---
_id: '1946'
abstract:
- lang: eng
  text: An ultra-low dose (10-14 M) of opioid peptide [D-Ala2]methionine enkephalinamide
    (DAMEA) is found to exert an inhibitory effect on the production of reactive oxygen
    species (respiratory burst) in human neutrophils. The validity of this phenomenon
    has been verified in a series of studies that comprised 30 experiments. The inhibition
    has proved to be statistically significant (P<0.001). The dose-response dependence
    of the effect (10-15-10-9 M) followed a characteristic biphasic pattern (with
    the maximum effect at ultra-low doses). An opioid antagonist, naloxone partially
    blocks the inhibitory effect, which indicates that the DAMEA action is at least
    partially mediated by opioid receptors.
article_processing_charge: No
author:
- first_name: Sergei
  full_name: Zaǐtsev, Sergei
  last_name: Zaǐtsev
- first_name: Leonid A
  full_name: Sazanov, Leonid A
  id: 338D39FE-F248-11E8-B48F-1D18A9856A87
  last_name: Sazanov
  orcid: 0000-0002-0977-7989
- first_name: Aleksei
  full_name: Koshkin, Aleksei
  last_name: Koshkin
- first_name: Galina
  full_name: Sud'Ina, Galina
  last_name: Sud'Ina
- first_name: Sergei
  full_name: Varfolomeev, Sergei
  last_name: Varfolomeev
citation:
  ama: Zaǐtsev S, Sazanov LA, Koshkin A, Sud’Ina G, Varfolomeev S. Respiratory burst
    inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide.
    <i>FEBS Letters</i>. 1991;291(1):84-86. doi:<a href="https://doi.org/10.1016/0014-5793(91)81109-L">10.1016/0014-5793(91)81109-L</a>
  apa: Zaǐtsev, S., Sazanov, L. A., Koshkin, A., Sud’Ina, G., &#38; Varfolomeev, S.
    (1991). Respiratory burst inhibition in human neutrophils by ultra-low doses of
    [D-Ala2] methionine enkephalinamide. <i>FEBS Letters</i>. Elsevier. <a href="https://doi.org/10.1016/0014-5793(91)81109-L">https://doi.org/10.1016/0014-5793(91)81109-L</a>
  chicago: Zaǐtsev, Sergei, Leonid A Sazanov, Aleksei Koshkin, Galina Sud’Ina, and
    Sergei Varfolomeev. “Respiratory Burst Inhibition in Human Neutrophils by Ultra-Low
    Doses of [D-Ala2] Methionine Enkephalinamide.” <i>FEBS Letters</i>. Elsevier,
    1991. <a href="https://doi.org/10.1016/0014-5793(91)81109-L">https://doi.org/10.1016/0014-5793(91)81109-L</a>.
  ieee: S. Zaǐtsev, L. A. Sazanov, A. Koshkin, G. Sud’Ina, and S. Varfolomeev, “Respiratory
    burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine
    enkephalinamide,” <i>FEBS Letters</i>, vol. 291, no. 1. Elsevier, pp. 84–86, 1991.
  ista: Zaǐtsev S, Sazanov LA, Koshkin A, Sud’Ina G, Varfolomeev S. 1991. Respiratory
    burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine
    enkephalinamide. FEBS Letters. 291(1), 84–86.
  mla: Zaǐtsev, Sergei, et al. “Respiratory Burst Inhibition in Human Neutrophils
    by Ultra-Low Doses of [D-Ala2] Methionine Enkephalinamide.” <i>FEBS Letters</i>,
    vol. 291, no. 1, Elsevier, 1991, pp. 84–86, doi:<a href="https://doi.org/10.1016/0014-5793(91)81109-L">10.1016/0014-5793(91)81109-L</a>.
  short: S. Zaǐtsev, L.A. Sazanov, A. Koshkin, G. Sud’Ina, S. Varfolomeev, FEBS Letters
    291 (1991) 84–86.
date_created: 2018-12-11T11:54:51Z
date_published: 1991-10-07T00:00:00Z
date_updated: 2022-03-07T09:49:06Z
day: '07'
doi: 10.1016/0014-5793(91)81109-L
extern: '1'
external_id:
  pmid:
  - '1936255 '
intvolume: '       291'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/001457939181109L
month: '10'
oa_version: None
page: 84 - 86
pmid: 1
publication: FEBS Letters
publication_identifier:
  issn:
  - 0014-2956
publication_status: published
publisher: Elsevier
publist_id: '5139'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2]
  methionine enkephalinamide
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 291
year: '1991'
...