article published yes Sergei Zaǐtsev author Leonid A Sazanov author 338D39FE-F248-11E8-B48F-1D18A9856A870000-0002-0977-7989 Aleksei Koshkin author Galina Sud'Ina author Sergei Varfolomeev author An ultra-low dose (10-14 M) of opioid peptide [D-Ala2]methionine enkephalinamide (DAMEA) is found to exert an inhibitory effect on the production of reactive oxygen species (respiratory burst) in human neutrophils. The validity of this phenomenon has been verified in a series of studies that comprised 30 experiments. The inhibition has proved to be statistically significant (P&lt;0.001). The dose-response dependence of the effect (10-15-10-9 M) followed a characteristic biphasic pattern (with the maximum effect at ultra-low doses). An opioid antagonist, naloxone partially blocks the inhibitory effect, which indicates that the DAMEA action is at least partially mediated by opioid receptors. Elsevier1991 eng 0014-2956 1936255 10.1016/0014-5793(91)81109-L 291184 - 86 yes Zaǐtsev S, Sazanov LA, Koshkin A, Sud’Ina G, Varfolomeev S. Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide. <i>FEBS Letters</i>. 1991;291(1):84-86. doi:<a href="https://doi.org/10.1016/0014-5793(91)81109-L">10.1016/0014-5793(91)81109-L</a> Zaǐtsev, Sergei, Leonid A Sazanov, Aleksei Koshkin, Galina Sud’Ina, and Sergei Varfolomeev. “Respiratory Burst Inhibition in Human Neutrophils by Ultra-Low Doses of [D-Ala2] Methionine Enkephalinamide.” <i>FEBS Letters</i>. Elsevier, 1991. <a href="https://doi.org/10.1016/0014-5793(91)81109-L">https://doi.org/10.1016/0014-5793(91)81109-L</a>. S. Zaǐtsev, L.A. Sazanov, A. Koshkin, G. Sud’Ina, S. Varfolomeev, FEBS Letters 291 (1991) 84–86. Zaǐtsev, Sergei, et al. “Respiratory Burst Inhibition in Human Neutrophils by Ultra-Low Doses of [D-Ala2] Methionine Enkephalinamide.” <i>FEBS Letters</i>, vol. 291, no. 1, Elsevier, 1991, pp. 84–86, doi:<a href="https://doi.org/10.1016/0014-5793(91)81109-L">10.1016/0014-5793(91)81109-L</a>. Zaǐtsev, S., Sazanov, L. A., Koshkin, A., Sud’Ina, G., &#38; Varfolomeev, S. (1991). Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide. <i>FEBS Letters</i>. Elsevier. <a href="https://doi.org/10.1016/0014-5793(91)81109-L">https://doi.org/10.1016/0014-5793(91)81109-L</a> S. Zaǐtsev, L. A. Sazanov, A. Koshkin, G. Sud’Ina, and S. Varfolomeev, “Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide,” <i>FEBS Letters</i>, vol. 291, no. 1. Elsevier, pp. 84–86, 1991. Zaǐtsev S, Sazanov LA, Koshkin A, Sud’Ina G, Varfolomeev S. 1991. Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide. FEBS Letters. 291(1), 84–86. 19462018-12-11T11:54:51Z2022-03-07T09:49:06Z