{"date_published":"2024-03-04T00:00:00Z","month":"03","external_id":{"pmid":["39719709"]},"title":"Acute and circadian feedforward regulation of agouti-related peptide hunger neurons","scopus_import":"1","extern":"1","OA_type":"closed access","article_processing_charge":"No","citation":{"apa":"Douglass, A. M., Kucukdereli, H., Madara, J. C., Wang, D., Wu, C., Lowenstein, E. D., … Lowell, B. B. (2024). Acute and circadian feedforward regulation of agouti-related peptide hunger neurons. <i>Cell Metabolism</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cmet.2024.11.009\">https://doi.org/10.1016/j.cmet.2024.11.009</a>","chicago":"Douglass, Amelia M., Hakan Kucukdereli, Joseph C. Madara, Daqing Wang, Chen Wu, Elijah D. Lowenstein, Jenkang Tao, and Bradford B. Lowell. “Acute and Circadian Feedforward Regulation of Agouti-Related Peptide Hunger Neurons.” <i>Cell Metabolism</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cmet.2024.11.009\">https://doi.org/10.1016/j.cmet.2024.11.009</a>.","mla":"Douglass, Amelia M., et al. “Acute and Circadian Feedforward Regulation of Agouti-Related Peptide Hunger Neurons.” <i>Cell Metabolism</i>, vol. 37, no. 3, Elsevier, 2024, p. 708–722.e5, doi:<a href=\"https://doi.org/10.1016/j.cmet.2024.11.009\">10.1016/j.cmet.2024.11.009</a>.","ama":"Douglass AM, Kucukdereli H, Madara JC, et al. Acute and circadian feedforward regulation of agouti-related peptide hunger neurons. <i>Cell Metabolism</i>. 2024;37(3):708-722.e5. doi:<a href=\"https://doi.org/10.1016/j.cmet.2024.11.009\">10.1016/j.cmet.2024.11.009</a>","short":"A.M. Douglass, H. Kucukdereli, J.C. Madara, D. Wang, C. Wu, E.D. Lowenstein, J. Tao, B.B. Lowell, Cell Metabolism 37 (2024) 708–722.e5.","ieee":"A. M. Douglass <i>et al.</i>, “Acute and circadian feedforward regulation of agouti-related peptide hunger neurons,” <i>Cell Metabolism</i>, vol. 37, no. 3. Elsevier, p. 708–722.e5, 2024.","ista":"Douglass AM, Kucukdereli H, Madara JC, Wang D, Wu C, Lowenstein ED, Tao J, Lowell BB. 2024. Acute and circadian feedforward regulation of agouti-related peptide hunger neurons. Cell Metabolism. 37(3), 708–722.e5."},"publisher":"Elsevier","volume":37,"issue":"3","type":"journal_article","date_created":"2025-04-03T12:27:39Z","abstract":[{"lang":"eng","text":"When food is freely available, eating occurs without energy deficit. While agouti-related peptide (AgRP) neurons are likely involved, their activation is thought to require negative energy balance. To investigate this, we implemented long-term, continuous in vivo fiber-photometry recordings in mice. We discovered new forms of AgRP neuron regulation, including fast pre-ingestive decreases in activity and unexpectedly rapid activation by fasting. Furthermore, AgRP neuron activity has a circadian rhythm that peaks concurrent with the daily feeding onset. Importantly, this rhythm persists when nutrition is provided via constant-rate gastric infusions. Hence, it is not secondary to a circadian feeding rhythm. The AgRP neuron rhythm is driven by the circadian clock, the suprachiasmatic nucleus (SCN), as SCN ablation abolishes the circadian rhythm in AgRP neuron activity and feeding. The SCN activates AgRP neurons via excitatory afferents from thyrotrophin-releasing hormone-expressing neurons in the dorsomedial hypothalamus (DMHTrh neurons) to drive daily feeding rhythms."}],"year":"2024","status":"public","_id":"19470","publication_status":"published","oa_version":"None","pmid":1,"publication":"Cell Metabolism","doi":"10.1016/j.cmet.2024.11.009","date_updated":"2025-07-10T11:51:40Z","page":"708-722.e5","article_type":"original","publication_identifier":{"issn":["1550-4131"]},"day":"04","language":[{"iso":"eng"}],"quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Douglass","first_name":"Amelia May Barnett","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","orcid":"0000-0001-5398-6473","full_name":"Douglass, Amelia May Barnett"},{"last_name":"Kucukdereli","first_name":"Hakan","full_name":"Kucukdereli, Hakan"},{"full_name":"Madara, Joseph C.","last_name":"Madara","first_name":"Joseph C."},{"first_name":"Daqing","last_name":"Wang","full_name":"Wang, Daqing"},{"full_name":"Wu, Chen","last_name":"Wu","first_name":"Chen"},{"last_name":"Lowenstein","first_name":"Elijah D.","full_name":"Lowenstein, Elijah D."},{"full_name":"Tao, Jenkang","last_name":"Tao","first_name":"Jenkang"},{"first_name":"Bradford B.","last_name":"Lowell","full_name":"Lowell, Bradford B."}],"intvolume":"        37"}