{"oa_version":"None","type":"journal_article","author":[{"full_name":"Desrivières, Sylvane","last_name":"Desrivières","first_name":"Sylvane"},{"last_name":"Miller","first_name":"Abigail","full_name":"Miller, Abigail"},{"first_name":"Carina M.","last_name":"Mathey","full_name":"Mathey, Carina M."},{"full_name":"Yu, Xinyang","last_name":"Yu","first_name":"Xinyang"},{"full_name":"Chen, Di","first_name":"Di","last_name":"Chen"},{"last_name":"Agunbiade","first_name":"Kofoworola","full_name":"Agunbiade, Kofoworola"},{"last_name":"Heilmann-Heimbach","first_name":"Stefanie","full_name":"Heilmann-Heimbach, Stefanie"},{"first_name":"Andreas J.","last_name":"Forstner","full_name":"Forstner, Andreas J."},{"full_name":"Schumann, Gunter","first_name":"Gunter","last_name":"Schumann"},{"last_name":"Hoffmann","first_name":"Per","full_name":"Hoffmann, Per"},{"full_name":"Nöthen, Markus M.","last_name":"Nöthen","first_name":"Markus M."},{"full_name":"Ogoh, George","last_name":"Ogoh","first_name":"George"},{"last_name":"Stahl","first_name":"Bernd","full_name":"Stahl, Bernd"},{"first_name":"Allan H.","last_name":"Young","full_name":"Young, Allan H."},{"first_name":"Nicholas","last_name":"Clinton","full_name":"Clinton, Nicholas"},{"full_name":"Thompson, Paul","last_name":"Thompson","first_name":"Paul"},{"last_name":"Schwalber","first_name":"Ameli","full_name":"Schwalber, Ameli"},{"first_name":"Jingyu","last_name":"Liu","full_name":"Liu, Jingyu"},{"first_name":"Vince","last_name":"Calhoun","full_name":"Calhoun, Vince"},{"last_name":"Chang","first_name":"Xiao","full_name":"Chang, Xiao"},{"full_name":"Xia, Yunman","first_name":"Yunman","last_name":"Xia"},{"last_name":"Gong","first_name":"Yanting","full_name":"Gong, Yanting"},{"full_name":"Jia, Tianye","first_name":"Tianye","last_name":"Jia"},{"last_name":"Renner","first_name":"Paul","full_name":"Renner, Paul"},{"full_name":"Hese, Sören","last_name":"Hese","first_name":"Sören"},{"last_name":"Giner","first_name":"Arantxa","full_name":"Giner, Arantxa"},{"full_name":"Sanchez, Mavi","first_name":"Mavi","last_name":"Sanchez"},{"first_name":"Elena","last_name":"Alvarez","full_name":"Alvarez, Elena"},{"full_name":"Spanlang, Bernhard","last_name":"Spanlang","first_name":"Bernhard"},{"full_name":"Pearmund, Charlie","first_name":"Charlie","last_name":"Pearmund"},{"full_name":"Athanasiadis, Anastasios Polykarpos","first_name":"Anastasios Polykarpos","last_name":"Athanasiadis"},{"first_name":"Lisa","last_name":"Otten","full_name":"Otten, Lisa"},{"first_name":"Séverine","last_name":"Pitel","full_name":"Pitel, Séverine"},{"full_name":"Petkoski, Spase","first_name":"Spase","last_name":"Petkoski"},{"last_name":"Jirsa","first_name":"Viktor","full_name":"Jirsa, Viktor"},{"full_name":"Schmitt, Karen","last_name":"Schmitt","first_name":"Karen"},{"full_name":"Wilbertz, Johannes","last_name":"Wilbertz","first_name":"Johannes"},{"last_name":"Patraskaki","first_name":"Myrto","full_name":"Patraskaki, Myrto"},{"full_name":"Sommer, Peter","last_name":"Sommer","first_name":"Peter"},{"full_name":"Claus, Isabelle","last_name":"Claus","first_name":"Isabelle"},{"last_name":"Pastor","first_name":"Alvaro","full_name":"Pastor, Alvaro"},{"last_name":"Gallego","first_name":"Jaime","full_name":"Gallego, Jaime"},{"full_name":"Orosa, Francisco Eiroa","last_name":"Orosa","first_name":"Francisco Eiroa"},{"first_name":"Guillem Feixas","last_name":"Viapiana","full_name":"Viapiana, Guillem Feixas"},{"full_name":"Slater, Mel","first_name":"Mel","last_name":"Slater"},{"full_name":"Marr, Lena","id":"4406F586-F248-11E8-B48F-1D18A9856A87","last_name":"Marr","first_name":"Lena"},{"last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia","orcid":"0000-0002-7673-7178"},{"full_name":"Marquand, Andre","last_name":"Marquand","first_name":"Andre"},{"full_name":"Böttger, Sarah Jane","first_name":"Sarah Jane","last_name":"Böttger"},{"last_name":"Tschorn","first_name":"Mira","full_name":"Tschorn, Mira"},{"last_name":"Rapp","first_name":"Michael","full_name":"Rapp, Michael"},{"first_name":"Helga","last_name":"Ask","full_name":"Ask, Helga"},{"full_name":"Kjelkenes, Rikka","last_name":"Kjelkenes","first_name":"Rikka"},{"last_name":"Fernandez","first_name":"Sara","full_name":"Fernandez, Sara"},{"full_name":"Van Der Meer, Dennis","first_name":"Dennis","last_name":"Van Der Meer"},{"last_name":"Westlye","first_name":"Lars T.","full_name":"Westlye, Lars T."},{"last_name":"Andreassen","first_name":"Ole A.","full_name":"Andreassen, Ole A."},{"full_name":"Aden, Rieke","last_name":"Aden","first_name":"Rieke"},{"full_name":"Seefried, Beke","first_name":"Beke","last_name":"Seefried"},{"full_name":"Siehl, Sebastian","last_name":"Siehl","first_name":"Sebastian"},{"first_name":"Frauke","last_name":"Nees","full_name":"Nees, Frauke"},{"last_name":"Neidhart","first_name":"Maja","full_name":"Neidhart, Maja"},{"full_name":"Stringaris, Argyris","last_name":"Stringaris","first_name":"Argyris"},{"last_name":"Schwarz","first_name":"Emanuel","full_name":"Schwarz, Emanuel"},{"full_name":"Holz, Nathalie","first_name":"Nathalie","last_name":"Holz"},{"last_name":"Tost","first_name":"Heike","full_name":"Tost, Heike"},{"full_name":"Meyer-Lindenberg, Andreas","first_name":"Andreas","last_name":"Meyer-Lindenberg"},{"last_name":"Christmann","first_name":"Nina","full_name":"Christmann, Nina"},{"first_name":"Karina","last_name":"Jansone","full_name":"Jansone, Karina"},{"last_name":"Banaschewski","first_name":"Tobias","full_name":"Banaschewski, Tobias"},{"full_name":"Banks, Jamie","first_name":"Jamie","last_name":"Banks"},{"full_name":"Schepanski, Kerstin","first_name":"Kerstin","last_name":"Schepanski"},{"full_name":"Schütz, Tatjana","last_name":"Schütz","first_name":"Tatjana"},{"last_name":"Taron","first_name":"Ulrike Helene","full_name":"Taron, Ulrike Helene"},{"full_name":"Eils, Roland","last_name":"Eils","first_name":"Roland"},{"full_name":"Roy, Jean Charles","last_name":"Roy","first_name":"Jean Charles"},{"full_name":"Lett, Tristram A.","last_name":"Lett","first_name":"Tristram A."},{"full_name":"Kebir, Hedi","last_name":"Kebir","first_name":"Hedi"},{"last_name":"Polemiti","first_name":"Elli","full_name":"Polemiti, Elli"},{"last_name":"Hitchen","first_name":"Esther","full_name":"Hitchen, Esther"},{"last_name":"Jentsch","first_name":"Marcel","full_name":"Jentsch, Marcel"},{"full_name":"Serin, Emin","last_name":"Serin","first_name":"Emin"},{"full_name":"Bernas, Antoine","first_name":"Antoine","last_name":"Bernas"},{"last_name":"Vaidya","first_name":"Nilakshi","full_name":"Vaidya, Nilakshi"},{"last_name":"Twardziok","first_name":"Sven","full_name":"Twardziok, Sven"},{"full_name":"Ralser, Markus","first_name":"Markus","last_name":"Ralser"},{"last_name":"Heinz","first_name":"Andreas","full_name":"Heinz, Andreas"},{"first_name":"Henrik","last_name":"Walter","full_name":"Walter, Henrik"}],"abstract":[{"text":"Integrative analyses that incorporate different levels of ‘-omics’ data represent a powerful tool for deciphering the biological mechanisms that underlie environmental influences on mental health and disease. This Comment highlights various aspects of such multi-omics approaches, using the example of the EU-funded environMENTAL project.","lang":"eng"}],"quality_controlled":"1","acknowledgement":"This work was supported by the Horizon 2021 (grant 101057429) and UK Research and Innovation (grants 10038599 and 10041392)-funded project environMENTAL. Other funding included the Medical Research Council and Medical Research Foundation (MR/R00465X/, MRF-058-0004-RG-DESRI, ‘ESTRA’- Neurobiological underpinning of eating disorders: integrative biopsychosocial longitudinal analyses in adolescents; and MR/S020306/1, MRF-058-0009-RG-DESR-C0759 ‘ESTRA’-Establishing causal relationships between biopsychosocial predictors and correlates of eating disorders and their mediation by neural pathways), the EU-funded FP6 Integrated Project IMAGEN (reinforcement-related behavior in normal brain function and psychopathology; LSHM-CT- 2007-037286), the Horizon 2020-funded European Research Council advanced grant for STRATIFY (brain network-based stratification of reinforcement-related disorders; 695313) and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. This paper represents independent research, partly funded by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. The authors thank C. Schmäl for proofreading the manuscript.","_id":"20156","department":[{"_id":"GaNo"}],"page":"1131-1133","article_type":"comment","volume":2,"status":"public","date_updated":"2025-08-11T06:44:03Z","language":[{"iso":"eng"}],"intvolume":"         2","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"10","month":"10","article_processing_charge":"No","doi":"10.1038/s44220-024-00317-y","OA_type":"closed access","date_created":"2025-08-10T22:01:30Z","year":"2024","date_published":"2024-10-01T00:00:00Z","publication":"Nature Mental Health","publication_status":"published","day":"01","citation":{"short":"S. Desrivières, A. Miller, C.M. Mathey, X. Yu, D. Chen, K. Agunbiade, S. Heilmann-Heimbach, A.J. Forstner, G. Schumann, P. Hoffmann, M.M. Nöthen, G. Ogoh, B. Stahl, A.H. Young, N. Clinton, P. Thompson, A. Schwalber, J. Liu, V. Calhoun, X. Chang, Y. Xia, Y. Gong, T. Jia, P. Renner, S. Hese, A. Giner, M. Sanchez, E. Alvarez, B. Spanlang, C. Pearmund, A.P. Athanasiadis, L. Otten, S. Pitel, S. Petkoski, V. Jirsa, K. Schmitt, J. Wilbertz, M. Patraskaki, P. Sommer, I. Claus, A. Pastor, J. Gallego, F.E. Orosa, G.F. Viapiana, M. Slater, L. Marr, G. Novarino, A. Marquand, S.J. Böttger, M. Tschorn, M. Rapp, H. Ask, R. Kjelkenes, S. Fernandez, D. Van Der Meer, L.T. Westlye, O.A. Andreassen, R. Aden, B. Seefried, S. Siehl, F. Nees, M. Neidhart, A. Stringaris, E. Schwarz, N. Holz, H. Tost, A. Meyer-Lindenberg, N. Christmann, K. Jansone, T. Banaschewski, J. Banks, K. Schepanski, T. Schütz, U.H. Taron, R. Eils, J.C. Roy, T.A. Lett, H. Kebir, E. Polemiti, E. Hitchen, M. Jentsch, E. Serin, A. Bernas, N. Vaidya, S. Twardziok, M. Ralser, A. Heinz, H. Walter, Nature Mental Health 2 (2024) 1131–1133.","apa":"Desrivières, S., Miller, A., Mathey, C. M., Yu, X., Chen, D., Agunbiade, K., … Walter, H. (2024). Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. <i>Nature Mental Health</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s44220-024-00317-y\">https://doi.org/10.1038/s44220-024-00317-y</a>","mla":"Desrivières, Sylvane, et al. “Multi-Omics Analyses of the EnvironMENTAL Project Provide Insights into Mental Health and Disease.” <i>Nature Mental Health</i>, vol. 2, no. 10, Springer Nature, 2024, pp. 1131–33, doi:<a href=\"https://doi.org/10.1038/s44220-024-00317-y\">10.1038/s44220-024-00317-y</a>.","ieee":"S. Desrivières <i>et al.</i>, “Multi-omics analyses of the environMENTAL project provide insights into mental health and disease,” <i>Nature Mental Health</i>, vol. 2, no. 10. Springer Nature, pp. 1131–1133, 2024.","ista":"Desrivières S, Miller A, Mathey CM, Yu X, Chen D, Agunbiade K, Heilmann-Heimbach S, Forstner AJ, Schumann G, Hoffmann P, Nöthen MM, Ogoh G, Stahl B, Young AH, Clinton N, Thompson P, Schwalber A, Liu J, Calhoun V, Chang X, Xia Y, Gong Y, Jia T, Renner P, Hese S, Giner A, Sanchez M, Alvarez E, Spanlang B, Pearmund C, Athanasiadis AP, Otten L, Pitel S, Petkoski S, Jirsa V, Schmitt K, Wilbertz J, Patraskaki M, Sommer P, Claus I, Pastor A, Gallego J, Orosa FE, Viapiana GF, Slater M, Marr L, Novarino G, Marquand A, Böttger SJ, Tschorn M, Rapp M, Ask H, Kjelkenes R, Fernandez S, Van Der Meer D, Westlye LT, Andreassen OA, Aden R, Seefried B, Siehl S, Nees F, Neidhart M, Stringaris A, Schwarz E, Holz N, Tost H, Meyer-Lindenberg A, Christmann N, Jansone K, Banaschewski T, Banks J, Schepanski K, Schütz T, Taron UH, Eils R, Roy JC, Lett TA, Kebir H, Polemiti E, Hitchen E, Jentsch M, Serin E, Bernas A, Vaidya N, Twardziok S, Ralser M, Heinz A, Walter H. 2024. Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. Nature Mental Health. 2(10), 1131–1133.","chicago":"Desrivières, Sylvane, Abigail Miller, Carina M. Mathey, Xinyang Yu, Di Chen, Kofoworola Agunbiade, Stefanie Heilmann-Heimbach, et al. “Multi-Omics Analyses of the EnvironMENTAL Project Provide Insights into Mental Health and Disease.” <i>Nature Mental Health</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s44220-024-00317-y\">https://doi.org/10.1038/s44220-024-00317-y</a>.","ama":"Desrivières S, Miller A, Mathey CM, et al. Multi-omics analyses of the environMENTAL project provide insights into mental health and disease. <i>Nature Mental Health</i>. 2024;2(10):1131-1133. doi:<a href=\"https://doi.org/10.1038/s44220-024-00317-y\">10.1038/s44220-024-00317-y</a>"},"publisher":"Springer Nature","publication_identifier":{"eissn":["2731-6076"]},"title":"Multi-omics analyses of the environMENTAL project provide insights into mental health and disease"}