---
res:
  bibo_abstract:
  - A dynamic interplay between fast synaptic signals and slower neuromodulatory signals
    controls the excitatory/inhibitory (E/I) balance within neuronal circuits. The
    mechanisms by which neuropeptide signaling is regulated to maintain E/I balance
    remain uncertain. We designed a genetic screen to isolate genes involved in the
    peptidergic maintenance of the E/I balance in the C. elegans motor circuit. This
    screen identified the C. elegans orthologs of the presynaptic phosphoprotein synapsin
    (snn-1) and the protein phosphatase 1 (PP1) regulatory subunit PHACTR1 (phac-1).
    We demonstrate that both phac-1 and snn-1 alter the motor behavior of C. elegans,
    and genetic interactions suggest that SNN-1 contributes to PP1-PHAC-1 holoenzyme
    signaling. De novo variants of human PHACTR1, associated with early-onset epilepsies
    [developmental and epileptic encephalopathy 70 (DEE70)], when expressed in C.
    elegans resulted in constitutive PP1-PHAC-1 holoenzyme activity. Unregulated PP1-PHAC-1
    signaling alters the synapsin and actin cytoskeleton and increases neuropeptide
    release by cholinergic motor neurons, which secondarily affects the presynaptic
    vesicle cycle. Together, these results clarify the dominant mechanisms of action
    of the DEE70 alleles and suggest that altered neuropeptide release may alter E/I
    balance in DEE70.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Aikaterini
      foaf_name: Stratigi, Aikaterini
      foaf_surname: Stratigi
  - foaf_Person:
      foaf_givenName: Miguel
      foaf_name: Soler-García, Miguel
      foaf_surname: Soler-García
  - foaf_Person:
      foaf_givenName: Mia
      foaf_name: Krout, Mia
      foaf_surname: Krout
  - foaf_Person:
      foaf_givenName: Shikha
      foaf_name: Shukla, Shikha
      foaf_surname: Shukla
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: De Bono, Mario
      foaf_surname: De Bono
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8347-0443
  - foaf_Person:
      foaf_givenName: Janet E.
      foaf_name: Richmond, Janet E.
      foaf_surname: Richmond
  - foaf_Person:
      foaf_givenName: Patrick
      foaf_name: Laurent, Patrick
      foaf_surname: Laurent
  bibo_doi: 10.1523/JNEUROSCI.1767-23.2024
  bibo_issue: '13'
  bibo_volume: 45
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001460952700001
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  - http://id.crossref.org/issn/1529-2401
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Neuroendocrine control of synaptic transmission by PHAC-1 in C. elegans@
  fabio_hasPubmedId: '39919830'
...