article published yes Ste Tavano author 2F162F0C-F248-11E8-B48F-1D18A9856A870000-0001-9970-7804 David Brückner author e1e86031-6537-11eb-953a-f7ab92be508d0000-0001-7205-2975 Saren Tasciyan author 4323B49C-F248-11E8-B48F-1D18A9856A870000-0003-1671-393X Xin Tong author 50F65CDC-AA30-11E9-A72B-8A12E6697425 Roland Kardos author 4039350E-F248-11E8-B48F-1D18A9856A87 Alexandra Schauer author 30A536BA-F248-11E8-B48F-1D18A9856A870000-0001-7659-9142 Robert Hauschild author 4E01D6B4-F248-11E8-B48F-1D18A9856A870000-0001-9843-3522 Carl-Philipp J Heisenberg author 39427864-F248-11E8-B48F-1D18A9856A870000-0002-0912-4566 CaHe department EdHa department MiSi department Bio department A mechano-chemical theory for stem cell fate decisions in organoid development project Mechanosensation in cell migration: the role of friction forces in cell polarization and directed migration project Cell migration is a fundamental process during embryonic development. Most studies in vivo have focused on the migration of cells using the extracellular matrix (ECM) as their substrate for migration. In contrast, much less is known about how cells migrate on other cells, as found in early embryos when the ECM has not yet formed. Here, we show that lateral mesendoderm (LME) cells in the early zebrafish gastrula use the ectoderm as their substrate for migration. We show that the lateral ectoderm is permissive for the animal-pole-directed migration of LME cells, while the ectoderm at the animal pole halts it. These differences in permissiveness depend on the lateral ectoderm being more cohesive than the animal ectoderm, a property controlled by bone morphogenetic protein (BMP) signaling within the ectoderm. Collectively, these findings identify ectoderm tissue cohesion as one critical factor in regulating LME migration during zebrafish gastrulation. https://research-explorer.ista.ac.at/download/19404/19413/2025_CellReports_Tavano.pdf application/pdfno https://creativecommons.org/licenses/by-nc-nd/4.0/ Elsevier2025 eng 2639-1856 2211-1247 40057955 00144365270000110.1016/j.celrep.2025.115387 443 S. Tavano, D. Brückner, S. Tasciyan, X. Tong, R. Kardos, A. Schauer, R. Hauschild, C.-P.J. Heisenberg, Cell Reports 44 (2025). Tavano, Ste, David Brückner, Saren Tasciyan, Xin Tong, Roland Kardos, Alexandra Schauer, Robert Hauschild, and Carl-Philipp J Heisenberg. “BMP-Dependent Patterning of Ectoderm Tissue Material Properties Modulates Lateral Mesendoderm Cell Migration during Early Zebrafish Gastrulation.” <i>Cell Reports</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.celrep.2025.115387">https://doi.org/10.1016/j.celrep.2025.115387</a>. Tavano S, Brückner D, Tasciyan S, Tong X, Kardos R, Schauer A, Hauschild R, Heisenberg C-PJ. 2025. BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. Cell Reports. 44(3), 115387. Tavano S, Brückner D, Tasciyan S, et al. BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. <i>Cell Reports</i>. 2025;44(3). doi:<a href="https://doi.org/10.1016/j.celrep.2025.115387">10.1016/j.celrep.2025.115387</a> Tavano, S., Brückner, D., Tasciyan, S., Tong, X., Kardos, R., Schauer, A., … Heisenberg, C.-P. J. (2025). BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. <i>Cell Reports</i>. Elsevier. <a href="https://doi.org/10.1016/j.celrep.2025.115387">https://doi.org/10.1016/j.celrep.2025.115387</a> Tavano, Ste, et al. “BMP-Dependent Patterning of Ectoderm Tissue Material Properties Modulates Lateral Mesendoderm Cell Migration during Early Zebrafish Gastrulation.” <i>Cell Reports</i>, vol. 44, no. 3, 115387, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.celrep.2025.115387">10.1016/j.celrep.2025.115387</a>. S. Tavano <i>et al.</i>, “BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation,” <i>Cell Reports</i>, vol. 44, no. 3. Elsevier, 2025. 194042025-03-16T23:01:24Z2025-10-22T07:00:04Z