6808-6821. doi:<a href=\"https://doi.org/10.1096/fj.201800443\">10.1096/fj.201800443</a>","short":"Z. Liutkeviciute, E. Gil Mansilla, T. Eder, B.E. Casillas Perez, M. Giulia Di Giglio, E. Muratspahić, F. Grebien, T. Rattei, M. Muttenthaler, S. Cremer, C. Gruber, The FASEB Journal 32 (2018) 6808–6821.","mla":"Liutkeviciute, Zita, et al. “Oxytocin-like Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.” <i>The FASEB Journal</i>, vol. 32, no. 12, FASEB, 2018, pp. 6808–21, doi:<a href=\"https://doi.org/10.1096/fj.201800443\">10.1096/fj.201800443</a>."},"project":[{"name":"Individual function and social role of oxytocin-like neuropeptides in ants","_id":"25E3D34E-B435-11E9-9278-68D0E5697425"}],"publisher":"FASEB","main_file_link":[{"url":" https://doi.org/10.1096/fj.201800443","open_access":"1"}],"publist_id":"7721","publication_status":"published","month":"11","language":[{"iso":"eng"}],"quality_controlled":"1","title":"Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity","date_created":"2018-12-11T11:45:08Z","page":"6808-6821"}