---
res:
  bibo_abstract:
  - Vertebrates exhibit a wide range of motor behaviors, ranging from swimming to
    complex limb-based movements. Here we take advantage of frog metamorphosis, which
    captures a swim-to-limb-based movement transformation during the development of
    a single organism, to explore changes in the underlying spinal circuits. We find
    that the tadpole spinal cord contains small and largely homogeneous populations
    of motor neurons (MNs) and V1 interneurons (V1s) at early escape swimming stages.
    These neuronal populations only modestly increase in number and subtype heterogeneity
    with the emergence of free swimming. In contrast, during frog metamorphosis and
    the emergence of limb movement, there is a dramatic expansion of MN and V1 interneuron
    number and transcriptional heterogeneity, culminating in cohorts of neurons that
    exhibit striking molecular similarity to mammalian motor circuits. CRISPR/Cas9-mediated
    gene disruption of the limb MN and V1 determinants FoxP1 and Engrailed-1, respectively,
    results in severe but selective deficits in tail and limb function. Our work thus
    demonstrates that neural diversity scales exponentially with increasing behavioral
    complexity and illustrates striking evolutionary conservation in the molecular
    organization and function of motor circuits across species.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Vijatovic, David
      foaf_surname: Vijatovic
      foaf_workInfoHomepage: http://www.librecat.org/personId=cf391e77-ec3c-11ea-a124-d69323410b58
  - foaf_Person:
      foaf_givenName: 'Florina Alexandra '
      foaf_name: 'Toma, Florina Alexandra '
      foaf_surname: Toma
      foaf_workInfoHomepage: http://www.librecat.org/personId=2f73f876-f128-11eb-9611-b96b5a30cb0e
  - foaf_Person:
      foaf_givenName: Zoe P
      foaf_name: Harrington, Zoe P
      foaf_surname: Harrington
      foaf_workInfoHomepage: http://www.librecat.org/personId=a8144562-32c9-11ee-b5ce-d9800628bda2
    orcid: 0009-0008-0158-4032
  - foaf_Person:
      foaf_givenName: Christoph M
      foaf_name: Sommer, Christoph M
      foaf_surname: Sommer
      foaf_workInfoHomepage: http://www.librecat.org/personId=4DF26D8C-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1216-9105
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Hauschild, Robert
      foaf_surname: Hauschild
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E01D6B4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9843-3522
  - foaf_Person:
      foaf_givenName: Alexandra J.
      foaf_name: Trevisan, Alexandra J.
      foaf_surname: Trevisan
  - foaf_Person:
      foaf_givenName: Phillip
      foaf_name: Chapman, Phillip
      foaf_surname: Chapman
  - foaf_Person:
      foaf_givenName: Mara
      foaf_name: Julseth, Mara
      foaf_surname: Julseth
      foaf_workInfoHomepage: http://www.librecat.org/personId=1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
  - foaf_Person:
      foaf_givenName: Susan
      foaf_name: Brenner-Morton, Susan
      foaf_surname: Brenner-Morton
  - foaf_Person:
      foaf_givenName: Mariano I.
      foaf_name: Gabitto, Mariano I.
      foaf_surname: Gabitto
  - foaf_Person:
      foaf_givenName: Jeremy S.
      foaf_name: Dasen, Jeremy S.
      foaf_surname: Dasen
  - foaf_Person:
      foaf_givenName: Jay B.
      foaf_name: Bikoff, Jay B.
      foaf_surname: Bikoff
  - foaf_Person:
      foaf_givenName: Lora Beatrice Jaeger
      foaf_name: Sweeney, Lora Beatrice Jaeger
      foaf_surname: Sweeney
      foaf_workInfoHomepage: http://www.librecat.org/personId=56BE8254-C4F0-11E9-8E45-0B23E6697425
    orcid: 0000-0001-9242-5601
  bibo_doi: 10.1101/2024.09.20.614050
  dct_date: 2024^xs_gYear
  dct_language: eng
  dct_title: Spinal neuron diversity scales exponentially with swim-to-limb transformation
    during frog metamorphosis@
...