---
res:
  bibo_abstract:
  - Active regulation of gene expression, orchestrated by complex interactions of
    activators and repressors at promoters, controls the fate of organisms. In contrast,
    basal expression at uninduced promoters is considered to be a dynamically inert
    mode of nonfunctional “promoter leakiness,” merely a byproduct of transcriptional
    regulation. Here, we investigate the basal expression mode of the mar operon,
    the main regulator of intrinsic multiple antibiotic resistance in Escherichia
    coli, and link its dynamic properties to the noncanonical, yet highly conserved
    start codon of marR across Enterobacteriaceae. Real-time, single-cell measurements
    across tens of generations reveal that basal expression consists of rare stochastic
    gene expression pulses, which maximize variability in wildtype and, surprisingly,
    transiently accelerate cellular elongation rates. Competition experiments show
    that basal expression confers fitness advantages to wildtype across several transitions
    between exponential and stationary growth by shortening lag times. The dynamically
    rich basal expression of the mar operon has likely been evolutionarily maintained
    for its role in growth homeostasis of Enterobacteria within the gut environment,
    thereby allowing other ancillary gene regulatory roles to evolve, e.g., control
    of costly-to-induce multidrug efflux pumps. Understanding the complex selection
    forces governing genetic systems involved in intrinsic multidrug resistance is
    crucial for effective public health measures.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Kirti
      foaf_name: Jain, Kirti
      foaf_surname: Jain
      foaf_workInfoHomepage: http://www.librecat.org/personId=330F0278-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-3809-0449
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Hauschild, Robert
      foaf_surname: Hauschild
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E01D6B4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9843-3522
  - foaf_Person:
      foaf_givenName: Olga
      foaf_name: Bochkareva, Olga
      foaf_surname: Bochkareva
      foaf_workInfoHomepage: http://www.librecat.org/personId=C4558D3C-6102-11E9-A62E-F418E6697425
    orcid: 0000-0003-1006-6639
  - foaf_Person:
      foaf_givenName: Roderich
      foaf_name: Römhild, Roderich
      foaf_surname: Römhild
      foaf_workInfoHomepage: http://www.librecat.org/personId=68E56E44-62B0-11EA-B963-444F3DDC885E
    orcid: 0000-0001-9480-5261
  - foaf_Person:
      foaf_givenName: Gašper
      foaf_name: Tkačik, Gašper
      foaf_surname: Tkačik
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D494DCA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6699-1455
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.1073/pnas.2413709122
  bibo_issue: '15'
  bibo_volume: 122
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001471235200001
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Pulsatile basal gene expression as a fitness determinant in bacteria@
  fabio_hasPubmedId: '40193613'
...