{"extern":"1","main_file_link":[{"open_access":"1","url":"https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/0014-5793%2894%2901109-5"}],"status":"public","abstract":[{"lang":"eng","text":"The respiratory burst induced by phorbol myristate acetate in mouse macrophages was inhibited by ultra-low doses (10-15 -10-13 M) of an opioid peptide [d-Ala2] methionine enkephalinamide. The effect disappeared at concentrations above and below this range. The inhibition approached 50% and was statistically significant (P &lt; 0.001). Increasing the time of the opioid incubation with cells brought about a shift in the maximal effect to lower concentrations of the opioid (from 10-13 to 5 · 10-15 M) and led to a decrease in the value of the effect, fully in accord with the previously proposed adaptation mechanism of the action of ultra-low doses."}],"intvolume":"       355","date_updated":"2022-06-09T12:58:57Z","quality_controlled":"1","day":"28","external_id":{"pmid":["7982481"]},"article_type":"original","volume":355,"pmid":1,"publist_id":"5133","author":[{"full_name":"Efanov, Alexander","first_name":"Alexander","last_name":"Efanov"},{"last_name":"Koshkin","first_name":"Aleksei","full_name":"Koshkin, Aleksei"},{"full_name":"Sazanov, Leonid A","orcid":"0000-0002-0977-7989","first_name":"Leonid A","last_name":"Sazanov","id":"338D39FE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Borodulina","full_name":"Borodulina, O I","first_name":"O I"},{"first_name":"Sergei","full_name":"Varfolomeev, Sergei","last_name":"Varfolomeev"},{"full_name":"Zaǐtsev, Sergei","first_name":"Sergei","last_name":"Zaǐtsev"}],"language":[{"iso":"eng"}],"page":"114 - 116","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_created":"2018-12-11T11:54:53Z","publication":"FEBS Letters","article_processing_charge":"No","date_published":"1994-11-28T00:00:00Z","year":"1994","title":"Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism","issue":"2","month":"11","_id":"1953","publication_identifier":{"issn":["0014-5793"]},"doi":"10.1016/0014-5793(94)01109-5","type":"journal_article","citation":{"apa":"Efanov, A., Koshkin, A., Sazanov, L. A., Borodulina, O. I., Varfolomeev, S., &#38; Zaǐtsev, S. (1994). Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. <i>FEBS Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">https://doi.org/10.1016/0014-5793(94)01109-5</a>","short":"A. Efanov, A. Koshkin, L.A. Sazanov, O.I. Borodulina, S. Varfolomeev, S. Zaǐtsev, FEBS Letters 355 (1994) 114–116.","ieee":"A. Efanov, A. Koshkin, L. A. Sazanov, O. I. Borodulina, S. Varfolomeev, and S. Zaǐtsev, “Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism,” <i>FEBS Letters</i>, vol. 355, no. 2. Elsevier, pp. 114–116, 1994.","chicago":"Efanov, Alexander, Aleksei Koshkin, Leonid A Sazanov, O I Borodulina, Sergei Varfolomeev, and Sergei Zaǐtsev. “Inhibition of the Respiratory Burst in Mouse Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation Mechanism.” <i>FEBS Letters</i>. Elsevier, 1994. <a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">https://doi.org/10.1016/0014-5793(94)01109-5</a>.","mla":"Efanov, Alexander, et al. “Inhibition of the Respiratory Burst in Mouse Macrophages by Ultra-Low Doses of an Opioid Peptide Is Consistent with a Possible Adaptation Mechanism.” <i>FEBS Letters</i>, vol. 355, no. 2, Elsevier, 1994, pp. 114–16, doi:<a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">10.1016/0014-5793(94)01109-5</a>.","ama":"Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. <i>FEBS Letters</i>. 1994;355(2):114-116. doi:<a href=\"https://doi.org/10.1016/0014-5793(94)01109-5\">10.1016/0014-5793(94)01109-5</a>","ista":"Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. 1994. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. 355(2), 114–116."},"oa_version":"Published Version","publisher":"Elsevier","oa":1,"publication_status":"published"}