---
res:
  bibo_abstract:
  - 'Background: Norepinephrine (NE) signaling has a key role in white adipose tissue
    (WAT) functions, including lipolysis, free fatty acid liberation and, under certain
    conditions, conversion of white into brite (brown-in-white) adipocytes. However,
    acute effects of NE stimulation have not been described at the transcriptional
    network level. Results: We used RNA-seq to uncover a broad transcriptional response.
    The inference of protein-protein and protein-DNA interaction networks allowed
    us to identify a set of immediate-early genes (IEGs) with high betweenness, validating
    our approach and suggesting a hierarchical control of transcriptional regulation.
    In addition, we identified a transcriptional regulatory network with IEGs as master
    regulators, including HSF1 and NFIL3 as novel NE-induced IEG candidates. Moreover,
    a functional enrichment analysis and gene clustering into functional modules suggest
    a crosstalk between metabolic, signaling, and immune responses. Conclusions: Altogether,
    our network biology approach explores for the first time the immediate-early systems
    level response of human adipocytes to acute sympathetic activation, thereby providing
    a first network basis of early cell fate programs and crosstalks between metabolic
    and transcriptional networks required for proper WAT function.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Juan
      foaf_name: Higareda Almaraz, Juan
      foaf_surname: Higareda Almaraz
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Karbiener, Michael
      foaf_surname: Karbiener
  - foaf_Person:
      foaf_givenName: Maude
      foaf_name: Giroud, Maude
      foaf_surname: Giroud
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Pauler, Florian
      foaf_surname: Pauler
      foaf_workInfoHomepage: http://www.librecat.org/personId=48EA0138-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7462-0048
  - foaf_Person:
      foaf_givenName: Teresa
      foaf_name: Gerhalter, Teresa
      foaf_surname: Gerhalter
  - foaf_Person:
      foaf_givenName: Stephan
      foaf_name: Herzig, Stephan
      foaf_surname: Herzig
  - foaf_Person:
      foaf_givenName: Marcel
      foaf_name: Scheideler, Marcel
      foaf_surname: Scheideler
  bibo_doi: 10.1186/s12864-018-5173-0
  bibo_issue: '1'
  bibo_volume: 19
  dct_date: 2018^xs_gYear
  dct_identifier:
  - UT:000450976700002
  dct_isPartOf:
  - http://id.crossref.org/issn/1471-2164
  dct_language: eng
  dct_publisher: BioMed Central@
  dct_title: Norepinephrine triggers an immediate-early regulatory network response
    in primary human white adipocytes@
...