{"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"article_processing_charge":"No","year":"2025","month":"03","scopus_import":"1","doi":"10.1038/s41586-024-08487-6","department":[{"_id":"GaNo"}],"page":"315-320","date_created":"2025-03-23T23:01:27Z","language":[{"iso":"eng"}],"_id":"19444","intvolume":"       639","type":"journal_article","author":[{"full_name":"Pașca, Sergiu P.","first_name":"Sergiu P.","last_name":"Pașca"},{"full_name":"Arlotta, Paola","first_name":"Paola","last_name":"Arlotta"},{"full_name":"Bateup, Helen S.","last_name":"Bateup","first_name":"Helen S."},{"full_name":"Camp, J. Gray","last_name":"Camp","first_name":"J. Gray"},{"first_name":"Silvia","last_name":"Cappello","full_name":"Cappello, Silvia"},{"full_name":"Gage, Fred H.","last_name":"Gage","first_name":"Fred H."},{"last_name":"Knoblich","first_name":"Jürgen A.","full_name":"Knoblich, Jürgen A."},{"full_name":"Kriegstein, Arnold R.","last_name":"Kriegstein","first_name":"Arnold R."},{"full_name":"Lancaster, Madeline A.","first_name":"Madeline A.","last_name":"Lancaster"},{"first_name":"Guo Li","last_name":"Ming","full_name":"Ming, Guo Li"},{"last_name":"Novarino","orcid":"0000-0002-7673-7178","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia"},{"full_name":"Okano, Hideyuki","first_name":"Hideyuki","last_name":"Okano"},{"full_name":"Parmar, Malin","first_name":"Malin","last_name":"Parmar"},{"first_name":"In Hyun","last_name":"Park","full_name":"Park, In Hyun"},{"first_name":"Orly","last_name":"Reiner","full_name":"Reiner, Orly"},{"full_name":"Song, Hongjun","last_name":"Song","first_name":"Hongjun"},{"full_name":"Studer, Lorenz","last_name":"Studer","first_name":"Lorenz"},{"full_name":"Takahashi, Jun","first_name":"Jun","last_name":"Takahashi"},{"full_name":"Temple, Sally","last_name":"Temple","first_name":"Sally"},{"full_name":"Testa, Giuseppe","last_name":"Testa","first_name":"Giuseppe"},{"full_name":"Treutlein, Barbara","first_name":"Barbara","last_name":"Treutlein"},{"first_name":"Flora M.","last_name":"Vaccarino","full_name":"Vaccarino, Flora M."},{"last_name":"Vanderhaeghen","first_name":"Pierre","full_name":"Vanderhaeghen, Pierre"},{"full_name":"Young-Pearse, Tracy","first_name":"Tracy","last_name":"Young-Pearse"}],"oa_version":"None","date_published":"2025-03-13T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"closed access","day":"13","status":"public","external_id":{"pmid":["39653126"]},"publication_status":"published","publisher":"Springer Nature","publication":"Nature","citation":{"apa":"Pașca, S. P., Arlotta, P., Bateup, H. S., Camp, J. G., Cappello, S., Gage, F. H., … Young-Pearse, T. (2025). A framework for neural organoids, assembloids and transplantation studies. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-024-08487-6\">https://doi.org/10.1038/s41586-024-08487-6</a>","mla":"Pașca, Sergiu P., et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” <i>Nature</i>, vol. 639, no. 8054, Springer Nature, 2025, pp. 315–20, doi:<a href=\"https://doi.org/10.1038/s41586-024-08487-6\">10.1038/s41586-024-08487-6</a>.","short":"S.P. Pașca, P. Arlotta, H.S. Bateup, J.G. Camp, S. Cappello, F.H. Gage, J.A. Knoblich, A.R. Kriegstein, M.A. Lancaster, G.L. Ming, G. Novarino, H. Okano, M. Parmar, I.H. Park, O. Reiner, H. Song, L. Studer, J. Takahashi, S. Temple, G. Testa, B. Treutlein, F.M. Vaccarino, P. Vanderhaeghen, T. Young-Pearse, Nature 639 (2025) 315–320.","chicago":"Pașca, Sergiu P., Paola Arlotta, Helen S. Bateup, J. Gray Camp, Silvia Cappello, Fred H. Gage, Jürgen A. Knoblich, et al. “A Framework for Neural Organoids, Assembloids and Transplantation Studies.” <i>Nature</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41586-024-08487-6\">https://doi.org/10.1038/s41586-024-08487-6</a>.","ieee":"S. P. Pașca <i>et al.</i>, “A framework for neural organoids, assembloids and transplantation studies,” <i>Nature</i>, vol. 639, no. 8054. Springer Nature, pp. 315–320, 2025.","ama":"Pașca SP, Arlotta P, Bateup HS, et al. A framework for neural organoids, assembloids and transplantation studies. <i>Nature</i>. 2025;639(8054):315-320. doi:<a href=\"https://doi.org/10.1038/s41586-024-08487-6\">10.1038/s41586-024-08487-6</a>","ista":"Pașca SP, Arlotta P, Bateup HS, Camp JG, Cappello S, Gage FH, Knoblich JA, Kriegstein AR, Lancaster MA, Ming GL, Novarino G, Okano H, Parmar M, Park IH, Reiner O, Song H, Studer L, Takahashi J, Temple S, Testa G, Treutlein B, Vaccarino FM, Vanderhaeghen P, Young-Pearse T. 2025. A framework for neural organoids, assembloids and transplantation studies. Nature. 639(8054), 315–320."},"volume":639,"acknowledgement":"The authors thank members of their laboratories who provided feedback on earlier versions of this manuscript, including A. Jourdon, V. Mariano, T. L. Li, N. Caporale, E. Villa and M. Sutcliffe.","abstract":[{"text":"As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. In this Perspective, we present a framework for the experimental process that encompasses ensuring the quality and integrity of human pluripotent stem cells, characterizing and manipulating neural cells in vitro, transplantation techniques and considerations for modelling human development, evolution and disease. As with all scientific endeavours, we advocate for rigorous experimental designs tailored to explicit scientific questions as well as transparent methodologies and data sharing to provide useful knowledge for current research practices and for developing regulatory standards.","lang":"eng"}],"title":"A framework for neural organoids, assembloids and transplantation studies","date_updated":"2025-03-25T08:51:53Z","quality_controlled":"1","pmid":1,"article_type":"original","issue":"8054"}