---
res:
  bibo_abstract:
  - Leptin informs the brain about sufficiency of fuel stores. When insufficient,
    leptin levels fall, triggering compensatory increases in appetite. Falling leptin
    is first sensed by hypothalamic neurons, which then initiate adaptive responses.
    With regard to hunger, it is thought that leptin-sensing neurons work entirely
    via circuits within the central nervous system (CNS). Very unexpectedly, however,
    we now show this is not the case. Instead, stimulation of hunger requires an intervening
    endocrine step, namely activation of the hypothalamic–pituitary–adrenocortical
    (HPA) axis. Increased corticosterone then activates AgRP neurons to fully increase
    hunger. Importantly, this is true for 2 forms of low leptin-induced hunger, fasting
    and poorly controlled type 1 diabetes. Hypoglycemia, which also stimulates hunger
    by activating CNS neurons, albeit independently of leptin, similarly recruits
    and requires this pathway by which HPA axis activity stimulates AgRP neurons.
    Thus, HPA axis regulation of AgRP neurons is a previously underappreciated step
    in homeostatic regulation of hunger.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Rachel J.
      foaf_name: Perry, Rachel J.
      foaf_surname: Perry
  - foaf_Person:
      foaf_givenName: Jon M.
      foaf_name: Resch, Jon M.
      foaf_surname: Resch
  - foaf_Person:
      foaf_givenName: Amelia May Barnett
      foaf_name: Douglass, Amelia May Barnett
      foaf_surname: Douglass
      foaf_workInfoHomepage: http://www.librecat.org/personId=de5f6fda-80fb-11ef-996f-a8c4ecd8e289
    orcid: 0000-0001-5398-6473
  - foaf_Person:
      foaf_givenName: Joseph C.
      foaf_name: Madara, Joseph C.
      foaf_surname: Madara
  - foaf_Person:
      foaf_givenName: Aviva
      foaf_name: Rabin-Court, Aviva
      foaf_surname: Rabin-Court
  - foaf_Person:
      foaf_givenName: Hakan
      foaf_name: Kucukdereli, Hakan
      foaf_surname: Kucukdereli
  - foaf_Person:
      foaf_givenName: Chen
      foaf_name: Wu, Chen
      foaf_surname: Wu
  - foaf_Person:
      foaf_givenName: Joongyu D.
      foaf_name: Song, Joongyu D.
      foaf_surname: Song
  - foaf_Person:
      foaf_givenName: Bradford B.
      foaf_name: Lowell, Bradford B.
      foaf_surname: Lowell
  - foaf_Person:
      foaf_givenName: Gerald I.
      foaf_name: Shulman, Gerald I.
      foaf_surname: Shulman
  bibo_doi: 10.1073/pnas.1901795116
  bibo_issue: '27'
  bibo_volume: 116
  dct_date: 2019^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Leptin’s hunger-suppressing effects are mediated by the hypothalamic–pituitary–adrenocortical
    axis in rodents@
  fabio_hasPubmedId: '31213533'
...