---
res:
  bibo_abstract:
  - The forebrain hemispheres are predominantly separated during embryogenesis by
    the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a
    continuous substrate between the hemispheres for midline crossing of the corpus
    callosum (CC) and hippocampal commissure (HC). Deleted in colorectal carcinoma
    (DCC) and netrin 1 (NTN1) are molecules that have an evolutionarily conserved
    function in commissural axon guidance. The CC and HC are absent in <jats:italic>Dcc</jats:italic>
    and <jats:italic>Ntn1</jats:italic> knockout mice, while other commissures are
    only partially affected, suggesting an additional aetiology in forebrain commissure
    formation. Here, we find that these molecules play a critical role in regulating
    astroglial development and IHF remodelling during CC and HC formation. Human subjects
    with <jats:italic>DCC</jats:italic> mutations display disrupted IHF remodelling
    associated with CC and HC malformations. Thus, axon guidance molecules such as
    DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures
    prior to their role in regulating axonal growth and guidance across it.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Morcom, Laura
      foaf_surname: Morcom
  - foaf_Person:
      foaf_givenName: Ilan
      foaf_name: Gobius, Ilan
      foaf_surname: Gobius
  - foaf_Person:
      foaf_givenName: Ashley PL
      foaf_name: Marsh, Ashley PL
      foaf_surname: Marsh
  - foaf_Person:
      foaf_givenName: Rodrigo
      foaf_name: Suárez, Rodrigo
      foaf_surname: Suárez
  - foaf_Person:
      foaf_givenName: Jonathan WC
      foaf_name: Lim, Jonathan WC
      foaf_surname: Lim
  - foaf_Person:
      foaf_givenName: Caitlin
      foaf_name: Bridges, Caitlin
      foaf_surname: Bridges
  - foaf_Person:
      foaf_givenName: Yunan
      foaf_name: Ye, Yunan
      foaf_surname: Ye
  - foaf_Person:
      foaf_givenName: Laura R
      foaf_name: Fenlon, Laura R
      foaf_surname: Fenlon
  - foaf_Person:
      foaf_givenName: Yvrick
      foaf_name: Zagar, Yvrick
      foaf_surname: Zagar
  - foaf_Person:
      foaf_givenName: Amelia May Barnett
      foaf_name: Douglass, Amelia May Barnett
      foaf_surname: Douglass
      foaf_workInfoHomepage: http://www.librecat.org/personId=de5f6fda-80fb-11ef-996f-a8c4ecd8e289
    orcid: 0000-0001-5398-6473
  - foaf_Person:
      foaf_givenName: Amber-Lee S
      foaf_name: Donahoo, Amber-Lee S
      foaf_surname: Donahoo
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Fothergill, Thomas
      foaf_surname: Fothergill
  - foaf_Person:
      foaf_givenName: Samreen
      foaf_name: Shaikh, Samreen
      foaf_surname: Shaikh
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Kozulin, Peter
      foaf_surname: Kozulin
  - foaf_Person:
      foaf_givenName: Timothy J
      foaf_name: Edwards, Timothy J
      foaf_surname: Edwards
  - foaf_Person:
      foaf_givenName: Helen M
      foaf_name: Cooper, Helen M
      foaf_surname: Cooper
  - foaf_Person:
      foaf_givenName: Elliott H
      foaf_name: Sherr, Elliott H
      foaf_surname: Sherr
  - foaf_Person:
      foaf_givenName: Alain
      foaf_name: Chédotal, Alain
      foaf_surname: Chédotal
  - foaf_Person:
      foaf_givenName: Richard J
      foaf_name: Leventer, Richard J
      foaf_surname: Leventer
  - foaf_Person:
      foaf_givenName: Paul J
      foaf_name: Lockhart, Paul J
      foaf_surname: Lockhart
  - foaf_Person:
      foaf_givenName: Linda J
      foaf_name: Richards, Linda J
      foaf_surname: Richards
  bibo_doi: 10.7554/elife.61769
  bibo_volume: 10
  dct_date: 2021^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2050-084X
  dct_language: eng
  dct_publisher: eLife Sciences Publications@
  dct_title: DCC regulates astroglial development essential for telencephalic morphogenesis
    and corpus callosum formation@
  fabio_hasPubmedId: '33871356'
...