---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19404'
abstract:
- lang: eng
  text: Cell migration is a fundamental process during embryonic development. Most
    studies in vivo have focused on the migration of cells using the extracellular
    matrix (ECM) as their substrate for migration. In contrast, much less is known
    about how cells migrate on other cells, as found in early embryos when the ECM
    has not yet formed. Here, we show that lateral mesendoderm (LME) cells in the
    early zebrafish gastrula use the ectoderm as their substrate for migration. We
    show that the lateral ectoderm is permissive for the animal-pole-directed migration
    of LME cells, while the ectoderm at the animal pole halts it. These differences
    in permissiveness depend on the lateral ectoderm being more cohesive than the
    animal ectoderm, a property controlled by bone morphogenetic protein (BMP) signaling
    within the ectoderm. Collectively, these findings identify ectoderm tissue cohesion
    as one critical factor in regulating LME migration during zebrafish gastrulation.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: ScienComp
acknowledgement: 'We are grateful to the colleagues who contributed to this work with
  discussions, technical advice, and feedback on the manuscript: Irene Steccari, David
  Labrousse Arias and the other members of the Heisenberg lab, Nicole Amberg, Florian
  Pauler, Nicoletta Petridou, Elena Scarpa, and Edouard Hannezo. We also thank the
  Imaging and Optics Facility, the Life Science Facility, and the Scientific Computing
  Unit at ISTA for support. The Next Generation Sequencing Facility at Vienna BioCenter
  Core Facilities performed the RNA-seq for animal and lateral ectoderm. D.B.B. was
  supported by the NOMIS Foundation as a NOMIS Fellow and by an EMBO Postdoctoral
  Fellowship (ALTF 343-2022). S. Tavano was supported by an EMBO Postdoctoral Fellowship
  (ALTF 1159-2018).'
article_number: '115387'
article_processing_charge: Yes
article_type: original
author:
- first_name: Ste
  full_name: Tavano, Ste
  id: 2F162F0C-F248-11E8-B48F-1D18A9856A87
  last_name: Tavano
  orcid: 0000-0001-9970-7804
- first_name: David
  full_name: Brückner, David
  id: e1e86031-6537-11eb-953a-f7ab92be508d
  last_name: Brückner
  orcid: 0000-0001-7205-2975
- first_name: Saren
  full_name: Tasciyan, Saren
  id: 4323B49C-F248-11E8-B48F-1D18A9856A87
  last_name: Tasciyan
  orcid: 0000-0003-1671-393X
- first_name: Xin
  full_name: Tong, Xin
  id: 50F65CDC-AA30-11E9-A72B-8A12E6697425
  last_name: Tong
- first_name: Roland
  full_name: Kardos, Roland
  id: 4039350E-F248-11E8-B48F-1D18A9856A87
  last_name: Kardos
- first_name: Alexandra
  full_name: Schauer, Alexandra
  id: 30A536BA-F248-11E8-B48F-1D18A9856A87
  last_name: Schauer
  orcid: 0000-0001-7659-9142
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Carl-Philipp J
  full_name: Heisenberg, Carl-Philipp J
  id: 39427864-F248-11E8-B48F-1D18A9856A87
  last_name: Heisenberg
  orcid: 0000-0002-0912-4566
citation:
  ama: Tavano S, Brückner D, Tasciyan S, et al. BMP-dependent patterning of ectoderm
    tissue material properties modulates lateral mesendoderm cell migration during
    early zebrafish gastrulation. <i>Cell Reports</i>. 2025;44(3). doi:<a href="https://doi.org/10.1016/j.celrep.2025.115387">10.1016/j.celrep.2025.115387</a>
  apa: Tavano, S., Brückner, D., Tasciyan, S., Tong, X., Kardos, R., Schauer, A.,
    … Heisenberg, C.-P. J. (2025). BMP-dependent patterning of ectoderm tissue material
    properties modulates lateral mesendoderm cell migration during early zebrafish
    gastrulation. <i>Cell Reports</i>. Elsevier. <a href="https://doi.org/10.1016/j.celrep.2025.115387">https://doi.org/10.1016/j.celrep.2025.115387</a>
  chicago: Tavano, Ste, David Brückner, Saren Tasciyan, Xin Tong, Roland Kardos, Alexandra
    Schauer, Robert Hauschild, and Carl-Philipp J Heisenberg. “BMP-Dependent Patterning
    of Ectoderm Tissue Material Properties Modulates Lateral Mesendoderm Cell Migration
    during Early Zebrafish Gastrulation.” <i>Cell Reports</i>. Elsevier, 2025. <a
    href="https://doi.org/10.1016/j.celrep.2025.115387">https://doi.org/10.1016/j.celrep.2025.115387</a>.
  ieee: S. Tavano <i>et al.</i>, “BMP-dependent patterning of ectoderm tissue material
    properties modulates lateral mesendoderm cell migration during early zebrafish
    gastrulation,” <i>Cell Reports</i>, vol. 44, no. 3. Elsevier, 2025.
  ista: Tavano S, Brückner D, Tasciyan S, Tong X, Kardos R, Schauer A, Hauschild R,
    Heisenberg C-PJ. 2025. BMP-dependent patterning of ectoderm tissue material properties
    modulates lateral mesendoderm cell migration during early zebrafish gastrulation.
    Cell Reports. 44(3), 115387.
  mla: Tavano, Ste, et al. “BMP-Dependent Patterning of Ectoderm Tissue Material Properties
    Modulates Lateral Mesendoderm Cell Migration during Early Zebrafish Gastrulation.”
    <i>Cell Reports</i>, vol. 44, no. 3, 115387, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.celrep.2025.115387">10.1016/j.celrep.2025.115387</a>.
  short: S. Tavano, D. Brückner, S. Tasciyan, X. Tong, R. Kardos, A. Schauer, R. Hauschild,
    C.-P.J. Heisenberg, Cell Reports 44 (2025).
corr_author: '1'
date_created: 2025-03-16T23:01:24Z
date_published: 2025-03-25T00:00:00Z
date_updated: 2025-10-22T07:00:04Z
day: '25'
ddc:
- '570'
department:
- _id: CaHe
- _id: EdHa
- _id: MiSi
- _id: Bio
doi: 10.1016/j.celrep.2025.115387
external_id:
  isi:
  - '001443652700001'
  pmid:
  - '40057955'
file:
- access_level: open_access
  checksum: 57e05dd1598c807af0afdb32cec039d3
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  creator: dernst
  date_created: 2025-03-17T10:26:54Z
  date_updated: 2025-03-17T10:26:54Z
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file_date_updated: 2025-03-17T10:26:54Z
has_accepted_license: '1'
intvolume: '        44'
isi: 1
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
  grant_number: ALTF 343-2022
  name: A mechano-chemical theory for stem cell fate decisions in organoid development
- _id: 269CD5C4-B435-11E9-9278-68D0E5697425
  grant_number: ALTF 1159-2018
  name: 'Mechanosensation in cell migration: the role of friction forces in cell polarization
    and directed migration'
publication: Cell Reports
publication_identifier:
  eissn:
  - 2211-1247
  issn:
  - 2639-1856
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: BMP-dependent patterning of ectoderm tissue material properties modulates lateral
  mesendoderm cell migration during early zebrafish gastrulation
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 44
year: '2025'
...