article published Martin Loose author 462D4284-F248-11E8-B48F-1D18A9856A870000-0001-7309-9724 Elisabeth Fischer Friedrich author Jonas Ries author Karsten Kruse author Petra Schwille author In the bacterium Escherichia coli, the Min proteins oscillate between the cell poles to select the cell center as division site. This dynamic pattern has been proposed to arise by self-organization of these proteins, and several models have suggested a reaction-diffusion type mechanism. Here, we found that the Min proteins spontaneously formed planar surface waves on a flat membrane in vitro. The formation and maintenance of these patterns, which extended for hundreds of micrometers, required adenosine 5′-triphosphate (ATP), and they persisted for hours. We present a reaction-diffusion model of the MinD and MinE dynamics that accounts for our experimental observations and also captures the in vivo oscillations. American Association for the Advancement of Science2008 10.1126/science.1154413 3205877789 - 792 yes Loose M, Fischer Friedrich E, Ries J, Kruse K, Schwille P. Spatial regulators for bacterial cell division self-organize into surface waves in vitro. <i>Science</i>. 2008;320(5877):789-792. doi:<a href="https://doi.org/10.1126/science.1154413">10.1126/science.1154413</a> Loose M, Fischer Friedrich E, Ries J, Kruse K, Schwille P. 2008. Spatial regulators for bacterial cell division self-organize into surface waves in vitro. Science. 320(5877), 789–792. M. Loose, E. Fischer Friedrich, J. Ries, K. Kruse, and P. Schwille, “Spatial regulators for bacterial cell division self-organize into surface waves in vitro,” <i>Science</i>, vol. 320, no. 5877. American Association for the Advancement of Science, pp. 789–792, 2008. M. Loose, E. Fischer Friedrich, J. Ries, K. Kruse, P. Schwille, Science 320 (2008) 789–792. Loose, Martin, et al. “Spatial Regulators for Bacterial Cell Division Self-Organize into Surface Waves in Vitro.” <i>Science</i>, vol. 320, no. 5877, American Association for the Advancement of Science, 2008, pp. 789–92, doi:<a href="https://doi.org/10.1126/science.1154413">10.1126/science.1154413</a>. Loose, Martin, Elisabeth Fischer Friedrich, Jonas Ries, Karsten Kruse, and Petra Schwille. “Spatial Regulators for Bacterial Cell Division Self-Organize into Surface Waves in Vitro.” <i>Science</i>. American Association for the Advancement of Science, 2008. <a href="https://doi.org/10.1126/science.1154413">https://doi.org/10.1126/science.1154413</a>. Loose, M., Fischer Friedrich, E., Ries, J., Kruse, K., &#38; Schwille, P. (2008). Spatial regulators for bacterial cell division self-organize into surface waves in vitro. <i>Science</i>. American Association for the Advancement of Science. <a href="https://doi.org/10.1126/science.1154413">https://doi.org/10.1126/science.1154413</a> 19822018-12-11T11:55:02Z2021-01-12T06:54:30Z