---
res:
  bibo_abstract:
  - Radial glial progenitors (RGPs) generate all projection neurons (PNs) in the cerebral
    cortex through incompletely understood processes. Herein, we combine Mosaic Analysis
    with Double Markers (MADM)-based clonal analysis at embryonic days 12.5 and 13.5
    with early postnatal callosal tracing to reveal a lineage progression that challenges
    the inside-outside model of cortical development and the conventional view of
    an invariable sequence of asymmetric neurogenic divisions. Our data demonstrate
    that early multipotent RGPs generate all extra-telencephalic (ET) and intra-telencephalic
    (IT) PNs across all layers through parallel sublineages and the random specification,
    during the earliest neurogenic divisions, of fate-restricted daughter RGPs. While
    the neuronal production of the parental multipotent RGPs consists of small ET-PN
    or IT-PN outputs, fate-restricted RGPs produce larger translaminar outputs spanning
    deep and upper layers of only IT-PNs, the predominant mammalian PN subtype. We
    further show that the emergence of IT-PN fate-restricted RGPs also leads to quantitatively
    and temporally stereotyped neurogenesis population-wise.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: I
      foaf_name: Varela-Martínez, I
      foaf_surname: Varela-Martínez
  - foaf_Person:
      foaf_givenName: Ana
      foaf_name: Villalba Requena, Ana
      foaf_surname: Villalba Requena
      foaf_workInfoHomepage: http://www.librecat.org/personId=68cb85a0-39f7-11eb-9559-9aaab4f6a247
    orcid: 0000-0002-5615-5277
  - foaf_Person:
      foaf_givenName: J.
      foaf_name: Garcia-Marqués, J.
      foaf_surname: Garcia-Marqués
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  - foaf_Person:
      foaf_givenName: M.
      foaf_name: Nieto, M.
      foaf_surname: Nieto
  bibo_doi: 10.1101/2025.05.07.652665
  dct_date: 2025^xs_gYear
  dct_language: eng
  dct_title: Early emergence of projection-subtype fate-restricted radial glial progenitors
    orchestrates neocortical neurogenesis@
...