---
res:
  bibo_abstract:
  - "Immune responses depend on the coordinated and efficient migration of leukocytes.
    These\r\ncells, which are embedded and tightly confined within tissues, must navigate
    and traverse\r\ndiverse and complex three-dimensional environments. Leukocytes
    adapt their locomotory\r\nbehavior to the mechanical, geometrical, and biochemical
    characteristics of their\r\nsurroundings. In low-density environments, where the
    pore size of the interstitial matrix\r\nallows free passage, these cells position
    the nucleus directly behind the lamellipodium, the\r\nprotrusive actin structure
    that forms the leading front of the cell. In this configuration, they\r\nuse the
    nucleus as a gauge to identify the path of least resistance.\r\nHere, we show
    that in high-density environments, where the pore size precludes free passage\r\nof
    the cell body, leukocytes reposition the microtubule-organizing center (MTOC)
    and\r\nassociated organelles in front of the nucleus. In this configuration, they
    use actin structures\r\nprotruding orthogonally to the direction of migration
    in order to open a path for the cell body.\r\nWe identify two distinct actin populations
    that serve this purpose at different subcellular\r\nlocalizations. At the leading
    edge, local indentation of the plasma membrane leads to\r\nrecruitment of the
    Wiskott-Aldrich syndrome protein (WASp), which, via Arp2/3, results in\r\nthe
    formation of individual actin foci. At the cell body, actin polymerization is
    triggered by\r\nDOCK8, a Cdc42 exchange factor, resulting in the formation of
    a central actin pool.\r\nWe demonstrate that the central and peripheral actin
    pools are functionally communicating\r\nand that depletion of the central actin
    pool leads to increased actin accumulation at the cell\r\nfront, resulting in
    excessive extension of the leading edge.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Patricia
      foaf_name: Dos Reis Rodrigues, Patricia
      foaf_surname: Dos Reis Rodrigues
      foaf_workInfoHomepage: http://www.librecat.org/personId=26E95904-5160-11E9-9C0B-C5B0DC97E90F
    orcid: 0000-0003-1681-508X
  bibo_doi: 10.15479/AT-ISTA-20149
  dct_date: 2025^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2663-337X
  dct_language: eng
  dct_publisher: Institute of Science and Technology Austria@
  dct_title: Coordination of protrusive forces in immune cell migration @
...